Publications by authors named "Liangjue Cen"
Aims: Our team tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal (mice, rats, and beagles) models with complete spinal cord transection. To further explore the application of SCF for the treatment of paraplegic patients, we developed a new clinical procedure for SCF called vascular pedicle hemisected spinal cord transplantation (vSCT) and tested this procedure in eight paraplegic participants.
Methods: Eight paraplegic participants (American Spinal Injury Association, ASIA: A) were enrolled and treated with vSCT (PEG was applied to the sites of spinal cord transplantation).
Article Synopsis
- The study presents a new surgical method called sural nerve transplantation (SNT) designed to improve conditions for paraplegic patients suffering from spinal cord injuries (SCI) between T1 and T12.
- In a clinical trial involving 12 patients, results showed improvements in autonomic nerve functions and relief from central pain in several participants, along with some recovery of sensory and motor functions.
- While SNT did not fully restore spinal cord continuity, it successfully established some nerve connections and improved certain functions in most patients, suggesting its potential as a treatment option for SCI.