Publications by authors named "Liang Jun Zhang"
The segmentation of blood vessels from retinal images is an important and challenging task in medical analysis and diagnosis. This paper proposes a new architecture of the U-Net network for retinal blood vessel segmentation. Adding dense block to U-Net network makes each layer's input come from the all previous layer's output which improves the segmentation accuracy of small blood vessels.
View Article and Find Full Text PDFAngiopoietin-like protein 2 (ANGPTL2), a member of the glycoprotein family, is mainly secreted by adipose tissues under normal conditions. Recently, ANGPTL2 has been found to be upregulated in some types of cancers and is considered to be a tumor promoter. However, the functional significance of ANGPTL2 in glioma has not yet been elucidated.
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- MRP2 is crucial for bile acid metabolism as it transports toxic substances, but its expression is reduced in cholestatic conditions, although the reasons for this are not fully understood.
- In a study using HepG2 cells, researchers found that interleukin-18 (IL-18) decreased MRP2 expression in a dose and time-dependent manner, which was linked to the activation of the NF-κB pathway that upregulates YY1 and downregulates FXR.
- Further analysis revealed that in bile duct-ligated rats, there was increased expression of IL-18 and NF-κB with decreased levels of FXR and MRP2, suggesting that IL-18's effects
[Genetic Polymorphisms in Wnt Signaling Pathway and Acute Leukemia].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2015
Article Synopsis
- The study aimed to assess how specific gene polymorphisms in the Wnt signaling pathway affect the risk and treatment outcomes of acute leukemia, focusing on three specific SNPs in the CTNNB1, AXIN2, and SFRP1 genes.
- Bone marrow and blood samples from leukemia patients and healthy controls were analyzed using high-resolution melting methods, with statistical tests performed to compare genetic variations and their associations with clinical features and chemotherapy outcomes.
- Results indicated no significant genetic differences for CTNNB1 and SFRP1 between patients and controls, but the AXIN2 variant affected leukemia type and patient outcomes, with A allele carriers showing better clinical results, including higher platelet counts and remission rates after treatment.
Bis(3,5-dimethyl-1H-pyrazole-κN)(pyridine-2,6-dicarboxyl-ato-κO,N,O)copper(II).
Acta Crystallogr Sect E Struct Rep Online
February 2009
In the crystal structure of the title compound, [Cu(C(7)H(3)NO(4))(C(5)H(8)N(2))(2)], the Cu(II) cation assumes a distorted trigonal-bipyramidal coordination geometry formed by a pyridine-2,6-dicarboxyl-ate dianion and two 3,5-dimethyl-1H-pyrazole mol-ecules. N-H⋯O hydrogen bonding is present in the crystal structure.
View Article and Find Full Text PDFTetra-aqua-(2,2'-diamino-4,4'-bi-1,3-thia-zole-κN,N)nickel(II) bis-(pyridine-2,6-dicarboxyl-ato-κO,N,O)nickel(II) trihydrate.
Acta Crystallogr Sect E Struct Rep Online
February 2009
The crystal structure of the title compound, [Ni(C(6)H(6)N(4)S(2))(H(2)O)(4)][Ni(C(7)H(3)NO(4))(2)]·3H(2)O, consists of Ni(II) complex cations, Ni(II) complex anions and lattice water mol-ecules. The Ni(II) ions in both the complex cation and anion assume a distorted octa-hedral coordination geometry. O-H⋯O, N-H⋯O and C-H⋯S hydrogen bonds occur in the crystal structure.
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