[Relationship between polymorphism of interleukin-8 and silicosis susceptibility].

Objective: To explore the relationship between the polymorphisms of interleukin-8 (IL-8) and the silicosis susceptibility.

Methods: The case group consisted of 101 male patients with stage I silicosis diagnosed by the Pneumoconiosis Diagnosis Expert Panel according to the Chinese National Diagnosis Criteria of Pneumoconiosis (GBZ 70-2009). The control group consisted of 121 workers without silicosis exposed to same dusts.

[Relationship between gene polymorphism of transforming growth factor-beta and pneumoconiosis].

Objective: To explore the association between genetic polymorphisms of TGF-beta (TGF-beta) and susceptibility to pneumoconiosis.

Methods: One hundred and seventeen patients with pneumoconiosis were selected as case. The control group was workers exposed to dust but without pneumoconiosis who had the same sex, nationality, and workshop or work site as case.

[Relationship between genetic polymorphism of interleukin-6 and pneumoconiosis].

Objective: To explore the relationship between interleukin-6 (IL-6) (-634C/G) genetic polymorphisms and the pneumoconiosis.

Methods: A total of 104 male stage I pneumoconiosis patients diagnosed by the Pneumoconiosis Diagnosis Expert Panel according to the Chinese National Diagnosis Criteria of Pneumoconiosis (GBZ 70 - 2002) were selected. The pneumoconiosis comprised 66 silicosis and 38 coal worker' pneumoconiosis (CWP).

[Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury].

Objective: To explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.

Methods: In 1:1 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.