Publications by authors named "Liang Ye"

In order to study the effect of the simplified formula of Jinfukang Oral Liquid(ALG-12) on renal tubular injury induced by cisplatin(DDP), 48 C57 mice were divided into control group, model group, DDP group, and DDP combined with low, medium, and high dose groups of ALG-12. The mice were administered for 16 days after the establishment of the subcutaneous Lewis lung cancer heterotopic transplant tumor model of mice. The pathological changes, serum creatinine(Scr), blood urea nitrogen(BUN), kidney injury molecule 1(Kim-1), neutrophil gelatinase-associated lipocalin(NGAL), malondialdehyde(MDA), and total superoxide dismutase(T-SOD) in renal tissue and the degree of renal tubular cell apoptosis were analyzed to investigate the effect of ALG-12 on renal injury induced by DDP treatment on non-small cell lung cancer(NSCLC).

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The integration of multiple therapeutic agents within a single nano-drug carrier holds promise for advancing anti-tumor therapies, despite challenges posed by their diverse physicochemical properties. This study introduces a novel multi-stage microfluidic co-encapsulation platform designed to address these challenges. By carefully orchestrating the nano-precipitation process sequence, this platform achieves sequential encapsulation of two drugs with markedly different physicochemical characteristics.

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Objectives: The choice of surgical access for resection and reconstruction of buccal squamous cell carcinoma (BSCC) with the lip-splitting incision is controversial. Thus, this study aimed to evaluate the clinical and functional outcomes of midline lip split with lazy-S incision (MLSI) against the lateral lip-splitting incision (LLSI).

Methods: A retrospective review was conducted on 41 patients with primary BSCC who underwent resection and reconstruction using MLSI approach (n = 19) and LLSI approach (n = 22) between 2022 and 2024.

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Background: This study aimed to characterize the relationship between habitual food intake and OSA.

Methods: The diet of 200 volunteers was evaluated using a Food Frequency Questionnaire. The patients were further allocated to mild, moderate, and severe OSA groups.

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Tumoral immune escape is an obstacle to successful cancer therapy. Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO1) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance, and IDO1 inhibition is an active area of drug development. Several classes of small molecule-based IDO1 inhibitors have already been reported.

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Targeted at organic dye pollutants, a stable HOF was combined with an alginate (SA) hydrogel to enhance the affinity for cationic dyes. The as-obtained HOF@SA membrane (weight ratio: 1/1) shows a high adsorption capacity (729.21 mg g), adsorption selectivity and good recycling performance towards methylene blue.

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Background: Dental pulp stem cells (DPSCs) have acquired noteworthy attention for their application in treating ischemic diseases and facilitating tissue regeneration. However, the host's immune response following allogenic DPSC transplantation often handicaps the long-term survival of transplanted cells, thereby limiting the application of DPSCs in cell therapy. This study aims to investigate whether genetic modification can alleviate the immunogenicity of DPSCs.

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Fungal infections present a significant health risk, particularly in immunocompromised individuals. Berberine, a natural isoquinoline alkaloid, has demonstrated broad-spectrum antimicrobial activity, though its antifungal potential and underlying mechanisms against both yeast-like and filamentous fungi are not fully understood. This study investigates the antifungal efficacy of berberine against , , , and in vitro, as well as its therapeutic potential in a murine model of cryptococcal infection.

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It has been proven that robot-assisted rehabilitation training can effectively promote the recovery of upper-limb motor function in post-stroke patients. Increasing patients' active participation by providing assist-as-needed (AAN) control strategies is key to the effectiveness of robot-assisted rehabilitation training. In this paper, a greedy assist-as-needed (GAAN) controller based on radial basis function (RBF) network combined with 3 degrees of freedom (3-DOF) potential constraints was proposed to provide AAN interactive forces of an end-effect upper limb rehabilitation robot.

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Article Synopsis
  • * Researchers found that using a glutamine antagonist called DON reduced bladder cancer cell growth and inhibited tumor growth in mice with a modified drug (JHU083) to reduce side effects.
  • * However, prolonged treatment altered T-cell immune response, increasing PD-L1 expression in cancer cells; combining JHU083 with gefitinib helped counteract this and improved treatment effectiveness.
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Yessotoxin (YTX) is a disulfated toxin produced by harmful dinoflagellates and causes risks to aquatic animals. Polystyrene (PS) microplastics could absorb toxins in seawaters but pose threats to organism growth. In this study, the combined toxic effects of YTX (0, 20, 50, and 100 µg L) and PS (0, 5, and 10 µg mL) on the survival, reproduction, and population growth of marine rotifer Brachionus plicatilis at 20 °C, 25 °C, and 30 °C were evaluated.

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Liver kinase B1 (LKB1) is a serine/threonine kinase controlling cell homeostasis. Among post-translational modification, Sumoylation is vital for LKB1 activating adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), the key regulator in energy metabolism. Of note, AMPK-regulated fatty acid metabolism is highly involved in maintaining normal renal function.

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Compared with monometallic metal-organic frameworks (MOFs), the synergistic effect of multiple metals significantly enhances the catalytic performance of the CO cycloesterification reaction, leading to improved CO adsorption and catalytic conversion capabilities. To investigate this concept, a high-entropy MOF-74 (HE-MOF-74) with a uniform distribution of five distinct metal ions (Zn, Mg, Ni, Co, and Cu) was successfully synthesized using a straightforward mechanical ball milling technique and comprehensively characterized (including structural, morphological, and physicochemical properties). The results reveal that HE-MOF-74 exhibits significantly increased specific surface area and CO adsorption capacity compared with those of monometallic MOF-74.

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Article Synopsis
  • * This study identified a trap energy level of 0.08 eV, suggesting that interface traps are primarily responsible for the current collapse during semi-on-state stress.
  • * Multi-frequency capacitance-voltage (C-V) testing indicated that the density of these interface traps ranges from 1.37×10^13 to 6.07×10^12 cm^-2 eV^-1, with energy levels between 0.29 eV and 0.45 eV.
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Objective: The study aims to identify distinct population-specific comorbidity progression patterns, timely detect potential comorbidities, and gain better understanding of the progression of comorbid conditions among patients.

Methods: This work presents a comorbidity progression analysis framework that utilizes temporal comorbidity networks (TCN) for patient stratification and comorbidity prediction. We propose a TCN construction approach that utilizes longitudinal, temporal diagnosis data of patients to construct their TCN.

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  • Potassium (K) is crucial for maize growth, and arbuscular mycorrhizal fungi (AMF) enhance K uptake, highlighting the need to understand the molecular mechanisms involved.
  • The study conducted RNA sequencing and gene analysis on maize with and without AMF inoculation under varied K conditions, revealing that AM symbiosis improves K concentration and plant weight, particularly under low-K stress.
  • Key findings identified 21 hub genes and 14 gene families related to K uptake, with many genes being upregulated in AMF-colonized roots in low K conditions, signifying the role of AMF in helping maize adapt to K-deficiency stress.
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Tissue engineering offers a promising alternative for oral and maxillofacial tissue defect rehabilitation; however, cells within a sizeable engineered tissue construct after transplantation inevitably face prolonged and severe hypoxic conditions, which may compromise the survivability of the transplanted cells and arouse the concern of anaerobic infection. Microalgae, which can convert carbon dioxide and water into oxygen and glucose through photosynthesis, have been studied as a source of oxygen supply for several biomedical applications, but their promise in orofacial tissue regeneration remains unexplored. Here, we demonstrated that through photosynthetic oxygenation, () supported dental pulp stem cell (DPSC) energy production and survival under hypoxia.

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  • Energy metabolism disorder can make us age faster because it stops our body from breaking down fats and starts storing too much of it.
  • Omega-3 fatty acids, especially EPA, can help keep our energy levels up and our organs healthy, which slows down aging.
  • This study shows that adding Omega-3s to our diets could be a good way to help older people age more healthily.
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Objectives: Mechanical debridement supplemented with antibacterial agents effectively eradicates subgingival biofilms formed in the periodontal pockets of severe periodontitis patients. However, the available antimicrobial agents have limited penetrating ability to kill the bacteria encased in the deep layers of biofilms. This study aimed to fabricate a novel magnetic nanoparticle (MNP) loaded with rhamnolipid (RL) and vancomycin (Vanc, Vanc/RL-Ag@FeO) to combat subgingival biofilms.

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Aims: Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage is a main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role in FAO dysregulation in tubular cells is not clarified.

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Background: Primary Carnitine Deficiency (PCD) is a potentially life-threatening autosomal recessive monogenic disorder arising from mutations in the organic cation transporter 2 (OCTN2) gene. Dilated cardiomyopathy (DCM) is a prevalent symptom associated with this condition, and episodes of metabolic disturbance may lead to sudden death. However, the pathogenic mechanism remains unclear.

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Left-behind children, as a large-scale disadvantaged group, encounter an array of risk factors that impede their academic development because of parental migration. The current study aimed at investigating the roles of left-behind cumulative risk and growth mindset on academic adjustment and exploring whether growth mindset moderated the association between left-behind cumulative risk and academic adjustment in left-behind middle school students. A total of 1184 left-behind middle school students (615 males; 12-16 years) participated in the study.

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Obtaining high-quality data sets from raw data is a key step before data exploration and analysis. Nowadays, in the medical domain, a large amount of data is in need of quality improvement before being used to analyze the health condition of patients. There have been many researches in data extraction, data cleaning and data imputation, respectively.

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