Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets with distinct origins and functions. Here, we examined how cancer impacts mononuclear phagocytic APCs in a murine model of breast cancer. Tumors induced the expansion of monocyte-derived tumor-associated macrophages (TAMs) and the activation of type 1 dendritic cells (DC1s), both of which expressed and required the transcription factor interferon regulatory factor-8 (IRF8).
View Article and Find Full Text PDFIn the present study, direct evidence of hydroxyl radical production in livers of Carassius auratus exposed to pentachlorophenol (PCP) was provided using electron paramagnetic resonance (EPR) with spin-trapping. A dose-effect relationship was obtained between hydroxyl radical intensities and PCP exposure. It was observed that hydroxyl radical was significantly induced by 0.
View Article and Find Full Text PDFYing Yong Sheng Tai Xue Bao
January 2007
With electron paramagnetic resonance (EPR) technique, this paper studied the free radicals generation and oxidative stress in Carassius auratus liver after 4, 8, 12, 24 and 72 hours of 2, 4,6-trichlorophenol (2,4,6-TCP) intraperitoneal injection. The results showed that 2,4,6-TCP significantly promoted the generation of free radicals in C. auratus liver.
View Article and Find Full Text PDFIn the present study, electron paramagnetic resonance coupled with spin-trapping technique was used, with alpha-phenyl-N-tert-butylnitrone (PBN) as a spin-trapping agent, to investigate free radical generation in freshwater fish with acute 2,4-dichlorophenol (2,4-DCP) poisoning. The PBN-radical adducts were detected in fish liver samples following treatments of 2,4-DCP (0.025, 0.
View Article and Find Full Text PDFFree radical generation in liver of larval fish (Carassius auratus) after 2,4-dichlorophenol (2,4-DCP) injected intraperitoneally 24 h was studied with electron paramagnetic resonance (EPR) spin trapping technique and alpha-phenyl-N-tert-butylnitrone (PBN) as spin trap reagent. The results show that there is a significant increase of free radical generation in the liver of the fish treated with 2,4-DCP (0.025, 0.
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