Nanocapsuled Neutrophil Extracellular Trap Scavenger Combating Chronic Infectious Bone Destruction Diseases.

Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the bone loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative.

Informing Risk Hotspots and Critical Mitigations for Rainstorms Using Machine Learning: Evidence from 268 Chinese Cities.

Climate change is exacerbating rainstorms, increasing the risk of flooding and threatening urban sustainability, which could undermine climate action. Here, we propose a machine learning-based framework to assess heterogeneous risks and identify critical mitigation measures for rainstorms across 268 Chinese cities. Nighttime light serves as a proxy for urban functionality, and meteorological, socio-economic, and infrastructural factors are incorporated to uncover underlying impact mechanisms.

Identification of phenols and their formation network during the brewing process of Shanxi aged vinegar.

Phenols are important functional compounds present in vineagr, however, their composition and formation pathways remain uncertain. Herein, non-targeted metabolomics and macrotranscriptomics methods were applied to identify phenols and analyze their formation network during the brewing process of Shanxi aged vinegar. A total of 82 phenols were detected from the raw material and the brewing process.

In Vitro Experiment Present ROCK2 Inhibition Promotes the Therapeutic Effect of Bevacizumab in the Treatment of Glioblastoma Multiforme.

Objective: Gliomas are a general designation for neuroepithelial tumors derived from the glial cells of the central nervous system. According to the histopathological and immunohistochemical features, the World Health Organization classifies gliomas into four grades. Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor that has been approved for the treatment of glioblastoma multiforme (GBM) as a second-line therapy.

Relationships Among Physician Vendor-Derived Proficiency Score, Gender, and Time in the Electronic Health Record.

Background And Objectives: Electronic health record (EHR) customization is proposed to mitigate EHR-related burnout. Gender disparities in EHR usage are established, though less is known regarding differences in customization and its impact on EHR time. This study examined gender differences in vendor-derived proficiency score (PS) and its relationship to EHR time.

Salidroside: An Overview of Its Promising Potential and Diverse Applications.

Salidroside, a phenolic compound isolated from various plants, is the principal active constituent of Traditional Chinese Medicine known for its adaptogenic properties. Due to the challenging environment of species, such as high altitude, high radiation, drought, and hypoxia, the source of salidroside is scarce. However, numerous studies have shown that salidroside has a range of biological activities, including cardiovascular and central nervous system activity, and anti-hypoxia, anti-inflammatory, and anti-aging activities.

Electronic structure formed by YO-doping in lithium position assists improvement of charging-voltage for high-nickel cathodes.

High-capacity power battery can be attained through the elevation of the cut-off voltage for LiNiCoMnO high-nickel material. Nevertheless, unstable lattice oxygen would be released during the lithium deep extraction. To solve the above issues, the electronic structure is reconstructed by substituting Li ions with Y ions.

Symmetry Engineering in a 2D Transition Metal Enables Reconfigurable P- and N-Type FETs.

Two-dimensional (2D) transition metals enable the elimination of metal-induced gap states and Fermi-level pinning in field-effect transistors (FETs), offering an advantage over conventional metal contacts. However, transition metal substrates typically exhibit nonoriented behaviors, leading to the inability to achieve monolingual responses with P- or N-type semiconductors. Here we devise symmetry engineering in an oxidized architectural MXene, termed OXene, which implements the exploiting and coupling of additional out-of-plane electron conduction and built-in polar structures.

Mpox Recrudescence after SARS-CoV-2 Coinfection in a Patient with AIDS.

People living with HIV (PLWH) are known to exhibit more severe or prolonged symptoms of mpox (formerly monkeypox). However, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PLWH with mpox has not been adequately described. We report a case of mpox in an AIDS patient who had recurrent symptoms due to SARS-CoV-2 infection.

Multi-Functional Bio-HJzyme Engineered Polyetheretherketone Implant with Cascade-Amplification Therapeutic Capabilities Toward Intractable Implant-Associated Infections.

Intractable implant-associated infections (IAIs) are the primary cause of prosthetic implant failure, particularly in the context of diabetes mellitus. There is an urgent need to design and construct versatile engineered implants integrated with cascade amplification therapeutic modality to significantly improve the treatment of diabetic IAIs. To address this issue, a multi-functional MXene/AgPO@glucose oxidase bio-heterojunction enzyme (M/A@GOx bio-HJzyme) coating is developed, which is decorated with an inert sulfonated polyetheretherketone implant (SP-M/A@G) via hydrothermal treatment and layered deposition.

Predictive biosignatures for hospitalization in patients with virologically confirmed COVID-19.

Background: COVID-19, caused by the SARS-CoV-2 virus, presents with varying severity among individuals. Both viral and host factors can influence the severity of acute and chronic COVID-19, with chronic COVID-19 commonly referred to as long COVID. SARS-CoV-2 infection can be properly diagnosed by performing real-time reverse transcription PCR analysis of nasal swab samples.

Regenerative Biomimetic Photosynthesis by Covalent-Organic Framework-Based Nanobiohybrids.

Biomimetic photosynthesis, which leverages nanomaterials with light-responsive capabilities, represents an innovative approach for replicating natural photosynthetic processes for green and sustainable energy conversion. In this study, a covalent-organic framework (COF)-based artificial photosynthesis system is realized through the co-assembly of adenosine triphosphate (ATP) synthase and a light-responsive proton generator onto an imine-based COF, RT-COF-1. This system demonstrates an ATP production rate of 0.

Single-cell transcriptomes of dissecting the intra-tumoral heterogeneity of breast cancer microenvironment.

Objective: To investigate the mechanism by which heterogeneity in breast cancer developed and acted in single-cell transcriptomes.

Methods: The composition of breast cancer based on the single-cell transcriptomes of 54,055 high-quality cells from clinical specimens of 4 malignant and 4 non-malignant patients were investigated.

Results: We identified six common expression programs and six subtype-specific expression programs form malignant epithelial cells.

[Remediation Effect of Iron-manganese Composite-modified Biochar from Different Biomasses on Cd-contaminated Alkaline Soil].

To investigate the remediation effect of iron-manganese-modified biochar from different biomasses （FM-BC） on Cd-contaminated alkaline soil, FM-BC was prepared using branches of , durian shells, and corn stalks. The characteristics of FM-BC, the adsorption of Cd（Ⅱ） in water, and the available, fraction of Cd in alkaline soil were studied using bath adsorption and soil culture experiments. The results showed that the specific surface area, total pore volume, and oxygen content of FM-BC were significantly improved.

Combining stable isotopes and multi-elements with machine learning chemometric models to identify the geographical origins of Tetrastigma hemsleyanum Diels et Gilg.

Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is an edible plant with considerable medicinal properties, the quality of which varies depending on its origin. Therefore economically motivated adulteration has emerged.

Physiological and transcriptomic analysis of purple flowering stalks (Brassica campestris var. purpurea) under cadmium stress and exogenous glutathione application.

Glutathione (GSH) has a beneficial effect on the response of plants to cadmium (Cd) stress. The physiological and molecular processes by which glutathione influences Cd tolerance in purple flowering stalks (a Brassica vegetable) remain unclear. The aim of this study was to investigate the role of exogenous GSH in alleviating Cd toxicity in purple flowering stalks.

Sex Differences in Basal Cortisol Levels Across Body Fluid Compartments in a Cross-sectional Study of Healthy Adults.

Context: Many studies have moved toward saliva and peripheral blood sampling for studying cortisol, even in relation to disorders of the brain. However, the degree to which peripheral cortisol reflects central cortisol levels has yet to be comprehensively described. Data describing the effect that biological characteristics such as age and sex have on cortisol levels across compartments is also limited.

Supergrowth in speckle patterns.

Supergrowth occurs when the local amplitude growth rate of a wave is greater than that predicted by the band limit. While generating supergrowth on demand requires precise source modulation, we demonstrate that supergrowth occurs naturally in a sum of random plane waves. We measure the supergrowing fractional area of transverse, monochromatic, fully developed speckle patterns.

Sheets Copper-Cobalt Graphitic Carbon Nitride Dual Single-Atom Catalysts for the Epoxidation of Styrene.

Dual single-atom catalysts have attracted considerable research interest due to their higher metal atom loading and more flexible active sites compared to single-atom catalysts (SACs). We pioneered the one-step synthesis of sheets copper-cobalt graphitic carbon nitride dual single-atom (S-Cu/Co-g-C3N4) using folding fan-shaped aluminum foil as a template, and used them as catalysts in the epoxidation of styrene respectively. Through XAFS（X-ray Absorption Fine Structure） and other characterizations, it is found that Cu and Co single atoms are stabilized separately on g-C3N4 via coordination with nitrogen (N), hindered the ordered growth of sheets, and formed more pore structures, which not only increased more catalytically active sites, but also effectively prevented the flakes re-aggregate during the catalytic process.

Crystal structure of [Ni(OH)]Cl·(18-crown-6)·2HO.

The crystal structure of the title compound, hexa-aqua-nickel(II) dichloride-1,4,7,10,13,16-hexa-oxa-cyclo-octa-deca-ne-water (1/2/2), [Ni(HO)]Cl·2CHO·2HO, is reported. The asymmetric unit contains half of the Ni(OH) moiety with a formula of CHClNiO at 105 K and triclinic (1) symmetry. The [Ni(OH)] cation has close to ideal octa-hedral geometry with O-Ni-O bond angles that are within 3° of idealized values.

Two-Dimensional MXenes: Innovative Materials for Efficient Thermal Management and Safety Solutions.

MXenes, a class of 2-dimensional transition metal carbides and nitrides, have garnered important attention due to their remarkable electrical and thermal conductivity, high photothermal conversion efficiency, and multifunctionality. This review explores the potential of MXene materials in various thermal applications, including thermal energy storage, heat dissipation in electronic devices, and the mitigation of electromagnetic interference in wearable technologies. Recent advancements in MXene composites, such as MXene/bacterial cellulose aerogel films and MXene/polymer composites, have demonstrated enhanced performance in phase change thermal storage and electromagnetic interference shielding, underscoring their versatility and effectiveness.

Interaction between sex and one-hour post-load glucose on metabolic syndrome and its components among Chinese people at high risk of diabetes.

Background: Recently, International Diabetes Federation position statement has adopted one-hour post-load glucose (1hPG) ≥ 8.6 mmol/L for diagnosing intermediate hyperglycemia. We aimed to assess the association of 1hPG ≥ 8.

Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.

Ovarian dysfunction caused by aging restricts female reproductive capacity and is accompanied by oxidative stress and impaired autophagy. Recent studies have shown that trehalose (Tre) can activate autophagy and have antioxidant effects. However, whether Tre can be used to attenuate ovarian aging remains unclear.

Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation.

Cooperative interactions profoundly shape individual and collective behaviors of social animals. Successful cooperation requires coordinated efforts by cooperators toward collective goals. However, the underlying behavioral dynamics and neuronal mechanisms within and between cooperating brains remain largely unknown.

Comparation of pheromone-binding proteins 1 and 2 of Spodoptera frugiperda in perceiving the three sex pheromone components Z9-14:Ac, Z7-12: Ac and Z11-16: Ac.

Pheromone-binding proteins (PBPs) are mainly responsible for binding and transporting hydrophobic pheromone molecules across the aqueous sensilla lymph to the receptor proteins. The preference of each PBP is believed to be different for each pheromone component within a single species. Significantly higher expression level of PBP1 and PBP2 in the male antennae of Spodoptera frugiperda suggesting that SfruPBP1 and SfruPBP2 might play important roles in pheromone perception.