Publications by authors named "Liangjia Qiu"
Article Synopsis
- * High cholesterol levels result in a protein corona that is enriched with apolipoproteins and has fewer complement proteins, leading to stronger inflammatory responses in macrophages and increased uptake in liver cells.
- * The study's in vivo results show that NPs are more effectively targeted to organs like the liver and brain in mice with hypercholesterolemia, highlighting how the metabolome can influence the efficacy and safety of nanomedicines and suggesting a potential for personalized treatment approaches.
How eluents define proteomic fingerprinting of protein corona on nanoparticles.
J Colloid Interface Sci
October 2023
Nanoparticles (NPs) have broad application prospects in the field of biomedicine due to their excellent physicochemical properties. When entering biological fluids, NPs inevitably encountered proteins and were subsequently surrounded by them, forming the termed protein corona (PC). As PC has been evidenced to have critical roles in deciding the biological fates of NPs, how to precisely characterize PC is vital to promote the clinical translation of nanomedicine by understanding and harnessing NPs' behaviors.
View Article and Find Full Text PDFTotal 200 properties related to structural characteristics were employed to represent structures of 400 HA coded proteins of influenza virus as training samples. Some recognition models for HA proteins of avian influenza virus (AIV) were developed using support vector machine (SVM) and linear discriminant analysis (LDA). The results obtained from LDA are as follows: the identification accuracy ( ) for training samples is 99.
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