Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic disease. Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial. Based on a thorough literature review, we design a surgical algorithm for ZES and list some significant consensus findings and recommendations: (1) For sporadic ZES, surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging findings.
View Article and Find Full Text PDFClin Transl Gastroenterol
September 2018
Background: Previous study, using immunoblotting with IgG and membrane proteins, identified prohibitin (PHB) as a potential immunogenic membrane antigen. Now, investigate PHB expression and biological functions in pancreatic cancer.
Methods: PHB expression was analysed in PDAC cell lines, normal pancreas tissues, cancer tissues, PDAC patient sera and healthy volunteer sera using QRT-PCR, Western blotting, IHC, and ELISA, and a survival analysis and a COX regression analysis were performed.
Background: Intra-Body Communication (IBC), which utilizes the human body as the transmission medium to transmit signal, is a potential communication technique for the physiological data transfer among the sensors of remote healthcare monitoring system, in which the doctors are permitted to remotely access the healthcare data without interrupt to the patients' daily activities.
Methods: This work investigates the effects of human limb gestures including various joint angles, hand gripping force and loading on galvanic coupling IBC channel. The experiment results show that channel gain is significantly influenced by the joint angle (i.