Publications by authors named "Liang Zheng"

Direct recycling technology can effectively solve the environmental pollution and resource waste problems caused by spent lithium-ion batteries. However, the repaired LiNiCoMnO (NCM) black mass by direct recycling technology shows an unsatisfactory cycle life, which is attributed to the formation of spinel/rock salt phases and rotational stacking faults caused by the in-plane and out-of-plane migration of transition metal (TM) atoms during charge/discharge. Herein, local lattice stress is introduced into the regenerated cathode during repair.

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Flexible perovskite solar cells (FPSCs) have great promise for applications in wearable technology and space photovoltaics. However, the unpredictable crystallization of perovskite on flexible substrates results in significantly lower efficiency and mechanical durability than industry standards. A strategy is investigated employing the polymer electrolyte poly(allylamine hydrochloride) (PAH) to regulate crystallization and passivate defect states in perovskite films on flexible substrates.

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Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disorder worldwide, with an increasing incidence in recent years. While previous studies have suggested an association between the air pollutant PM2.5 and NAFLD, there is still considerable debate regarding the existence of a clear causal relationship between air pollution and NAFLD.

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Background/aims: Growing recognition identifies sessile serrated lesions (SSL) as colorectal cancer (CRC) precursors. However, the SSL detection rate remains debatable and lacks a definitive consensus. Additionally, understanding the influencing factors in SSL development is limited.

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Mechanical fatigue of the binders during the repeated volume change of Si-based anodes induces binder network collapse, resulting in lithium-ion batteries (LIBs) failing prematurely. Herein, we designed a damageless polymer binder with a mechanically interlocked network utilizing [n]daisy chains (MIN) and poly(acrylic acid) (PAA) to improve the structural cohesion of the Si-based anode. This MIN@PAA binder exhibits robust mechanical properties, high elasticity, and excellent adhesion.

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Despite competitive compatibility with high-nickel cathodes, chloride solid electrolytes (SEs) still experience inevitable side reactions at the cathode/SE interface, causing capacity decay in all-solid-state lithium batteries (ASSLBs) during cycling. Herein, a three-electrode ASSLB testing device is developed to comprehensively reveal the interface failure mechanisms of the ultrahigh-nickel LiNiCoMnO (NCM92) cathode paired with LaCl-based chloride SE LiLaZrTaCl (LLZTC). Distribution of relaxation time (DRT) analysis clearly shows the ASSLB degradation accompanied by a significant NCM92/LLZTC interface impedance increase, which becomes more pronounced at the higher cutoff charging voltage of 4.

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Rapid and accurate state of health (SOH) estimation of retired batteries is a crucial pretreatment for reuse and recycling. However, data-driven methods require exhaustive data curation under random SOH and state of charge (SOC) retirement conditions. Here, we show that the generative learning-assisted SOH estimation is promising in alleviating data scarcity and heterogeneity challenges, validated through a pulse injection dataset of 2700 retired lithium-ion battery samples, covering 3 cathode material types, 3 physical formats, 4 capacity designs, and 4 historical usages with 10 SOC levels.

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Article Synopsis
  • The study investigates the role of Apolipoprotein O (APOO) in breast cancer (BRCA), finding that higher APOO levels correlate with worse patient outcomes, suggesting its potential as a diagnostic marker.
  • Methods involved analyzing gene expression and conducting assays to understand APOO's functions; results showed that reducing APOO levels hindered cancer cell growth and movement, highlighting its involvement in key signaling pathways.
  • The conclusions suggest that targeting APOO could lead to new treatment strategies for BRCA by modulating apoptosis and autophagy pathways.
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Historical cultural heritage sites are valuable for all of mankind, as they reflect the material and spiritual wealth of by nations, countries, or specific groups during the development of human civilization. The types and functions of microorganisms that form biofilms on the surfaces of architectural heritage sites influence measures to preserve and protect these sites. These microorganisms contribute to the biocorrosion of architectural heritage structures through the cycling of chemical elements.

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Enzymatic cascade reactions with high activity and specificity in living cells always benefit from multicompartmentalized organelles that provide separately confined spaces for enzymes, avoiding their mutual interference to ensure the high-efficiency operation of necessary vital movements. Inspired by this, we designed a 3D spherical microreactor (Au@H-APF@Pt) with biomimetic cascade catalysis for glucose detection. First, ultrasmall gold nanoparticles were immobilized in situ on the internal cavities of hollow 3-aminophenol formaldehyde resin (H-APF) nanospheres, along with glucose oxidase activity.

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Background: SHR4640, a highly selective URAT1 inhibitor, was evaluated to investigate its inhibitory effects on CYP2C8 and CYP3A4 in vivo clinical trial. This study assessed the pharmacokinetic (PK) impact of SHR4640 when co-administered with the CYP2C8 probe substrate repaglinide and the CYP3A4 probe substrate midazolam.

Research Design And Methods: In this single-center, randomized, double-blind, placebo-controlled study, participants were randomly allocated in a 1:1:1 ratio to SHR4640 Group A, SHR4640 Group B, and placebo group and received oral repaglinide, midazolam, SHR4640 or placebo at specific times.

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Patients with heart failure (HF) often experience iron deficiency. Intravenous iron supplementation has been widely used in clinical practice to facilitate the treatment of HF. However, the association between dietary iron intake and HF still needs to be elucidated.

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Prenatal ethanol exposure can cause a broad range of abnormalities in newborns known as Fetal Alcohol Spectrum Disorder (FASD). Despite significant progress in understanding the disease mechanisms of FASD, there remains a strong global need for effective therapies. To evaluate the therapeutic potential of sulforaphane (SFN), an active compound extracted from cruciferous vegetables, in preventing FASD, ethanol-exposed zebrafish embryos were pretreated, co-treated, or post-treated with various concentrations of SFN.

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The floor plan layout of museum exhibition spaces is the skeleton network of the museum, which determines the internal circulation and spatial form of the museum. This paper studies the method and practice of using artificial intelligence technology to assist in the space design of exhibition halls in urban cultural museums. First, it introduces the limitations of traditional space design methods for exhibition halls in urban cultural museums and the superiority and application prospects of the CGAN (conditional generative adversarial network) model in space design.

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Nonalcoholic steatohepatitis (NASH) is the advanced stage of nonalcoholic fatty liver disease (NAFLD), which is distinguished by the accumulation of fat in the liver, damage to liver cells, and inflammation. Chaihu Shugan powder (CSP), a renowned traditional Chinese medicine (TCM) blend extensively utilized in China to address liver disease, has demonstrated its efficacy in reducing lipid buildup and effectively combating inflammation. Hence, the primary objective of this research is to examine the impacts and possible mechanisms of CSP on NASH through assessments of liver histopathology, lipidomic analysis, and gene expression.

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In the field of numerical control machining, tool alignment technology is a key link to ensure machining accuracy and quality. Tool alignment refers to determining the correct position of the tool relative to the workpiece, and its accuracy directly affects the precision of part machining. With the development of precision machining technology, the research and application of cutting technology are increasingly valued.

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Nonalcoholic steatohepatitis (NASH) is a form of chronic liver disease that is characterized by liver inflammation and steatosis, with possible progression to fibrosis. Currently, no drugs have been approved for the treatment of NASH. In this study, we isolated a polysaccharide from rhizome (AP) and established a methionine- and choline-deficient (MCD) diet -induced NASH mouse model to investigate the preventive effect and potential mechanism of AP on NASH.

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Article Synopsis
  • This study investigates how exposure to methylglyoxal (MGO) affects the molecular and biochemical properties of SH-SY5Y human neuroblastoma cells using advanced proteomics and metabolomics techniques.
  • Results show that MGO significantly disrupts cellular functions such as protein synthesis, mitochondrial function, and oxidative stress responses, indicating its neurotoxic effects.
  • Additionally, while MGO exposure causes cellular toxicity and stress, the cells also demonstrate adaptive mechanisms, such as increasing protein synthesis and activating protective pathways, highlighting potential biomarkers for MGO exposure and targets for therapy.
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The detection of gravitational waves has ushered in a new era of observing the universe. Quantum resource advantages offer significant enhancements to the sensitivity of gravitational wave observatories. While squeezed states for ground-based gravitational wave detection have received marked attention, the generation of squeezed states suitable for mid-to-low-frequency detection has remained unexplored.

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Article Synopsis
  • Hippo signaling plays a key role in regulating tissue health and organ size by controlling the activity of YAP1, which is closely associated with transcription factors known as TEADs.
  • Researchers found that the drug chlorpromazine (CPZ) can inhibit YAP1 in nasopharyngeal carcinoma (NPC) cells by interacting with another protein, FOXP3, leading to reduced cell growth and migration.
  • Further analysis suggests that FOXP3 competes with TEAD4 to regulate YAP1's activity, indicating its potential as a prognostic marker in head and neck squamous cell carcinoma (HNSCC).
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Article Synopsis
  • Leonurine, a compound derived from the Lamiaceae plant, shows potential benefits in treating nonalcoholic fatty liver disease (NAFLD) due to its anti-oxidative, anti-apoptotic, and metabolic regulation properties, though its exact mechanisms are not fully understood.
  • In a study involving mice, different groups were treated with leonurine and other treatments to observe changes in liver health after a high-fat high-sugar diet, revealing that leonurine positively influenced lipid metabolism-related genes.
  • Further analysis indicated that leonurine may lower lipid levels by activating the AMPK signaling pathway and affecting lipid molecules, specifically through the ADRA1a/AMPK/SCD1 axis, thus improving liver lipid
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Background: The association of body mass index (BMI) with survival outcomes in patients with advanced non-small cell lung cancer (NSCLC) treated with first-line chemotherapy, immunotherapy, or chemoimmunotherapy is controversial. We aimed to investigate these associations, including associations in male and female patients specifically, in a multicenter cohort study.

Methods: We retrospectively analyzed data from seven cohorts comprising 7021 advanced non-small cell lung cancer patients who received chemotherapy (three cohorts), immunotherapy (two cohorts), and chemoimmunotherapy (two cohorts) from five data sources, including a de-identified nationwide (US-based) NSCLC clinico-genomic database and two randomized, double-blind, phase 3 clinical trials.

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Objective: To compare the effects of unilateral thoracic paravertebal block with lidocaine on hemodynamic and the level of consciousness during double lumen endotracheal intubation.

Methods: From June to october 2021, a total of 40 patients American Society of Anesthesiologists (ASA) physical status Ⅰ-Ⅱ, aged 19-65 years, scheduled for elective thoracic sugeries in Peking University International Hospital block with under general anesthesia requiring orotracheal intubation were recruited and divided into two groups: The double-lumen endobronchial intubation (group C) and double-lumen endobronchial intubation after thoracic paravertebal block with lidocaine (group P). After an intravenous anesthetic induction, the orotracheal double-lumen intubation was performed using a Macintosh direct laryngoscopy, respectively.

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