Effects of orientation and distance of goats on blast lung injury characteristics on a plateau above 4500-meter.

Purpose: High explosives are used to produce blast waves to study their biological effects. The lungs are considered as the critical target organ in blast-effect studies. The degree of lung hemorrhaging is related to both the explosive power and the increased lung weight.

Pulmonary microvascular dysfunction and pathological changes induced by blast injury in a rabbit model.

Background: Vascular leakage has been proven to play a critical role in the incidence and development of explosive pulmonary barotrauma. Quantitatively investigated in the present study was the severity of vascular leakage in a gradient blast injury series, as well as ultrastructural evidence relating to pulmonary vascular leakage.

Methods: One hundred adult male New Zealand white rabbits were randomly divided into 5 groups according to distance from the detonator (10 cm, 15 cm, 20 cm, 30 cm, and sham control).

The effects of intra-abdominal hypertension on the secretory function of canine adrenal glands.

Intra-abdominal hypertension (IAH) can damage multiple organ systems, but the explicit impact on the adrenal gland is unclear. To evaluate the effects of intra-abdominal pressure (IAP) on the secretory function of the adrenal glands, we established canine models of IAH. By comparing morphology; hemodynamics; plasma cortisol, aldosterone, epinephrine, and norepinephrine concentrations; and the expression of IL-1, IL-6, and TNF-α in adrenal gland tissue from these dogs, we found that hemodynamic instability occurred after IAH and that IAH increased the plasma cortisol, aldosterone, epinephrine, and norepinephrine concentrations.

Treatment of rabbit femoral defect by firearm with BMP-4 gene combined with TGF-beta1.

Background: Firearm bone fractures are difficult to treat compared with general ones as both soft tissue and bone are injured more extensively and severely with contamination in the wound track. The bone morphogenetic protein (BMP) and transforming growth factor (TGF)-beta play an important role in bone fracture healing. Therefore, BMP-4 combined with TGF-beta1 was used to improve and accelerate the repair of rabbit femoral defect resulting from firearm.

Cell death-inducing DFF45-like effector may take part in neuronal apoptosis of the lumbar spinal cord after sciatic nerve injury caused by a firearm.

Objective: To investigate neuronal apoptosis and gene regulation after peripheral nerve injury caused by a firearm.

Methods: A rabbit model of sciatic nerve injury caused by a firearm was used. Neuronal apoptosis was determined by using terminal transferase-mediated dUTP nick end-labeling and flow cytometry.

Surgical treatment for rabbits' femoral arteries subjected to gunshot wounds combining with seawater immersion.

Objective: To investigate the surgical treatment methods and evaluate the outcome of gunshot wounds combining with seawater immersion in rabbits' femoral arteries.

Methods: One hundred healthy New Zealand white rabbits (either sex, 3.14 kg+/-0.

Pathological study of rabbits' femoral arteries subjected to gunshot wounds combining with seawater immersion.

Objective: To investigate pathological characteristics of gunshot wounds concomitant seawater immersion in rabbits' femoral arteries.

Methods: Thirty rabbits were divided randomly into 3 groups: simple gunshot-wound group (Group I, n = 10), gunshot wound with seawater immersion for 30 mins (Group II, n = 10), and 60 mins group (Group III, n = 10). Femoral arteries were impacted by 0.

Identification of differentially expressed genes from spinal cord after firearm injury to rabbit sciatic nerves.

Objective: Peripheral nerve regeneration depends on gene regulation by central neurons. To search for more effective treatment methods to improve the regeneration of wounded peripheral nerves, gene expression profile of spinal cord after firearm injury to rabbit sciatic nerves are studied with DNA micro-array technique.

Methods: A total of 54 rabbits were randomly divided into 4 groups: Groups d1, d3, d7 and normal control group.