Case Report: Novel compound heterozygous variants cause achromatopsia in three patients from a family.

This study report a novel missense variant in the gene identified by targeted gene panel sequencing approach in a Chinese family with achromatopsia. The proband, a 24-year-old female, with normal intelligence, motor development and speech abilities exhibited nystagmus, amblyopia, photophobia, and indistinguishable colors. In addition, the two sisters of the proband had the same clinical symptoms, which means that three patients from a family with a monochromasia clinical diagnosis.

Transplantation of acellular amniotic membrane seeded with adipose-derived mesenchymal stem cells in a rat model of intrauterine adhesion.

Objective: This study aimed to investigate the role of acellular amniotic membrane (AAM) loaded with adipose-derived mesenchymal stem cells (ADSCs) for the treatment of intrauterine adhesion.

Methods: One hundred twenty female Spargue-Dawley rats were randomly divided into four groups: sham operation group (the uterus was picked out and incised without treatment), intrauterine adhesion group, the experimental group treated with AAM, and experimental group treated with AAM loaded with ADSCs. Histological and immunohistochemical analysis were performed on 3, 7, and 14 days after surgery to evaluate the degree of uterine fibrosis and regeneration of injured endometrium.

MR Diffusion-Weighted Imaging in Evaluating Immediate HIFU Treatment Response of Uterine Fibroids.

Background: Nowadays, High Intensity Focused Ultrasound (HIFU) is a common surgery option for the treatment of uterine fibroids in China, the immediate response of which is clinically evaluated using Contrast Enhanced (CE) imaging. However, the injection of gadolinium with its potential adverse effect is of concern in CE and therefore, it deserves efforts to find a better imaging method without the need for contrast agent injection for this task.

Objective: To assess the role of diffusion-weighted imaging (DWI) in evaluating the immediate therapeutic response of HIFU treatment for uterine fibroids in comparison with CE.

Silver- and gold-catalyzed intramolecular rearrangement of propargylic alcohols tethered with methylenecyclopropanes: stereoselective synthesis of allenylcyclobutanols and 1-vinyl-3-oxabicyclo[3.2.1]octan-8-one derivatives.

Ag(I)-catalyzed intramolecular reaction of monoarylmethylenecyclopropanes (MCPs) tethered with 1,1,3-triarylprop-2-yn-1-ols provides diastereoselective access to polysubstituted allenylcyclobutanols and the obtained allenylcyclobutanols catalyzed by Au(I) furnish a wide range of bridged bicyclic compounds with a vinyl-substituted quaternary stereogenic center stereoselectively.

Lewis acid catalyzed cascade reactions of 1,6-diynes and 1,6-enynes with vinylidenecyclopropanes.

Lewis acid catalyzed reactions of N-(4-hydroxy-4,4-diarylbut-2-ynyl)-4-methyl-N-prop-2-ynylbenzenesulfonamides or 1,1-diphenyl-4-prop-2-ynyloxybut-2-yn-1-ol (1,6-diynes) 1 and N-allyl-N-(4-hydroxy-4,4-diarylbut-2-ynyl)-4-methylbenzenesulfonamides (1,6-enynes) 2 with vinylidenecyclopropanes 3 selectively produce polycyclic compounds 4, 5 and 10 as well as isopropylidene-3,3-diarylcyclobut-1-enylmethyl derivatives 6 or 7 in good to high yields depending on the substituents on the benzene ring of 3 under mild conditions. An interesting PtCl(2)-catalyzed cyclization of 6 and a Cu(OAc)(2)H(2)O catalyzed Eglinton coupling reaction of 5 and 10 to produce the corresponding 5-isopropylidene-6-methyl-1-(toluene-4-sulfonyl)-7-vinyl-1,2,3,4,5,8-hexahydroazocine derivatives 8 and the coupling products 9 and 11 in good yields have been disclosed, respectively. Plausible mechanisms of these processes have been proposed that belong to a cascade rearrangement followed by the Friedel-Crafts reaction, an intramolecular proton transferring and a cyclization reaction.

Lewis acid catalyzed cascade reactions of diarylvinylidenecyclopropanes and 1,1,3-triarylprop-2-yn-1-ols or their methyl ethers.

The reactions of vinylidenecyclopropanes 1 with 1,1,3-triarylprop-2-yn-1-ols or their methyl ethers 2 in the presence of a Lewis acid selectively produce 4-dihydro-1H-cyclopenta[b]naphthalene derivatives 3 or 1,2,3,8-tetrahydrocyclopenta[a]indene derivatives 4 depending on the substituents on the cyclopropane. Good to high yields are obtained under mild conditions. A plausible cascade Meyer-Schuster rearrangement and Friedel-Crafts reaction mechanism has been proposed.

Lewis acid-catalyzed cascade reactions of arylmethylenecyclopropanes with 1,1,3-triarylprop-2-yn-1-ols or their methyl ethers.

Arylmethylenecyclopropanes 1 can react with 3-methoxy-1,3,3-triarylprop-1-yne 2 or 1,1,3-triarylprop-2-yn-1-ol 2-OH to give the corresponding functionalized methylenecyclobutene, cyclobutane, and cyclopropane derivatives in the presence of Lewis acid BF3.OEt2 under mild conditions. A plausible Meyer-Schuster rearrangement mechanism has been proposed.