A peptide encoded by LINC00944 suppresses the growth of melanoma cells by diminishing EP400-MYC interaction.

The peptides encoded by long noncoding RNAs (lncRNAs) have been shown to participate in cancer pathogenesis. In this study, lncRNA LINC00944 was validated to encode an endogenous 102-amino acid (aa) small peptide (named LINC00944 peptide). Functionally, LINC00944 peptide exerted an anti-growth effect in melanoma cells in vitro.

UV radiation enhanced encapsulation of superparamagnetic iron oxide nanoparticles (MNPs) in microparticles derived from tumor repopulating cells.

Extracellular vesicles (EVs) such as microparticles secreted by the cells can be manipulated and used for delivering therapeutic drugs to target and eradicate cancer cells. However, high encapsulation efficiency and mass production of the microparticles remain difficult to achieve. Efficient and targeted delivery to cancer cells is another hurdle to be addressed.

Arabinogalactan from Cynanchum atratum induces tolerogenic dendritic cells in gut to restrain autoimmune response and alleviate collagen-induced arthritis in mice.

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by multiple joints lesions. Tolerogenic dendritic cells (tolDCs) play crucial roles in maintaining immune homeostasis. The immunomodulatory activity of plant-derived arabinogalactan (AGs) has been well investigated, however, whether AGs could suppress autoimmune responses by inducing tolDCs is remain unclear.

Effect of Depositional Environment on the Occurrence of 17α(H)-Diahopanes in Triassic Lacustrine Sediments from the Ordos Basin, NW China.

In this study, an abundant 17α(H)-diahopanes has been observed in the sediments from the seventh member of the Triassic Yanchang Formation in the central part of the Ordos Basin. The results show that the maturity has a minor contribution to the relative abundance of 17α(H)-diahopanes as the maturity of the samples are similar and fall into a limited range in the selected samples from the study area. The C-C regular steranes distributions of the samples are also similar and shaped a "V" pattern, indicating a mixture of aquatic organisms and terrigenous organic matter, which may be not responsible for the different 17α(H)-diahopanes distributions.

Large-scale Conformational Changes of Diindole Functional Groups Driven by Cation-π Interactions and the Toughening Mechanism of Thermosets.

This is described that a new concept for the design of toughening supramolecular thermosets by incorporating diindole groups, which are functionalized via cation-π interactions in covalently crosslinked networks. Large-scale conformational changes of the diindole functional groups could occur under external forces, endowing the thermosets with excellent toughening properties.

Induction of ferroptosis by SIRT1 knockdown alleviates cytarabine resistance in acute myeloid leukemia by activating the HMGB1/ACSL4 pathway.

Resistance to cytarabine is a major obstacle to the successful treatment of acute myeloid leukemia (AML). The present study aimed to explore the mechanism by which sirtuin 1 (SIRT1) reverses the cytarabine resistance of leukemia cells. Cell viability was investigated using the EdU proliferation assay.

The nearly complete mitochondrial genome of the door snail (Stylommatophora: Clausiliidae) and phylogenetic analysis.

The family Clausiliidae was proposed as a model for studying the diversity of breeding biology in land snails. This study assembled a nearly complete mitogenome (15,417 bp) for the clausiliid snail . The mitogenome includes 13 protein-coding genes (PCGs), two ribosomal RNAs, and 22 transfer RNAs, with a gene order consistent with other clausiliids.

Analysis of Metal-Organic Framework and Polyamide Interfaces in Membranes for Water Treatment and Antibacterial Applications.

Integrating biocidal nanoparticles (NPs) into polyamide (PA) membranes shows promise for enhancing resistance to biofouling. Incorporating techniques can tailor thin-film nanocomposite (TFN) membranes for specific water purification applications. In this study, silver-based metal-organic framework Ag-MOFs (using silver nitrate and 1,3,5-benzentricarboxylic acid as precursors) are incorporated into PA membranes via three different methods: i) incorporation, ii) dip-coating, and iii) in situ ultrasonic techniques.

Single-pixel complex-amplitude imaging based on untrained complex-valued convolutional neural network.

Single-pixel imaging is advancing rapidly in complex-amplitude imaging. However, reconstructing high-quality images demands significant acquisition and heavy computation, making the entire imaging process time-consuming. Here we propose what we believe to be a novel single-pixel complex-amplitude imaging (SCI) scheme using a complex-valued convolutional neural network for image reconstruction.

Peptide-Guided Assembly of Silver Nanoparticles for the Diagnosis of HER2-Positive Breast Cancer.

Peptide-engineered nanoparticles have great potential for biomedical research and application. In this work, we have designed and fabricated an electrochemical biosensor based on peptide-guided assembly of silver nanoparticles (AgNPs), in which a peptide is endowed with dual functions to recognize target and guide assembly of AgNPs. As a proof of concept, the performance of this biosensor is validated by quantifying human epidermal growth factor receptor 2 (HER2) protein.

Performance prediction of sintered NdFeB magnet using multi-head attention regression models.

The preparation of sintered NdFeB magnets is complex, time-consuming, and costly. Data-driven machine learning methods can enhance the efficiency of material synthesis and performance optimization. Traditional machine learning models based on mathematical and statistical principles are effective for structured data and offer high interpretability.

Effect of high amylose starch on the incorporation of thymol into electrospun pullulan nanofibers.

High amylose starch (HAMS) was employed as an effective carrier to incorporate thymol within pullulan nanofibers. Aqueous solutions with HAMS concentrations of 0 % - 5 % were investigated to study their effect on the incorporation of thymol during electrospinning. As a result, the loading capacity was significantly improved by the addition of HAMS, increasing from 2.

Predictive value of urine misfolded protein in preeclampsia in twin pregnancies.

Objective: To assess the utility of urinary misfolded proteins (MP) in predicting preeclampsia (PE) in high-risk twin pregnancies.

Methods: A prospective study was conducted on 600 high-risk twin pregnancies at Shanghai First Maternity and Infant Hospital from March to August 2021. Clinical data were collected, and urinary MP levels were measured.

Transition of new residents to nursing homes: A qualitative meta-synthesis.

Aim: To synthesize qualitative evidence on the transition experience of new residents to nursing homes.

Methods: A systematic literature search was conducted in PubMed, Embase, CINAHL, China National Knowledge Infrastructure, China Wanfang Database from inception to February 2024. The CASP evaluation for qualitative studies was used for quality appraisal, and meta-aggregation was used in data analysis.

Conventional and biodegradable microplastics affected arsenic mobility and methylation in paddy soils through distinct chemical-microbial pathways.

The presence of microplastics (MPs) in paddy soil has become a growing concern, yet the influence of MPs on arsenic (As) dynamics in paddy soil remains largely unexplored. A 98-day microcosm experiment was conducted to investigate the impact of MPs on As behavior in As-contaminated paddy soil. The results revealed that conventional microplastics (CMPs) reduced As concentration in porewater by 25-38 %, but substantially increased the percentage of methylated As (% MeAs) in soil by 8-23 times under 5 % dosages after 98-day incubation.

Etoposide targets 2A protease to inhibit enterovirus 71 replication.

Enterovirus 71 (EV71) is a major pathogen that causes hand, foot, and mouth disease (HFMD) in infants and children. Notably, no clinically approved drugs specifically target EV71. The EV71 2A protease (2A), a cysteine protease produced by the virus, is essential for the virus' replication and has a significant impact on the functioning of host cells.

Characterizing PANoptosis gene signature in prognosis and chemosensitivity of colorectal cancer.

Background: PANoptosis is a cell death pathway involved in pyroptosis, apoptosis and necrosis, and plays a key role in the development of malignant tumors. However, the molecular signature of PANoptosis in colorectal cancer (CRC) prognosis has not been thoroughly explored. The present study aimed to develop a novel prognostic model based on PANoptosis-related genes in CRC.

Automated measurement and correlation analysis of fundus tessellation and optic disc characteristics in myopia.

This study aims to quantify fundus tessellated (FT) density and optic disc (OD) morphology using deep learning (DL) techniques and to investigate the correlations between these fundus characteristics and refractive function in young patients with myopia. We constructed two DL-based segmentation models to delineate the FT, OD, peripapillary atrophy (PPA), and macula at a pixel-level resolution. The study sought to identify differences in fundus characteristics between eyes categorized as having high myopia versus mild or moderate myopia.

The role of the rhizobiome recruited by root exudates in plant disease resistance: current status and future directions.

Root exudates serve as a bridge connecting plant roots and rhizosphere microbes, playing a key role in influencing the assembly and function of the rhizobiome. Recent studies have fully elucidated the role of root exudates in recruiting rhizosphere microbes to enhance plant performance, particularly in terms of plant resistance to soil-borne pathogens; however, it should be noted that the composition and amount of root exudates are primarily quantitative traits regulated by a large number of genes in plants. As a result, there are knowledge gaps in understanding the contribution of the rhizobiome to soil-borne plant disease resistance and the ternary link of plant genes, root exudates, and disease resistance-associated microbes.

A Case Report of Infection After Lumbar Spinal Fixation and Fusion.

(MC) is an aerobic Gram-negative cocci known to cause respiratory tract infections in humans as an opportunistic pathogen, with infections in other body parts being rare. This case involves an elderly female patient with a medical history of hypertension, type 2 diabetes, coronary heart disease, and osteoporosis. Following coronary angiography and lumbar spine surgery prompted by lower back and left lower limb pain, the patient developed persistent pus discharge from the lumbar spine wound post-surgery, which did not respond to conventional anti-infection therapy, leading to her transfer to our hospital.

Exosomes derived from IFNγ-stimulated mesenchymal stem cells protect photoreceptors in RCS rats by restoring immune homeostasis through tsRNAs.

Background: Retinitis pigmentosa is a neurodegenerative disease with major pathologies of photoreceptor apoptosis and immune imbalance. Mesenchymal stem cells (MSCs) have been approved for clinical application for treating various immune-related or neurodegenerative diseases. The objective of this research was to investigate the mechanisms underlying the safeguarding effects of MSC-derived exosomes in a retinal degenerative disease model.