Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system.

Numerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously. Herein, monodisperse poly(-isopropylacrylamide) (PNIPAAm) hollow nanocapsules were synthesized at the interface of a water-in-oil (W/O) single emulsion via Shirasu porous glass (SPG) membrane emulsification and UV-initiated polymerization.

A J-Domain Protein J3 Antagonizes ABI5-BINDING PROTEIN2 to Regulate CONSTANS Stability and Flowering Time.

CONSTANS (CO) plays a vital role in activating the expression of the florigen FT during photoperiod-dependent flowering. The diurnal oscillation of CO protein abundance is strictly controlled by daylength and the circadian clock. We showed previously that ABI5-BINDING PROTEIN2 (AFP2) represses CO expression to delay flowering.

Impact of celastrol on mitochondrial dynamics and proliferation in glioblastoma.

Background: Targeting mitochondrial dynamics offers promising strategies for treating glioblastoma multiforme. Celastrol has demonstrated therapeutic effects on various cancers, but its impact on mitochondrial dynamics in glioblastoma multiforme remains largely unknown. We studied the effects of Celastrol on mitochondrial dynamics, redox homeostasis, and the proliferation.

A modified measurement method for functional spinal unit ROM of cervical spine.

The interspinous process motion (ISM) method can provide a more accurate assessment of postoperative subaxial cervical fusion than Cobb angle method which is used more commonly in clinical practice. However, the ISM method presents the measurement results in millimeters which cannot be directly compared with the Cobb angle measurement data. We proposed a modified measurement method for cervical functional spinal unit range of motion  (FSU ROM) and evaluate its repeatability and reliability in measuring the ROM of the surgical segment after cervical artificial disc replacement surgery.

Ecdysterone Alleviates Atherosclerosis by Inhibiting NCF2 and Inhibiting Ferroptosis Mediated by the PI3K/Akt/Nrf2 Pathway.

Ecdysterone (Ecd), an active ingredient in trianthema, has a strong anti-inflammatory effect. This study aimed to explore the potential mechanism by which Ecd improves atherosclerosis (AS). Here, we systematically investigated the mechanism of Ecd in human umbilical vein endothelial cells (HUVECs) treated with oxidised low-density lipoprotein (ox-LDL).

Theoretical investigation of parallel NiO/GaP heterojunction nuclear battery with graphene layer and its time-related performance.

Betavoltaic (BV) batteries are regarded as appealing power sources due to their high energy densities and long lifetimes. However, the low efficiency and maximum output power density of conventional BV batteries due to the self-absorption effect of radioactive sources, which consist of separate beta-radioactive sources and semiconductor absorbers, limit their applications. In this work, we optimized and compared six NiO-related heterojunction nuclear batteries utilizing Monte Carlo software Geant4 and finite element analysis software COMSOL Multiphysics.

On-chip near-infrared multi-gas sensing using chalcogenide anti-resonant hollow-core waveguides.

On-chip infrared spectroscopic gas sensing using a hollow-core anti-resonant reflecting optical waveguide (ARROW) with a large external confinement factor (ECF) was rarely reported due to the complex fabrication process and polarization dependence. Alternatively, we proposed ARROW gas sensors using chalcogenide (ChG) anti-resonant layers which require thermal evaporation and epoxy resin bonding for fabrication instead of the complicated wafer bonding process. Polarization characteristics and ethylene (CH) sensing performance at 1.

Strain-Compensated Quantum Well Asymmetric Waveguide Edge-Emitting Laser Operating at 730 nm.

Semiconductor lasers operating at the 730 nm peak wavelength have diverse applications, including biomedical diagnostics, agricultural lighting, and high-precision sensing. However, quantum well (QW) materials, commonly employed at this wavelength, often fail to simultaneously meet the dual requirements of lattice matching and bandgap alignment. In this study, GaAsP/AlGaInP large strain compensation QW with lattice mismatches of -7.

High-Performance Gate-All-Around Field Effect Transistors Based on Orderly Arrays of Catalytic Si Nanowire Channels.

Gate-all-around field-effect transistors (GAA-FETs) represent the leading-edge channel architecture for constructing state-of-the-art high-performance FETs. Despite the advantages offered by the GAA configuration, its application to catalytic silicon nanowire (SiNW) channels, known for facile low-temperature fabrication and high yield, has faced challenges primarily due to issues with precise positioning and alignment. In exploring this promising avenue, we employed an in-plane solid-liquid-solid (IPSLS) growth technique to batch-fabricate orderly arrays of ultrathin SiNWs, with diameters of D = 22.

Electrostatically Enhanced Biomimetic Asymmetric Hydrogel with a Dung Beetle-Inspired Pattern for Internal Trauma Sealing.

Herein, a biologically asymmetric adhesion-patterned hydrogel induced by the dung beetle surface was proposed for internal trauma sealing. The electrostatic interaction-enhanced dual networks endowed the hydrogel patch with superior mechanical performance, thus achieving a favorable sealing ability. Poly(acrylic acid) (AA), chitooligosaccharide (COS), and gelatin were used as the composition of our hydrogel system.

Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei.

Introduction: Pseudomyxoma Peritonei (PMP) is an extremely rare disease characterized by progressive accumulation of mucinous ascites and implants in the peritoneum. We investigated the prognostic value for response to cytoreductive surgery (CRS) or hyperthermic intraperitoneal chemotherapy (HIPEC) and dissected potential beneficial targeted therapy utilizing genomic characteristics.

Methods: Whole-exome sequencing (WES) was performed on tissue specimens and matched white blood cells from 81 patients with PMP.

Internal hydrodynamics within the skeleton of coral.

Many marine life forms, like coral, develop abiotic components to host and support the growth of living organisms. Using numerical models based on real coral samples reconstructed from micro-computed tomography (CT) scan images, we simulated internal flows inside the skeletons of coral under the influence of ambient ocean currents. The results showed that the coral's skeletal structure, with specially connected pore space, leads to the flow and material transport within and through the skeleton to assist the coral growth and stability.

The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection.

Background & Aims: Dual-phenotype hepatocellular carcinoma (DPHCC) is discernible from classical HCC (CHCC) in its morphology and is characterized by the co-expression of both CHCC and cholangiocyte markers. This study aimed to clarify the difference between DPHCC and CHCC after surgery.

Methods: Patients with HCC after surgery were collected.

Establishment of pupal color as a screening marker and activity analysis of six U6 promoters in Zeugodacus cucurbitae using the white pupae gene.

Background: The genetic control method, which is environmentally friendly and species-specific, has effectively reduced or eliminated pests in many areas. One essential requirement to control a species is the identification of its genetic and molecular elements. Such elements, however, are rarely available in Zeugodacus cucurbitae, a very destructive insect pest worldwide.

Enhanced metals precipitation in acid mine drainage by thermal activation magnesite-pine shavings dispersed alkaline substrate.

The acid mine drainage (AMD) is characterized by its highly acidic nature and elevated concentrations of metal ions, thereby exerting significant impacts on both human health and the environment. This study employed a dispersed alkaline substrate (DAS) consisting of thermal activation magnesite and pine shavings for the treatment of AMD. The investigation focused on determining the optimal thermal activation conditions of magnesite, evaluating the effectiveness of the DAS in regulating acidity and removing metal ions from AMD, identifying critical factors influencing treatment efficiency, and conducting toxicity assessment on the effluent.

Correlation Between Facet Tropism and Ossification of the Posterior Longitudinal Ligament in the Cervical Spine.

Study Design: Retrospective cohort study.

Objectives: To explore the correlation between Facet Tropism (FT) and OPLL in cervical spine.

Methods: One-hundred patients with OPLL of cervical spine and one-hundred normal participants without OPLL or cervical disc herniation were included in this study, the patients were matched to the normal participants respectively based on the same sex and similar age (±5).

Step-necking growth of silicon nanowire channels for high performance field effect transistors.

Ultrathin silicon nanowires (diameter <30 nm) with strong electrostatic control are ideal quasi-1D channel materials for high-performance field effect transistors, while a short channel is desirable to enhance driving current. Typically, the patterning of such delicate channels relies on high-precision lithography, which is not applicable for large area electronics. In this work, we demonstrate that ultrathin and short silicon nanowires channels can be created through a local-curvature-modulated catalytic growth, where a planar silicon nanowires is directed to jump over a crossing step.

Molecular dynamics simulation of film water thickness and properties at different interfaces in partially saturated frozen soil systems.

The film water, with an exceptional capacity to maintain a premelting, liquid-like state even under subzero conditions, provides a potential dynamic conduit for the movement of water in frozen soils. However, the distinctive structural and dynamic characteristics of film water have not been comprehensively elucidated. In this study, molecular dynamics (MD) simulations were conducted to examine the freezing of a system containing ice, water, silica, and gas.

Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis.

Oxidative stress plays a critical role in postmenopausal osteoporosis, yet its impact on osteoblasts remains underexplored, limiting therapeutic advances. Our study identifies phospholipid peroxidation in osteoblasts as a key feature of postmenopausal osteoporosis. Estrogen regulates the transcription of glutathione peroxidase 4 (GPX4), an enzyme crucial for reducing phospholipid peroxides in osteoblasts.

Novel Insights Into Peptide-Calcium Chelates From : Preparation and Its Structure, Stability, and Calcium Transport Analysis.

Peptide-Ca chelates are innovative calcium supplements. possesses nutritional advantages for preparing calcium-binding peptides (CBPs), although there are limited studies on this subject. Therefore, this paper investigated the optimal condition for preparing CBPs and peptide-calcium chelates (LP-Ca), along with analyzing their microstructure, calcium-binding mechanisms, stability, and calcium transporting efficacy.

Clinical Characteristics and Risk Factors of Patients with Lung Cancer Complicated with Pulmonary Embolism: A Case Control Study.

Purpose: The purpose of this study was to investigate the clinical characteristics and risk factors for patients with lung cancer complicated by pulmonary embolism and to provide a reference for the early clinical identification of these patients.

Methods: Eighty patients with lung cancer complicated with pulmonary embolism who were treated at Bethune Hospital of Shanxi from October 2018 to October 2025 were compared with 80 patients with lung cancer without pulmonary embolism. The clinical data of the two groups of patients were collected and analysed.

Metal- and Light-Free Decarboxylative Giese Addition Reaction Facilitated by Hantzsch Ester.

We have developed a novel strategy for decarboxylative radical addition reactions that employs ground-state reduced nicotinamide adenine dinucleotide (NADH) analogues under ambient and open-air conditions, facilitating the efficient formation of Csp-Csp bonds in a variety of substrates. This protocol is distinguished by its operational simplicity, mild reaction conditions, high efficiency, and the use of cost-effective starting materials. Furthermore, experimental studies have provided valuable insights into the reaction mechanism, elucidating the light-independent pathways that promote these transformations.

A STING agonist prodrug reprograms tumor-associated macrophage to boost colorectal cancer immunotherapy.

Tumor-associated macrophages (TAMs) are abundant in colorectal cancer (CRC), correlating with immunosuppression and disease progression. Activation of the stimulator of interferon gene (STING) signaling pathway in TAMs offers a promising approach for CRC therapy. However, current STING agonists face challenges related to tumor specificity and administration routes.

Distinct microbes, metabolites, and the host genome define the multi-omics profiles in right-sided and left-sided colon cancer.

Background: Studies have reported clinical heterogeneity between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). However, none of these studies used multi-omics analysis combining genetic regulation, microbiota, and metabolites to explain the site-specific difference.

Methods: Here, 494 participants from a 16S rRNA gene sequencing cohort (50 RCC, 114 LCC, and 100 healthy controls) and a multi-omics cohort (63 RCC, 79 LCC, and 88 healthy controls) were analyzed.

Combined inflammation-related biomarkers and clinicopathological features for the prognosis of stage II/III colorectal cancer by machine learning.

Background: Inflammation-related biomarkers, such as systemic inflammation score (SIS) and neutrophil-lymphocyte ratio (NLR), are associated with colorectal cancer prognosis. However, the combined role of SIS, NLR, and clinicopathological factors in stage II/III colorectal cancer remains unclear. This study developed a nomogram to predict long-term prognosis for these patients.