Mechanical and Microstructural Performance of UHPC with Recycled Aggregates Modified by Basalt Fiber and Nanoalumina at High Temperatures.

This study investigates the mechanical properties and microstructure of basalt fiber (BF) and nanoalumina (NA)-modified ultra-high-performance concrete with recycled aggregates (UHPC-RA) under high-temperature conditions. The effects of different replacement rates of recycled aggregates (RAs), BF content, and NA content on the compressive strength, splitting tensile strength, and elastic modulus were evaluated at ambient temperatures and after exposure to 200 °C, 400 °C, 600 °C, and 800 °C. The results show that mechanical properties decrease with temperature rise, but specimens containing BF exhibited improved crack resistance and better high-temperature integrity.

Machine learning-based non-invasive continuous dynamic monitoring of human core temperature with wearable dual temperature sensors.

Objective: Due to the growing demand for personal health monitoring in extreme environments, continuous monitoring of core temperature has become increasingly important. Traditional monitoring methods, such as mercury thermometers and infrared thermometers, may have limitations in tracking real-time fluctuations in core temperature, especially in special application scenarios such as firefighting, military, and aerospace. This study aims to develop a non-invasive, continuous core temperature prediction model based on machine learning, addressing the limitations of traditional methods in extreme environments.

Tuning the Near-Infrared Aggregate of a Multicationic Photosensitizer through Molecular Coassembly for Symbiotic Photothermal Therapy and Chemotherapy.

Cationic photosensitizers (PSs) offer many intriguing advantages, in addition to generating heat or reactive oxygen species for cancer phototherapy. However, the preparation of cationic PSs with enhanced near-infrared (NIR) absorption remains a significant challenge. In this work, we have synthesized a PS TPBBT, which incorporates a strong electron-withdrawing unit, benzobisthiadiazole, and four terminal pyridinium groups.

Formation of electron-deficient Ni in a Nb/NiFe-layered double hydroxide nanoarray electrochemical activation for efficient water oxidation.

The intrinsically sluggish kinetics of the oxygen evolution reaction (OER) at the anode poses a formidable challenge to the industrial application of water electrolysis, although NiFe-based oxides and hydroxides have emerged as promising anodic candidates. Within this framework, we report the synthesis of Nb-doped NiFe-layered double hydroxides (Nb/NiFe-LDH) a straightforward one-step hydrothermal approach. Notably, Nb doping maintained the structural integrity of the NiFe-LDH framework and it enhanced the valence state of the active Ni species during the electrochemical activation process, which accelerated the concomitant reconstruction kinetics of the LDH phase.

Biofilm-Induced Critical Flux in Dead-End Ultrafiltration Processes: Phenomenon, Mechanism, and Economic and Environmental Benefits.

The concept of critical flux, introduced by R.W. Field, defines the flux below which the filtration resistance remains constant over time.

Targeted Raman Visualization and Mitigation of α-Synuclein Amyloidogenesis in Living Zebrafish by a Nanobody-Decorated Polydiacetylene.

α-Synuclein (α-Syn) amyloidogenesis is considered a promising diagnostic marker and therapeutic target for Parkinson's disease (PD). Simultaneously visualizing and mitigating α-Syn amyloidogenesis are essential for future PD theranostics, yet they continue to pose an insurmountable challenge. This study have herein developed a nanobody-decorated polydiacetylene to approach a straightforward solution.

Using 18F-FDG PET/CT to Predict PD-L1 Expression in NSCLC via Metabolic Tumor Heterogeneity.

Objectives: The purpose of this study is to evaluate the effectiveness of using F-18 FDG PET/CT metabolic heterogeneity to assess the PD-L1 expression in primary tumors.

Methods: Data from 103 NSCLC patients undergoing F-18 FDG PET/CT was collected. PD-L1 expression was verified via biopsy or surgical specimens.

Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer risk.

Background: Germline mutations in numerous genes, particularly tumor suppressor genes, markedly heighten the risk of various cancers, including lung cancer, which is the leading cause of cancer-related deaths worldwide. Despite extensive research on well-known genes like BRCA1, BRCA2, and mismatch repair genes, many genetic factors contributing to cancer susceptibility remain unidentified.

Methods: This study reviewed sequencing data from 4,934 Chinese lung cancer patients.

Therapeutic Effects and Mechanisms of Icaritin in Parkinson's Disease.

Parkinson's Disease (PD) is a neurodegenerative disorder of the central nervous system (CNS). Given the increasing age of the general population, PD has emerged as a significant public health and societal concern, impacting both individual well-being and socioeconomic progress. The present interventions have proven insufficient in impeding the progressive nature of PD.

The Role and Molecular Mechanism of Icaritin in the Treatment of Alzheimer's Disease.

Alzheimer's disease (AD), a degenerative disease of the central nervous system, affects approximately 70 million individuals worldwide. As the number of elderly in the population increases, the prevalence and incidence of AD are increasing annually. Although the drugs are currently used to alleviate certain cognitive symptoms, their overall therapeutic efficacy remains unclear.

Role of F-PSMA-1007 PET/CT-derived quantitative volumetric tumor parameters in cytoreductive radical prostatectomy selection for patients with low-volume metastatic hormone-sensitive prostate cancer: a retrospective study.

Background: Cytoreductive radical prostatectomy (cRP) has emerged as a promising therapeutic approach for low-volume metastatic hormone-sensitive prostate cancer (mHSPC), but the best candidates for cRP are still unknown. This study aims to explore the potential value of F-PSMA-1007 PET/CT-derived quantitative volumetric tumor parameters in cRP treatment selection among patients with low-volume mHSPC.

Methods: A total of 122 patients with primary low-volume mHSPC who underwent F-PSMA-1007 PET/CT followed by systemic therapy alone or plus cRP were included.

Cancer theragnostics: closing the loop for advanced personalized cancer treatment through the platform integration of therapeutics and diagnostics.

Cancer continues to be one of the leading causes of death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, and surgery have limitations. RNA therapy and cancer vaccines hold considerable promise as an alternative to conventional therapies for their ability to enable personalized therapy with improved efficacy and reduced side effects. The principal approach of cancer vaccines is to induce a specific immune response against cancer cells.

Highly Sensitive Non-Dispersive Infrared Gas Sensor with Innovative Application for Monitoring Carbon Dioxide Emissions from Lithium-Ion Battery Thermal Runaway.

The safety of power batteries in the automotive industry is of paramount importance and cannot be emphasized enough. As lithium-ion battery technology continues to evolve, the energy density of these batteries increases, thereby amplifying the potential risks linked to battery failures. This study explores pivotal safety challenges within the electric vehicle sector, with a particular focus on thermal runaway and gas emissions originating from lithium-ion batteries.

Network analysis of the symptoms of posttraumatic stress disorder in patients undergoing chemotherapy for colorectal cancer.

Objective: In this study, we examine the network structure of posttraumatic stress disorder (PTSD), including core symptoms and strong edges in patients undergoing chemotherapy for colorectal cancer in China, and lay the groundwork for targeted psychological interventions for these patients.

Methods: This study included 360 colorectal cancer patients receiving chemotherapy at a third-class hospital in Wuxi, China, from November 2023 to June 2024. The severity of each item of PTSD was assessed using the DSM-5 Checklist (PCL-5).

Toward one-step As(III) removal in ultrafiltration with in situ BioMnO cake layer: Mechanism and feasibility insights.

Inorganic arsenic (As) is one of the most significant chemical contaminants in drinking water worldwide. Although membrane-based technologies are commonly used for As removal, they often encounter challenges including complex operation, high energy consumption, and the need for chemical addition. To address these challenges, we proposed a one-step ultrafiltration (UF) process empowered by in situ biogenic manganese oxides (BioMnO) cake layers without any additional chemicals, to treat source water contaminated with both As and manganese (Mn).

An Investigation into High-Accuracy and Energy-Efficient Novel Capacitive MEMS for Tire Pressure Sensor Application.

Tire pressure monitoring systems (TPMSs) are essential for maintaining driving safety by continuously monitoring critical tire parameters, such as pressure and temperature, in real time during vehicle operation. Among these parameters, tire pressure is the most significant, necessitating the use of highly precise, cost-effective, and energy-efficient sensing technologies. With the rapid advancements in micro-electro-mechanical system (MEMS) technology, modern automotive sensing and monitoring systems increasingly rely on MEMS sensors due to their compact size, low cost, and low power consumption.

A normative database of Swahili-Chinese paired associates.

Over the past few decades, Swahili-English and Lithuanian-English word pair databases have been extensively utilized in research on learning and memory. However, these normative databases are specifically designed for generating study stimuli in learning and memory research involving native (or fluent) English speakers. Consequently, they are not suitable for investigations that encompass populations whose first language is not English, such as Chinese individuals.

Light-Driven Hybrid Nanoreactor Harnessing the Synergy of Carboxysomes and Organic Frameworks for Efficient Hydrogen Production.

Synthetic photobiocatalysts are promising catalysts for valuable chemical transformations by harnessing solar energy inspired by natural photosynthesis. However, the synergistic integration of all of the components for efficient light harvesting, cascade electron transfer, and efficient biocatalytic reactions presents a formidable challenge. In particular, replicating intricate multiscale hierarchical assembly and functional segregation involved in natural photosystems, such as photosystems I and II, remains particularly demanding within artificial structures.

Metal-Organic Framework-Based Cascade Catalysis-Enabled Fluorescent ELISA with Higher Enzymatic Stability for Zearalenone Detection in Maize.

The enzyme-linked immunosorbent assay (ELISA) stands as one of the most frequently employed rapid detection techniques for both chemical and biological contaminants. Horseradish peroxidase (HRP) and hydrogen peroxide (HO), serving as signal generators, play indispensable roles throughout the entire ELISA process. However, HRP and HO exhibit high sensitivity to elevated temperatures, hindering the broader utilization and transportation of ELISA.

The accuracy of fluorine 18-labelled prostate-specific membrane antigen PET/CT and MRI for diagnosis of prostate cancer in PSA grey zone.

Background: The diagnostic utility of prostate biopsy is limited for prostate cancer (PCa) in the prostate-specific antigen (PSA) grey zone. This study aims to evaluate the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) for PSA grey zone PCa and clinically significant PCa (csPCa).

Methods: A total of 82 patients with PSA levels ranging from 4 to 10 ng/mL who underwent F-PSMA-1007 PET/CT, mpMRI, and prostate biopsy were prospectively enrolled.

[Clinical significance of antiphospholipid antibodies in Behcet disease with thrombosis].

Objective: To investigate the distribution and clinical significance of antiphospholipid antibody (aPL) in patients with Behcet disease (BD).

Methods: A total of 222 BD patients admitted to the Department of Rheumatology and Immunology in Peking University People' s Hospital from February 2008 to July 2024 were selected retrospectively. General data of the patients including age and gender were collec-ted.

Interface gypsum deposition in flow-electrode CDI treating brackish water: Impacts and mechanisms.

Flow-electrode capacitive deionization (FCDI) is a promising electrically driven technology for brackish water desalination, but it suffers from scaling issues in the concentrate chamber when treating brackish water with high levels of SO and Ca. In addition, how the key components (e.g.

Modified Carba PBP test for rapid detection and differentiation between different classes of carbapenemases in Enterobacterales.

An advanced biochemical assay named modified Carba PBP test was innovated to identify and differentiate distinct categories of clinically significant carbapenemases (Ambler classes A, B, and D) within the Enterobacterales. The mechanism of mCarba PBP hinges on two core attributes: (i) the hydrolysis of the meropenem substrate by various carbapenemases, (ii) the immobilized penicillin and free meropenem in their affinity to interact with a limited quantity of penicillin-binding protein (PBP). Specific inhibitors for class A (phenylboronic acid, PBA) and class B (ethylenediaminetetraacetic acid, EDTA) were employed to inhibit the hydrolysis activity of carbapenemase and facilitate the classification of carbapenemase classes within 25 min.

Exosomes as novel biomarkers in sepsis and sepsis related organ failure.

Sepsis, a severe and life-threatening condition arising from a dysfunctional host response to infection, presents considerable challenges to the health care system and is characterized by high mortality rates and substantial economic costs. Exosomes have garnered attention as potential diagnostic markers because of their capacity to mirror the pathophysiological milieu of sepsis. This discourse reviews the progression of sepsis classification from Sepsis 1.