Publications by authors named "Liang-Shi Xiong"
Article Synopsis
- The study aimed to compare the outcomes of radiation-induced hepatic toxicity (RIHT) in patients with hepatocellular carcinoma (HCC) receiving radiotherapy (RT) combined with anti-PD1 antibodies versus RT alone, and to identify factors predicting non-classic radiation-induced liver disease (ncRILD).
- Patients with unresectable HCC were retrospectively analyzed, with 30 receiving RT plus anti-PD1 and 66 receiving RT alone, using propensity score matching to ensure comparability.
- Results indicated similar RIHT rates between the two groups, with a higher frequency of elevated AST levels in the RT + PD1 group after matching; a nomogram was developed based on factors such as tumor number and patient age,
Article Synopsis
- The study focuses on non-classic radiation-induced liver disease (ncRILD) after intensity-modulated radiotherapy (IMRT) in patients with Child-Pugh grade B (CP-B) hepatocellular carcinoma (HCC).
- Among the 75 patients evaluated, 22.7% experienced ncRILD, with specific measurements of liver function and tumor characteristics noted.
- A nomogram was developed to predict the likelihood of ncRILD based on pre-treatment prothrombin time, number of tumors, and average liver dose during treatment, showing strong predictive accuracy.
Article Synopsis
- The study developed a new staging model specifically for assessing hepatocellular carcinoma (HCC) in patients receiving radiotherapy treatments, aiming to improve prognosis classification.
- It involved analyzing a training cohort of 658 patients and a validation cohort of 533 patients, categorizing them into four main stages based on tumor characteristics and overall health.
- Results indicated that the staging model effectively distinguished between patient survival outcomes, with median survival significantly decreasing from stage I (63 months) to stage IV (less than 9 months), suggesting its potential utility for radiation oncologists.
Article Synopsis
- Intensity-modulated radiotherapy (IMRT) is a treatment option for patients with unresectable hepatocellular carcinoma (uHCC), and the study investigates how immune parameters can predict patient survival.
- * The research analyzed clinical data from 309 uHCC patients, finding that higher platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and systemic immune inflammation (SII) after treatment correlated with poorer survival outcomes.
- * A prognostic nomogram was created from the findings, successfully predicting 3- and 5-year survival rates, with validation showing its effectiveness in a separate patient group.
Article Synopsis
- The study investigates the link between radiation pneumonia (RP) and circulating immune cells in patients with esophageal squamous cell carcinoma (ESCC) undergoing chemoradiotherapy (CRT), aiming to create a nomogram model for predicting RP severity.
- It analyzed data from 121 ESCC patients and identified key factors, like TNM stage and CD8+ T cell levels, that predict RP and higher-grade RP using logistic regression.
- The developed nomograms showed good predictive accuracy and will help in identifying high-risk patients for early intervention against ≥ grade 2 RP.
Purpose: Stereotactic body radiotherapy (SBRT) may have significant immunomodulatory effects that enhance tumor response to immune checkpoint inhibitors. This phase 2 clinical trial was conducted to evaluate the safety and efficacy of combining palliative SBRT with camrelizumab (an anti-PD1 monoclonal antibody) in patients with unresectable hepatocellular carcinoma (uHCC).
Methods: Patients with uHCC, Child-Pugh A/B liver function, and at least one measurable lesion were enrolled between April 2020 and August 2022.
Background: Radiation-induced lung injury (RILI) is a severe side effect of radiotherapy for non-small cell lung cancer (NSCLC) ,and one of the major hindrances to improve the efficacy of radiotherapy. Previous studies have confirmed that sodium butyrate (NaB) has potential of anti-radiation toxicity. However, the mechanism of the protective effect of NaB against RILI has not yet been clarified.
View Article and Find Full Text PDFBackground: The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall survival (OS) than sorafenib or TACE monotherapy for patients with hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of radiotherapy (RT) plus monoclonal antibody against programmed cell death 1 (anti-PD1) versus TACE plus sorafenib for patients with advanced HCC.
Methods: Patients with advanced HCC who treated with RT plus anti-PD1 and TACE plus sorafenib were enrolled.
Article Synopsis
- A study examined the role of body composition, particularly subcutaneous adipose tissue index (SATI), as a prognostic factor for hepatocellular carcinoma (HCC) patients undergoing radiotherapy.
- The research involved 109 patients and found that higher SATI was linked to better health outcomes, including progression-free survival (PFS) and overall survival (OS).
- Results indicated that SATI could serve as an independent prognostic factor, suggesting that it may help predict treatment responses for HCC patients, though more studies are needed to confirm this across different populations.
Article Synopsis
- - The study investigates the role of B-cell translocation gene 2 (BTG2) in lung adenocarcinoma (LUAD), revealing that its downregulation is linked to advanced cancer stages and poorer survival rates.
- - Researchers utilized various databases to analyze BTG2 expression, its connection with clinicopathological factors, and its interaction with immune responses in LUAD patients.
- - The findings suggest that BTG2 could serve as a significant immune-related biomarker and potential therapeutic target for improving LUAD patient outcomes.
Article Synopsis
- The study introduced a new method to protect healthy liver tissue during liver regeneration after radiotherapy and aimed to evaluate factors influencing this regeneration.
- Thirty patients were included in a training group and 21 in a validation group, with analyses done to identify key predictors for successful liver regeneration post-treatment.
- The findings indicated that specific liver volume measurements (SVs20) and alanine aminotransferase (ALT) levels were effective predictors of liver regeneration, with the developed model showing strong prediction accuracy.
Article Synopsis
- The study focused on creating and validating a nomogram prediction model to forecast symptomatic radiation pneumonitis (RP) in patients with esophageal cancer.
- Key independent predictors identified include pre-albumin levels, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio, with the nomogram showing a high accuracy (C-index of 0.811).
- The model effectively stratified patients into low, medium, and high-risk groups for developing RP, with incidence rates of 0%, 16.9%, and 57.6% respectively, demonstrating its utility in early risk assessment.
Article Synopsis
- A study investigates the best radiation dosage for treating hepatocellular carcinoma (HCC) using stereotactic body radiation therapy (SBRT), focusing on how different doses affect patient survival and tumor control.
- The research analyzed data from 602 HCC patients treated over six years, categorizing radiation doses into high, moderate, and low levels to assess their impacts on overall survival and disease progression.
- Results showed that higher radiation doses significantly improved patient outcomes, leading the authors to recommend high doses as the primary treatment option if normal tissue can tolerate it.
Article Synopsis
- - The study compared robotic stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT) for treating advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) in 287 patients, using data from 2000 to 2017.
- - After matching 102 patients from both treatment groups, the results showed no significant difference in overall survival, progression-free survival, intrahepatic control, or local control between SBRT and IMRT, suggesting both are equally effective.
- - The research concludes that SBRT, when combined with high-precision tracking technology, is a safe and time-efficient option for treatment, with a recommended biologically effective dose (BED) of
Article Synopsis
- The study aimed to determine if chemoradiotherapy enhances survival in patients with advanced nasopharyngeal carcinoma (NPC) compared to radiotherapy alone.
- Data were analyzed from 496 patients, with those receiving chemoradiotherapy showing better overall survival rates before a matching analysis, but no significant difference in survival rates after adjusting for other factors.
- The final conclusion indicated that both treatment options have comparable overall survival and cancer-specific survival for patients with stage T3-4N0M0 NPC.
Article Synopsis
- Macroscopic vascular invasion (MVI) is a severe progression of hepatocellular carcinoma (HCC) that is difficult to treat, and this study compares two treatment methods: transarterial chemoembolization (TACE) combined with radiotherapy (RT) versus RT alone.
- In a study involving 148 patients with HCC and MVI, those treated with TACE + RT had significantly better overall survival (OS) and progression-free survival (PFS) compared to those who received RT alone, with improvements noted even after adjusting for patient characteristics.
- The TACE + RT group had comparable rates of complications to the RT group, indicating that combining these treatments may provide better long-term outcomes for patients without increasing adverse effects
Follow-up strategy based on event dynamics for stage II nasopharyngeal carcinoma.
Int J Radiat Biol
November 2020
Article Synopsis
- The study explores the follow-up strategies for stage II nasopharyngeal carcinoma (NPC) by analyzing patterns of recurrence and metastasis.
- A retrospective assessment of 251 patients revealed a low recurrence rate (4.0%) and metastasis rate (2.4%), with specific time intervals showing peak hazard rates for both.
- The authors suggest that follow-up strategies should align with current guidelines but be adapted for individual patient needs in the future.
Article Synopsis
- - The study assessed whether adding oxaliplatin to a preoperative chemoradiotherapy (CRT) treatment would enhance survival in patients with locally advanced rectal cancer compared to a regimen with capecitabine alone.
- - Results showed similar rates of pathologic complete response, overall survival, and disease-free survival between the two treatment groups, with no significant survival advantages found for those receiving oxaliplatin.
- - However, the addition of oxaliplatin did lead to a significantly higher incidence of grade 3 toxicity, indicating increased side effects without any survival benefit.
Article Synopsis
- The study aimed to validate the N3 staging classification for nasopharyngeal carcinoma (NPC) as per the 8th edition of the AJCC staging system.
- Researchers analyzed data from 693 NPC patients, divided into groups based on lymph node metastasis level (level IV, N3a, N3b), to compare survival rates over five years.
- Findings showed no significant differences in overall survival and cancer-specific survival rates among the groups, indicating that N stage doesn’t independently predict patient outcomes.
Article Synopsis
- - The study compared the effectiveness of stereotactic body radiation therapy (SBRT) and transarterial chemoembolization (TACE) for treating inoperable early-stage hepatocellular carcinoma (HCC) in 326 patients.
- - Results showed that SBRT had better local control, intrahepatic control, and progression-free survival compared to TACE, while both treatments exhibited similar overall survival rates.
- - The findings suggest that SBRT is a viable alternative to TACE for patients with inoperable BCLC-A stage HCC, indicating a need for further clinical trials to investigate its benefits more thoroughly.
Article Synopsis
- Xerostomia is a common late side effect of radiation therapy, particularly in patients with Nasopharyngeal Carcinoma (NPC), and this study aimed to develop a nomogram to predict its occurrence.
- The research involved 195 NPC patients, analyzing various dose-response factors related to the parotid glands to identify which were most predictive of experiencing grade 2-3 xerostomia one year post-treatment.
- The developed nomogram showed a strong predictive capability with a concordance index of 0.796, outperforming other single measurement methods, indicating its potential to improve treatment outcomes and quality of life for patients.
Article Synopsis
- The study investigates the effectiveness of chemoradiotherapy versus radiotherapy for patients with stage II nasopharyngeal carcinoma (NPC) using data from the SEER database.
- It involved 908 patients, with findings indicating that 5-year overall survival (OS) and cancer-specific survival (CSS) rates were similar for both treatment groups.
- The authors suggest that while chemoradiotherapy did not significantly improve survival compared to radiotherapy, further research is needed to confirm these results due to limitations in the data.
Background: Child-Turcotte-Pugh (CTP) score extensively used to assess hepatic function, predicting postoperative outcome of hepatocellular carcinoma (HCC) patients. Lately, the albumin-bilirubin (ALBI) grade has been identified to be a predictor of overall survival of HCC patients. In this investigation, we compared the pre-SBRT ALBI and CTP scores with the prognosis of patients with HCC.
View Article and Find Full Text PDFArticle Synopsis
- There is currently no agreement on how to predict the prognosis for hepatocellular carcinoma patients receiving radiotherapy, prompting this study to explore the effectiveness of various staging systems.
- The research analyzed 249 patients and calculated overall survival rates, revealing that the 1-, 3-, and 5-year survival rates were 58%, 31%, and 20%, respectively.
- Among the staging systems assessed, the Okuda staging system, the Chinese University Prognostic Index, and the Guangzhou 2001 staging system were found to be the most effective for predicting patient prognosis.
Article Synopsis
- The study aimed to assess how effective three-dimensional conformal radiotherapy (3DCRT) combined with transarterial chemoembolization (TACE) is for treating hepatocellular carcinoma (HCC) that has spread to the portal vein.
- Researchers analyzed data from 182 HCC patients, comparing outcomes among those receiving 3DCRT alone, TACE alone, or both treatments together.
- Results showed that the combination of 3DCRT and TACE led to significantly better overall survival rates compared to using either treatment alone, indicating that this combination approach could be more beneficial for patients with HCC involving portal vein tumor thrombus.