A β-cyclodextrin-based supramolecular photonic crystal hydrogel biosensor with macroporous structures for naked-eye visual detection of cholesterol.

Cholesterol (CHO) is an essential lipid in cell membranes and a precursor for vital living substances. Abnormal CHO levels can cause cardiovascular diseases. Therefore, simple and accurate monitoring of CHO levels is crucial for early diagnosis and effective management of cardiovascular diseases.

Evaluation of Pregnancy Risks in Women with Subchorionic Hematoma Using Machine Learning Models.

BACKGROUND Subchorionic hematoma (SCH) can lead to blood accumulation and potentially affect pregnancy outcomes. Despite being a relatively common finding in early pregnancy, the effects of SCH on pregnancy outcomes such as miscarriage, stillbirth, and preterm birth remain debated. This study aims to address these gaps by systematically evaluating the influence of SCH-related clinical factors on pregnancy outcomes using robust analytical techniques.

Exosomal tRF-1003 induces angiogenesis via regulating the HIF1α/VEGF signaling in multiple myeloma.

Background: Multiple myeloma (MM) remains a therapeutically challenging hematologic malignancy characterized by frequent relapse and disease progression. Angiogenesis regulated by non-coding RNAs plays a vital role in MM pathogenesis. Despite the potential clinical applications of tsRNAs, the specific mechanisms by which they contribute to MM progression, particularly through angiogenesis within the bone marrow microenvironment, remain elusive.

The matrix stiffness is increased in the eutopic endometrium of adenomyosis patients: a study based on atomic force microscopy and histochemistry.

Previous ultrasound studies suggest that patients with adenomyosis (AM) exhibit increased uterine cavity stiffness, although direct evidence regarding extracellular matrix (ECM) content and its specific impact on endometrial stiffness remains limited. This study utilized atomic force microscopy to directly measure endometrial stiffness and collagen morphology, enabling a detailed analysis of the endometrium's mechanical properties: through this approach, we established direct evidence of increased endometrial stiffness and fibrosis in patients with AM. Endometrial specimens were also stained with Picrosirius red or Masson's trichrome to quantify fibrosis, and additional analyses assessed α-SMA and Ki-67 expression.

RNF38 promotes gilteritinib resistance in acute myeloid leukemia via inducing autophagy by regulating ubiquitination of LMX1A.

Background: Gilteritinib is a commonly used targeted drug for acute myeloid leukemia (AML), but the emergence of gilteritinib resistance greatly reduces the therapeutic effect. RING finger protein 38 (RNF38), a protein with RING Finger domain and E3 ubiquitin ligase activity, has been implicated in tumorigenesis and drug resistance. However, the role and mechanism of RNF38 in the gilteritinib resistance of AML remains unclear.

General-purpose machine-learned potential for 16 elemental metals and their alloys.

Machine-learned potentials (MLPs) have exhibited remarkable accuracy, yet the lack of general-purpose MLPs for a broad spectrum of elements and their alloys limits their applicability. Here, we present a promising approach for constructing a unified general-purpose MLP for numerous elements, demonstrated through a model (UNEP-v1) for 16 elemental metals and their alloys. To achieve a complete representation of the chemical space, we show, via principal component analysis and diverse test datasets, that employing one-component and two-component systems suffices.

Optical terahertz metamaterial switch controlled via high-stability CsPbBr microcrystals.

Dynamic control of terahertz metamaterials using thin organic perovskite active layers has been extensively researched. However, the preparation of organic perovskite devices requires strict environmental conditions, and the devices are prone to hydrolysis in air, which reduces performance. Herein, we report an optical terahertz metamaterial switch controlled via hybridization with high-stability CsPbBr microcrystals prepared through precipitation from a water-dimethylformamide (DMF) mixed-solution.

Cu-Doped V-Based MOF Derivative VO@Cu-VMOF as a Cathodic Catalyst for Electro-Fenton Degradation of Antibiotics.

In this study, the VO@5%Cu-VMOF/graphite felt (GF) is prepared as an electro-Fenton cathode via hydrothermal process and low-temperature carbonization for efficient antibiotics degradation. The VO@5%Cu-VMOF/GF cathode exhibit great ciprofloxacin (CIP) degradation performance over the pH range of 2.1-7.

HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS.

Oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) are key bioenergetics pathways. The machineries for both processes are localized in mitochondria. Secondary OXPHOS defects have been documented in patients with primary FAO deficiencies, and vice versa.

Radiomics Biomarkers to Predict Checkpoint Inhibitor Pneumonitis in Non-small Cell Lung Cancer.

Rationale And Objectives: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC). However, immune-related adverse events still occur, of which checkpoint inhibitor pneumonitis (CIP) is the most common. We aimed to construct and validate a contrast-enhanced computed tomography-based radiomic nomogram to predict the probability of CIP before ICIs treatment in NSCLC.

Calix[6]arene-Functionalized Photonic Hydrogel Biosensor for Naked-Eye Cholesterol Detection Based on Supramolecular Host-Guest Interactions.

Cholesterol (CHO) is an essential constituent of human cellular tissues and a crucial activity indicator for the clinical diagnosis and prevention of various diseases. Abnormal CHO levels can lead to various cardiovascular diseases, including coronary heart disease, cerebral thrombosis, and atherosclerosis. Thus, developing simple and effective methods for CHO detection is of great significance.

Modulation of empathic abilities by the interplay between estrogen receptors and arginine vasopressin.

This review examines the complex interactions between estrogen receptors α and β (ERα and ERβ) and arginine vasopressin (AVP), delving into their significant roles in modulating empathy, a critical psychological component in human social dynamics. Empathy, integrating affective and cognitive elements, is anchored in neural regions like the amygdala and prefrontal cortex. ERα and ERβ, pivotal in estrogen regulation, influence neurotransmitter dynamics and neural network activities, crucial for empathic development.

Perceptions of Older People in Nursing Facilities About Advance Care Planning: A Systematic Review.

Background: With the ageing of the population intensifying, the implementation of advance care planning (ACP) in nursing facilities is especially crucial.

Objective: This study aimed to search and synthesise qualitative studies exploring the perspectives of older people in nursing facilities about ACP discussions.

Methods: The researchers conducted searches of PubMed, Web of Science, Cochrane Library, CNKI, Wanfang, VIP and CBM between the time of inception and October 2023.

Molecular Mechanisms for the Selective Transport of Dichlorofluorescein by Human Organic Anion Transporting Polypeptide 1B1.

Human organic anion transporting polypeptide (OATP) 1B1 and 1B3 are two highly homologous liver-specific uptake transporters. However, 2',7'-dichlorofluorescein (DCF) is preferably transported by OATP1B1. In the present study, the molecular mechanisms for the selective transport of DCF by OATP1B1 were investigated by constructing and characterizing an array of OATP1B1/1B3 chimeras and site-directed mutagenesis.

Milk vetch returning combined with lime materials alleviates soil cadmium contamination and improves rice quality in soil-rice system.

Milk vetch (Astragalus sinicus L.) returning and lime materials is employed as an effective strategy for remediating cadmium (Cd)-contaminated paddy fields. However, the combined effects of them on alleviating Cd pollution and the underlying mechanisms remain poorly explored.

Co-doped bismuth vanadate/zinc tungstate heterojunction with dual internal electric fields for efficient photocatalytic reduction of carbon dioxide.

Enhanced carriers separation on photocatalysts is crucial for improving photocatalytic activity. In this paper, the Co-doped BiVO/ZnWO S-scheme heterojunctions were constructed to induce double internal electric fields (IEFs) for enhancing charges separation and transfer for efficient photocatalytic reduction of CO. The photocatalytic CO reduction efficiencies of the heterojunctions were significantly enhanced as compared with the counterparts.

Poly(ionic liquid)s: A Promising Matrix for Thermal Interface Materials.

The swift progression of high-density chiplet packaging, propelled by the artificial intelligence revolution, has precipitated a critical need for high-performance chip-scale thermal interface materials (TIMs). The elevated thermal resistance, limited interfacial adhesion, and mechanical flexibility intrinsic to silicone systems present a substantial challenge in meeting reliability standards amidst chip warpage. This particular matter underscores a significant performance bottleneck within existing high-end TIMs.

Human organic anion transporting polypeptide 1B3 (OATP1B3) is more heavily N-glycosylated than OATP1B1 in extracellular loops 2 and 5.

Human organic anion transporting polypeptide 1B3 (OATP1B3) and 1B1 are two liver-specific and highly homologous uptake transporters, whose structures consist of 12 transmembrane domains. The present study showed that OATP1B3 is more heavily N-glycosylated than OATP1B1 in extracellular loop 2 (EL2) and EL5. OATP1B3 has six N-glycosylation sites, namely N134, N145, N151, N445, N503, and N516, which is twice of that of OATP1B1.

A forecasting model for suitable dental implantation in canine mandibular premolar region based on finite element analysis.

In recent years, dental implants have become a trend in the treatment of human patients with missing teeth, which may also be an acceptable method for companion animal dentistry. However, there is a gap challenge in determining appropriate implant sizes for different dog breeds and human. In this study, we utilized skull computed tomography data to create three-dimensional models of the mandibles of dogs in different sizes.

Microplastics exposure disrupts nephrogenesis and induces renal toxicity in human iPSC-derived kidney organoids.

Microplastics (MPs) have emerged as a pervasive environmental pollutant of global concern. Their detection within the human placenta and fetal organs has prompted apprehension regarding the potential hazards of MPs during early organogenesis. The kidney, a vital multifunctional organ, is susceptible to damage from MPs in adulthood.

Dual Attention-Based 3D U-Net Liver Segmentation Algorithm on CT Images.

The liver is a vital organ in the human body, and CT images can intuitively display its morphology. Physicians rely on liver CT images to observe its anatomical structure and areas of pathology, providing evidence for clinical diagnosis and treatment planning. To assist physicians in making accurate judgments, artificial intelligence techniques are adopted.

The combination of modified acupuncture needle and melittin hydrogel as a novel therapeutic approach for rheumatoid arthritis treatment.

Rheumatoid arthritis (RA) involves chronic joint inflammation. Combining acupuncture and medication for RA treatment faces challenges like spatiotemporal variability, limited drug loading in acupuncture needles, and premature or untargeted drug release. Here, we designed a new type of tubular acupuncture needles, with an etched hollow honeycomb-like structure to enable the high loading of therapeutics, integrating the traditional acupuncture and drug repository into an all-in-one therapeutic platform.