Publications by authors named "Liang-Ming Yen"
Article Synopsis
- The study investigates the relationship between gene variations in SDF-1 and CXCR4 and their role in increasing the risk of oral and pharyngeal squamous cell carcinoma (OPSCC) due to chronic inflammation from betel quid, cigarettes, and alcohol.
- In a sample of 452 OPSCC patients and 424 healthy controls, significant associations were found between certain CXCR4 gene variants (C allele and C/C genotype) and increased OPSCC risk.
- The results suggest that the presence of these gene variations, particularly in individuals with risk habits like BQ chewing, tobacco smoking, and alcohol consumption, can serve as markers for susceptibility to OPSCC.
Background: Type V collagen (COL5), in the functional heterotrimer [α1(V) α2(V)] isoform, participates in the malignancies of various cancers. However, its role in tongue squamous cell carcinoma (TSCC) remains unclear.
Materials And Methods: The expression levels of COL5A1 and COL5A2 polypeptide chains were examined using the tissue microarray from 245 TSCC patients with immunohistochemistry.
We aimed to investigate the association of the expression levels of five epithelial-mesenchymal transition (EMT)-related proteins (Snail, Twist, E-cadherin, N-cadherin, and Vimentin) with tumorigenesis, pathologic parameters and prognosis in tongue squamous cell carcinoma (TSCC) patients by immunohistochemistry of tissue microarray. The expression levels of Snail, E-cadherin, N-cadherin and Vimentin were significantly different between the tumor adjacent normal and tumor tissues. In tumor tissues, lower E-cadherin and higher N-cadherin levels were associated with a higher grade of cell differentiation, advanced stage of disease, and lymph node metastasis.
View Article and Find Full Text PDFObjective: Interleukin (IL)-4 is a key cytokine in humoral and adaptive immunity. This study aimed to evaluate the association of IL-4 genetic variants (-590C>T and VNTR in intron 3) with the risk and prognosis of oral and pharyngeal squamous cell carcinoma (OPSCC).
Design: A total of 1215 subjects, which included 623 healthy controls and 592 OPSCC cases (463 oral squamous cell carcinoma (OSCC) and 129 pharyngeal squamous cell carcinoma (PSCC) cases), were recruited.