Protein-energy wasting (PEW) facilitates major adverse clinical outcomes in chronic renal failure (CRF), with current therapies not suitable for all patients. Faecalibacterium prausnitzii (F. prausnitzii) can alleviate chronic kidney disease, with unclear effects and mechanisms on CRF with PEW.
View Article and Find Full Text PDFLiver fibrosis is an inadequate response to tissue stress, with reactive oxygen species (ROS) overproduction in activated hepatic stellate cells (aHSCs). Bromodomain-containing protein 4 (BRD4) was found to be upregulated in aHSCs and has been identified as an effective target for the treatment of liver fibrosis. However, inhibition of BRD4 with traditional kinase inhibitors achieved only limited success because of its low therapeutic efficiency.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
January 2025
Efficient data utilization is crucial for advancing 3D scene understanding in autonomous driving, where reliance on heavily human-annotated LiDAR point clouds challenges fully supervised methods. Addressing this, our study extends into semi-supervised learning for LiDAR semantic segmentation, leveraging the intrinsic spatial priors of driving scenes and multi-sensor complements to augment the efficacy of unlabeled datasets. We introduce LaserMix++, an evolved framework that integrates laser beam manipulations from disparate LiDAR scans and incorporates LiDAR-camera correspondences to further assist data-efficient learning.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
January 2025
Recent advancements in bird's eye view (BEV) representations have shown remarkable promise for in-vehicle 3D perception. However, while these methods have achieved impressive results on standard benchmarks, their robustness in varied conditions remains insufficiently assessed. In this study, we present RoboBEV, an extensive benchmark suite designed to evaluate the resilience of BEV algorithms.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
April 2025
Generating diverse and high-quality 3D assets automatically poses a fundamental yet challenging task in 3D computer vision. Despite extensive efforts in 3D generation, existing optimization-based approaches struggle to produce large-scale 3D assets efficiently. Meanwhile, feed-forward methods often focus on generating only a single category or a few categories, limiting their generalizability.
View Article and Find Full Text PDFLight-harvesting chlorophyll a/b-binding (LHC) proteins, as the antenna complex, collect and transfer light energy to the reaction centers of PSII. They are crucial for abiotic stress responses, especially in the photoprotection under cold stress. However, members of the LHC gene family in tomato (Solanum lycopersicum L.
View Article and Find Full Text PDFBackground: As ferroptosis is a key factor in renal fibrosis (RF), iron deposition monitoring may help evaluating RF. The capability of quantitative susceptibility mapping (QSM) for detecting iron deposition in RF remains uncertain.
Purpose: To investigate the potential of QSM to detect iron deposition in RF.
Background And Aim: Zhilong Huoxue Tongyu Capsule (ZL capsule) has been demonstrated to be an effective and widely-used traditional Chinese medicine (TCM) formula for the treatment of various diseases, especially for atherosclerosis (AS) related cardiovascular and cerebrovascular diseases. Reversal of endothelial-mesenchymal transition (EndMT) plays a crucial role in the cure of AS. But the curative impact of ZL capsule on EndMT remains obscure during the development of AS.
View Article and Find Full Text PDFMulti-photon polymerization is a well-established, yet actively developing, additive manufacturing technique for 3D printing on the micro/nanoscale. Like all additive manufacturing techniques, determining the process parameters necessary to achieve dimensional accuracy for a structure 3D printed using this method is not always straightforward and can require time-consuming experimentation. In this work, an active machine learning based framework is presented for determining optimal process parameters for the recently developed, high-speed, layer-by-layer continuous projection 3D printing process.
View Article and Find Full Text PDFThe purpose of the article is to determine whether differentiation and enhanced CT features can preoperatively predict microvascular/nerve invasion in locally advanced gastric cancer. Retrospective analysis of the CT and pathological data of 325 patients with locally advanced gastric cancer confirmed by pathology in our hospital from July 2011 to August 2023. The patient's age, gender, tumor location, T stage, N stage, TNM stage, differentiation, Lauren classification, as well as tumor thickness, tumor longest diameter, plain CT value, arterial CT value, venous CT value, arterial phase enhancement rate, and venous phase enhancement rate were assessed.
View Article and Find Full Text PDFThe photocurrent-polarity-switching signal transduction strategy has provided an effective approach to improve the performance of photoelectrochemical (PEC) biosensors. Herein, we prepared a MXene/CdS nanocomposite based PEC biosensor and combined it with the polymerization and isomerization cyclic amplification (PICA)-assisted capture of a Fe and Cu co-coordinating 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TFC) based signal probe to develop a novel photocurrent-polarity-switching PEC biosensing method for the detection of kanamycin antibiotic. The PICA arose from the aptamer recognition-triggered release of an Mg-dependent DNAzyme (MNAzyme) strand to cleave its substrate.
View Article and Find Full Text PDFObjective: To analyze the value of combining computed tomography (CT) with serum tumor markers in the differential diagnosis of benign and malignant solitary pulmonary nodules (SPNs).
Methods: The case data of 267 patients diagnosed with SPNs in the First Affiliated Hospital of Zhengzhou University from March 2020 to January 2023 were retrospectively analyzed. All individuals diagnosed with coronavirus disease 2019 (COVID-19) were confirmed via respiratory specimen viral nucleic acid testing.
Integrating flexible piezoelectric nanogenerators (PENGs) into wearable and portable electronics offers promising prospects for motion monitoring. However, it remains a significant challenge to develop environmentally friendly PENGs using biodegradable and cost-effective natural polymers for mechanical energy harvesting and self-powered sensing. Herein, reduced graphene oxide (rGO) and barium titanate (BTO) were introduced into regenerated cellulose pulp to fabricate a composite porous film-based PENG.
View Article and Find Full Text PDFLiver fibrosis is a chronic pathological process in which the abnormal proliferation of connective tissue is induced by various pathogenic factors. During the process of fibrosis, excessive angiogenesis is observed. Physiological angiogenesis has the potential to impede the progression of liver fibrosis through augmenting matrix metalloenzyme activity; however, pathological angiogenesis can exacerbate liver fibrosis by promoting collagen accumulation.
View Article and Find Full Text PDFIn the agricultural lands of China, polyethylene is the main component of microplastics (MPs), with characteristics such as small size, wide distribution, easy accumulation, and difficult degradation. Therefore, it may have an impact on the elemental cycling process of the soil. On the basis of reviewing the key literatures in the past few years, this study systematically analyzed and summarized the key factors and processes of the polyethylene microplastics (PE-MPs) affecting soil nitrogen transformation.
View Article and Find Full Text PDFBackground: No studies have updated the epidemiologic changes in non-rheumatic degenerative mitral valve disease (DMVD) since 2019, thus this study utilized data from the Global Study of Diseases, Injuries, and Risk Factors 2019 (GBD2019) to assess the burden of DMVD in 204 countries and territories over the period 1990-2019, as well as changes in the prevalence, incidence, deaths and changes in disability-adjusted life years (DALYs).
Methods: Using the results from the GBD2019, analyzing the incidence, prevalence, deaths, and DALYs rates, as well as their age-standardized rates (ASR). Based on the human development index (HDI), the socio-demographic index (SDI), age, and sex.
Radiation-free one-stage bedside endoscopic stone removal and biliary drainage for severe acute cholangitis (SAC) caused by choledocholithiasis in intensive care unit (ICU) has not been reported. Herein, we introduce our preliminary experience of such intervention. Radiation-free bedside digital cholangioscope-assisted one-stage endoscopic stone removal and biliary drainage was performed in an urgent manner.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
Aqueous zinc ion batteries (AZIBs) have attracted much attention for their safety, low cost and high theoretical capacity. Nevertheless, Zn dendrites and the adverse reactions such as corrosion, hydrogen evolution and passivation on the anode affect the cycle life and stability of AZIBs. Herein, superabsorbent starch (SS) was employed on Zn foil to form an artificial interface protection layer, which inhibited the formation of dendrites by guiding the uniform deposition of Zn.
View Article and Find Full Text PDFObjectives: Metabolic dysfunction-associated fatty liver disease (MAFLD), a globally prevalent disease, is closely linked to insulin resistance (IR). Physical activity (PA) is closely linked to both MAFLD and IR. We aim to explore the dose-response relationship between metabolic score for IR (METS-IR)/homeostasis model assessment of IR (HOMA-IR) and MAFLD, and investigate the relationship between PA, IR and MAFLD.
View Article and Find Full Text PDFAsiatic acid (AA) is a pentacyclic triterpene derived from the traditional medicine . It is known for its anti-inflammatory, antioxidant, and lipid-regulating properties. Though previous studies have suggested its potential therapeutic benefits for atherosclerosis, its pharmacological mechanism is unclear.
View Article and Find Full Text PDFThis paper aims to explore the anti-inflammatory mechanism of Saracae Cortex by using network pharmacology and molecular docking methods and verify it through the inflammation model of zebrafish. The effective components, potential core targets, and signaling pathways of Saracae Cortex were obtained by using network pharmacology. A lipopolysaccharide(LPS)-induced inflammation model of zebrafish was established to evaluate the anti-inflammatory activity of aqueous extract and 70% ethanol extract of Saracae Cortex with cell apoptosis rate and reactive oxygen species(ROS) production rate as indicators.
View Article and Find Full Text PDFCharge transfer efficiencies in all-inorganic lead halide perovskite nanocrystals (NCs) are crucial for applications in photovoltaics and photocatalysis. Herein, CsPbBr NCs with different sizes are synthesized by varying the ligand contents of didodecyl dimethylammonium bromide at room temperature. Adding benzoquinone (BQ) molecules leads to a decrease in the PL intensities and PL decay times in NCs.
View Article and Find Full Text PDFJiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral ischemic symptoms in clinical practice, but the underlying mechanisms are unclear. In this study, we investigated the mechanisms of action of JXCG in the treatment of IS by combining metabolomics with network pharmacology.
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