Publications by authors named "Liang-feng Fan"
Article Synopsis
- The study discusses a rare case where an intracranial epidermoid cyst transformed into malignant squamous cell carcinoma (SCC) in a 47-year-old woman, leading to severe neurological symptoms like double vision and memory loss.
- Whole exome sequencing was performed on the patient, revealing two significant genetic mutations in the GJB2 and TLR2 genes that may contribute to the development of the SCC.
- The findings highlight the potential importance of these genes in understanding and treating SCC and support whole exome sequencing as a valuable tool for identifying genetic factors in complex diseases.
Contactin associated protein (Caspr), an adhesion molecule, plays roles in formation of paranodal junctions in myelinated axons, neurite outgrowth, synaptic plasticity in nervous system. Here we have shown a novel function of Caspr in pathogenesis of Alzheimer's disease (AD). Caspr distributes around amyloid plaques in APP/PS1 mice.
View Article and Find Full Text PDFBackground: B(x) is a very rare ABO blood group phenotype and the molecular mechanism underlying it still remains largely unknown. This study reports two novel B(x) alleles in two Chinese individuals.
Study Design And Methods: Serologic investigations including serum transferase activity assay were performed with standard methods.