Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases.

Receptor-ligand binding on contacting cells dictates the extent of transmembrane signaling through membrane receptors during cell communication, influencing both the physiological and pathological activities of cells. This process is integral to fundamental biological mechanisms including signal transduction, cancer metastasis, immune responses, and inflammatory cascades, all of which are profoundly influenced by the cell microenvironment. This article provides an overview of the kinetic theory of receptor-ligand binding and examines methods for measuring this interaction, along with their respective advantages and disadvantages.

Activation and modulation of the AGEs-RAGE axis: Implications for inflammatory pathologies and therapeutic interventions - A review.

Chronic inflammation is a common foundation for the development of many non-communicable diseases, particularly diabetes, atherosclerosis, and tumors. The activation of the axis involving Advanced Glycation End products (AGEs) and their receptor RAGE is a key promotive factor in the chronic inflammation process, influencing the pathological progression of these diseases. The accumulation of AGEs in the body results from an increase in glycation reactions and oxidative stress, especially pronounced in individuals with diabetes.

Inhibition of polyphenols on Maillard reaction products and their induction of related diseases: A comprehensive review.

Background: Food products undergo a pronounced Maillard reaction (MR) during the cooking process, leading to the generation of substantial quantities of Maillard reaction products (MRPs). Within this category, advanced glycation end products (AGEs), acrylamide (AA), and heterocyclic amines (HAs) have been implicated as potential risk factors associated with the development of diseases.

Purpose: To explore the effects of polyphenols, a class of bioactive compounds found in plants, on the inhibition of MRPs and related diseases.

Synthesis of Hierarchical ZnFeO@SiO@RGO Core-Shell Microspheres for Enhanced Electromagnetic Wave Absorption.

Hierarchical structured ZnFeO@SiO@RGO core-shell nanocomposites were prepared via a "coating-coating" route, and its structure, composition and electromagnetic properties were characterized. Compared with the binary composites of ZnFeO@SiO, the hierarchical ZnFeO@SiO@RGO ternary composites exhibited enhanced electromagnetic wave (EMW) absorption properties in terms of the effective bandwidth and minimum reflection loss (RL). Furthermore, EMW absorption properties of the prepared samples can be tuned by changing RGO content and thickness of SiO layer to reach the best impedance match.

Cu-doped zinc oxide and its polythiophene composites: preparation and antibacterial properties.

Cu-doped zinc oxide and its polythiophene nanocomposites were prepared by the Sol-Gel and in situ polymerization methods, respectively. The structures, morphologies and compositions of the samples were characterized. The antibacterial properties of the samples on three kinds of strains were determined by using powder inhibition zones, minimum inhibitory concentrations and minimal bactericidal concentrations.

Preparation and antibacterial activities of polyaniline/Cu0.05Zn0.95O nanocomposites.

Polyaniline/Cu(0.05)Zn(0.95)O (PANI/CZO) nanocomposites were prepared by in situ inverse microemulsion method.

One-pot synthesis of biocompatible Te@phenol formaldehyde resin core-shell nanowires with uniform size and unique fluorescent properties by a synergized soft-hard template process.

One-pot hydrothermal process has been developed to synthesize uniform Te@phenol formaldehyde resin core-shell nanowires with unique fluorescent properties. A synergistic soft-hard template mechanism has been proposed to explain the formation of the core-shell nanowires. The Te@phenol formaldehyde resin core-shell nanowires display unique fluorescent properties, which give strong luminescent emission in the blue-violet and green regions with excitation wavelengths of 270 nm and 402 nm, respectively.

Multifunctional polypyrrole/strontium hexaferrite composite microspheres: preparation, characterization, and properties.

Polypyrrole (PPY)/SrFe12O19 composites with tunable electrical and magnetic properties were synthesized by in situ polymerization of pyrrole in the presence of SrFe12O19 particles. The structure of PPY/SrFe12O19 composites was characterized by means of Fourier transform infrared spectroscopy and X-ray diffraction. Transmission electron microscope and scanning electron microscope images illustrated that the spherical composites consisted of SrFe12O19 hexagonal plates sheathed by PPY.

[Synthesis and DNA-binding properties of three compounds containing pyridinecarboxamide].

N, N'-bis(2-pyridinecarboxamide)-1,2-ethane(H2L1), N, N'-bis(2-pyridinecarboxamide)-1, 2-beneze(H2L2) and N-phenylpyridine-2-carboxamide(HL3) were synthesized, and characterized by elemental analysis, IR and HNMR spectra. UV-visible (UV-Vis) spectra, fluorescence spectra and SERS spectra to study the interaction of the three ligands with calf thymus DNA. UV-visible (UV-Vis) spectra show that with the incremental addition of DNA, the bands of H2L1, H2L2 and HL3 all show Hypochromism.

Preparation and magnetic properties of Zn-Cu-Cr-La ferrite and its nanocomposites with polyaniline.

Nanosized Zn(0.6)Cu(0.4)Cr(0.

[Rheological phase synthesis and characterization of lanthanum salicylate and luminescence properties of Tb3+ -doped lanthanum salicylate].

Lanthanum salicylate and Tb3+ -doped lanthanum salicylate were synthesized with the rheological phase reaction method. Elemental analysis, IR, TG, DTA and powder X-ray diffraction were investigated to determine the composition, crystal structure and coordination manner between the COO- and ion La3+ of lanthanum salicylate. The emission and excitation spectra of Tb3+ -doped lanthanum salicylate were also discussed.