Publications by authors named "Liangchen Gui"
The SARS-CoV-2 Omicron variant is characterized by its high transmissibility, which has caused a worldwide epidemiological event. Yet, it turns ominous once the disease progression degenerates into severe pneumonia and sepsis, presenting a horrendous lethality. To elucidate the alveolar immune or inflammatory landscapes of Omicron critical-ill patients, we performed single-cell RNA-sequencing (scRNA-seq) of bronchoalveolar lavage fluid (BALF) from the patients with critical pneumonia caused by Omicron infection, and analyzed the correlation between the clinical severity scores and different immune cell subpopulations.
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- Liver ischemia/reperfusion (I/R) injury often occurs during surgery or trauma and is linked to hepatocyte ferroptosis—an area where the DDX/DHX helicase family may play a role.
- Researchers employed transcriptome analysis to identify expression patterns of DDX/DHX members and used genetic models to investigate the impact of the Dhx58 gene in liver cells during I/R injury.
- The findings indicate that the interferon IFN-α can enhance DHX58 expression, which in turn helps maintain GPX4 levels, a critical protein that protects against ferroptosis in liver cells during I/R injury, suggesting therapeutic potential for IFN-α.