Publications by authors named "Liang-Huey Chang"
Comparison of escitalopram and paroxetine in the treatment of major depressive disorder.
Int Clin Psychopharmacol
November 2013
Article Synopsis
- This study compared the effectiveness and tolerability of the antidepressants escitalopram and paroxetine in treating major depressive disorder among 399 patients.
- Results showed that escitalopram led to significantly greater reductions in depression symptoms at weeks 6 and 8 compared to paroxetine, although both medications had similar remission rates.
- Escitalopram also caused fewer mild side effects, such as nausea and drowsiness, highlighting its potential advantage, but the study suggests further research with a placebo and double-blind design is needed for more conclusive findings.
Aim: The liver CYP1A2 enzyme may metabolize antidepressant escitalopram (S-CIT) to S-desmethylcitalopram (S-DCIT) and S-didesmethylcitalopram (S-DDCIT). This study tested whether genetic polymorphisms in the CYP1A2 gene are associated with the treatment responses to S-CIT.
Materials & Methods: Ten SNPs in CYP1A2 were selected and genotyped in 158 patients under S-CIT treatment.
Article Synopsis
- The ABCB1 protein is crucial for regulating drug transport in the intestine and blood-brain barrier, potentially impacting how well antidepressants work.
- A study analyzed genetic variants (polymorphisms) in the ABCB1 gene in 100 MDD patients receiving escitalopram (S-CIT) treatment over 8 weeks.
- Significant genetic associations were found with depression severity and treatment response, indicating that certain genetic markers may help predict how individuals respond to S-CIT.