Publications by authors named "Liang-Peng Li"
Stimulation of adult cardiomyocyte proliferation is a promising strategy for treating myocardial infarction (MI). Earlier studies have shown increased CCL2 levels in plasma and cardiac tissue both in MI patients and mouse models. In present study we investigated the role of CCL2 in cardiac regeneration and the underlying mechanisms.
View Article and Find Full Text PDFHeart failure with preserved ejection fraction (HFpEF) is highly prevalent, and lacks effective treatment. The aberration of WNT pathway underlies many pathological processes including cardiac fibrosis and hypertrophy, while porcupine is an acyltransferase essential for the secretion of WNT ligands. In this study we investigated the role of WNT signaling pathway in HFpEF as well as whether blocking WNT signaling by a novel porcupine inhibitor CGX1321 alleviated HFpEF.
View Article and Find Full Text PDFArticle Synopsis
- Cardiac hypertrophy, often caused by stressors like angiotensin II (Ang II), can lead to heart failure; this study investigates how miR-133a-3p affects pyroptosis in this context.
- Using various assays, the researchers found that Ang II induces hypertrophy and pyroptosis in heart cells, while miR-133a-3p expression decreases, offering protective effects when overexpressed.
- MiR-133a-3p targets IKKε, inhibiting its expression and thereby reducing pyroptosis and hypertrophy, suggesting that increasing miR-133a-3p could be a potential treatment for cardiac hypertrophy.
Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis.
Acta Pharmacol Sin
October 2019
Irisin, a myokine, is cleaved from the extracellular portion of fibronectin domain-containing 5 protein in skeletal muscle and myocardium and secreted into circulation as a hormone during exercise. Irisin has been found to exert protective effects against lung and heart injuries. However, whether irisin influences myocardial infarction (MI) remains unclear.
View Article and Find Full Text PDFRemote ischemic conditioning for the prevention of contrast-induced acute kidney injury in patients undergoing intravascular contrast administration: a meta-analysis and trial sequential analysis of 16 randomized controlled trials.
Oncotarget
October 2017
Article Synopsis
- A meta-analysis was conducted to assess the effectiveness of remote ischemic conditioning (RIC) in preventing contrast-induced acute kidney injury (CI-AKI) in patients receiving intravascular contrast.
- The study analyzed 16 randomized controlled trials involving 2,175 patients and found that RIC significantly reduced the incidence of CI-AKI and major adverse cardiovascular events.
- Both types of RIC, known as remote ischemic preconditioning (RIPrC) and remote ischemic postconditioning (RIPoC), were effective, and perioperative hydration may enhance RIC's benefits.
Background: Transforming growth factor-beta 1(TGF-β1) is involved in the development of acute rejection (AR) episodes in solid organ transplant recipients; and a number of studies have been conducted to investigate the combined effects of human TGF-β1 gene (TGFB1) +869 T/C and +915 G/C polymorphisms on AR risk. However, the results obtained are inconclusive.
Methods: Eligible studies that investigated the haplotypic association between TGFB1 +869 T/C and +915 G/C polymorphisms and AR risk were comprehensively searched in the PUBMED, EMBASE, China National Knowledge Infrastructure, and Wanfang Database.
Background: Transforming growth factor beta-1(TGFB1) is involved in the acute rejection (AR) episodes of solid organ transplant recipients. However, results from published studies on the association between donor/recipient TGFB1 +869T/C polymorphism and AR risk are conflicting and inconclusive.
Methods: PUBMED, EMBASE, CNKI and Wanfang Database were searched to identify eligible studies investigating the association between donor/recipient TGFB1 +869T/C polymorphism and AR risk.
Objective: To evaluate the quality of the radial artery for coronary artery bypass grafting (CABG) from patients with diabetes by observing the morphology of the radial artery and detecting the expression of vascular endothelial growth factor (VEGF) which may attribute to the long-term patency rate of the coronary artery bypass grafting.
Methods: Samples from 20 cases of diabetic and non-diabetic patients were prospective collected from June 2009 to December 2010. HE staining technique was used to test the morphology of radial artery through the observation of 20 cases of diabetic and 20 cases of non-diabetic patients who undergone CABG.