MRI-based multiregional radiomics for desmoplastic reaction classification and prognosis stratification in stage II rectal cancer: A bicenter study.

Purpose: To develop an MRI-based multiregional radiomics model for the noninvasive desmoplastic reaction (DR) classification and prognosis stratification in stage II rectal cancer (RC) patients.

Materials And Methods: This study retrospectively involved 336 patients with RC from two centers, with 239 from Center 1 divided into training (n = 191) and internal validation (n = 48) datasets at an 8:2 ratio, and 97 from Center 2 serving as external validation dataset. Radiomics features were extracted, and a multiregional radiomics DR (M-RDR) signature was established using multi-level feature selection procedure.

[Sulforaphane alleviates acute liver injury induced by diquat in mice by activating Keap1/Nrf2 signaling pathway].

Objective: To investigate the protective effect and possible mechanism of sulforaphane (SFN) on acute liver injury in mice induced by diquat (DQ) poisoning.

Methods: Forty-eight male C57BL/6 mice were divided into Control group, DQ model group (DQ group), SFN intervention group (DQ+SFN group), and SFN control group (SFN group) using a random number table method, with 12 mice in each group. Acute liver injury mice model was established by one-time intraperitoneal injection of 1 mL of 40 mg/kg DQ solution at once.

Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective cohort study.

Background: Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) higher than 5. However, these findings are not confirmed in real-world settings, and the benefits in PD-L1 CPS < 5 patients remain controversial.

Methods: In this multicenter, retrospective cohort study, data from across thirteen medical centers were analyzed by inverse probability of treatment weighting for matching, alongside univariate and multivariate COX proportional hazard regression models.

Comparing the protection of heterologous booster of inhaled Ad5-nCoV vaccine and hybrid immunity against Omicron BA.5 infection: a cohort study of hospital staff in China.

Background: After the exit "zero-COVID" strategy in mainland China by the end of 2022, a large-scale COVID-19 outbreak seeded by Omicron variants occurred. An inhaled adenovirus type-5 vector-based (i.e.

Optimization of pharmacy membership management system based on big data: Sleeping member activation and awakening methods using ANN modeling.

In the retail industry, effective management of memberships is crucial, particularly within the pharmaceutical sector, as it fosters customer loyalty and drives sales growth. However, pharmacies often face challenges related to membership attrition and inactive members, which restrict the full potential of their membership programs. This research aims to address these challenges by optimizing pharmacy membership management systems through the utilization of big data technology.

Fully Printable Manufacturing of Miniaturized, Highly Integrated, Flexible Evaporation-Driven Electricity Generator Arrays.

Harvesting sustainable clean energy from natural water evaporation holds great promise to provide continuous power for portable and wearable electronics. However, poor portability and complex fabrication processes hinder the low-cost and large-scale integration of flexible evaporation-driven electricity generators (FEEGs). Herein, a fully-printed flexible evaporation-driven generator (PFEEG) is developed.

Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono-Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma.

Immune checkpoint blockade (ICB) is combined with sonodynamic therapy (SDT) to increase response rates and enhance anticancer efficacy. However, the "always on" property of most sonosensitizers in reducing tumor microenvironment (TME) compromises the therapeutic outcome of sonoimmunotherapy and exacerbates adverse side effects. Precisely controllable strategies combining sulfur dioxide (SO) gas therapy with cancer immunotherapy can address these issues but remain lacking.

Immunological characteristics in elderly COVID-19 patients: a post-COVID era analysis.

Background: Advanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. In the post-pandemic era, with containment measures lifted, the elderly remain particularly susceptible, highlighting the need for intensified focus on immune health management.

Methods: A total of 281 elderly patients were enrolled in this study and categorized based on their clinical status at the time of admission into three groups: non-severe (n = 212), severe survivors (n = 49), and severe non-survivors (n = 20).

Gonadal hormone abnormalities in young patients with first-episode schizophrenia.

Background: Gonadal hormones have been reported to be involved in the molecular mechanisms of schizophrenia (SCH). However, only a few studies have examined the gonadal hormone dysfunctions in first-episode schizophrenia (FES) patients, in particular in young patients with SCH. This study was designed to investigate the sex differences in gonadal hormones in young and antipsychotic-naïve FES patients.

Nanozymes featuring a mesoporous silica shell for rapid enrichment and ultrasensitive lateral flow immunoassay of influenza A.

Background: Respiratory illnesses stemming from influenza A viruses represent a significant worldwide health concern. There is an immediate need for a rapid and sensitive method to detect influenza A viruses early, without requiring extra equipment.

Results: Here, we established a lateral flow immunoassay (LFIA) for the detection of influenza A (Flu A) using a "three-in-one" multifunctional mesoporous FeO@SiO@Pt nanozymes (FeO@MSiO@Pt NZs) with excellent magnetic separation properties, colorimetric, and peroxidase-like (POD-like) activities.

Palladium-Catalyzed Coupling of Aryl Chlorides with Secondary Phosphines to Construct Unsymmetrical Tertiary Phosphines.

The functionalization of the C-Cl bond in unactivated aryl chlorides under mild conditions presents a significant challenge. We disclose a general protocol for constructing both partially and entirely unsymmetrical tertiary phosphines through the Pd/keYPhos-catalyzed coupling of aryl chlorides with secondary phosphines under mild conditions. The reaction exhibits excellent functional group tolerance and broad substrate scopes.

Reverse engineering of Onivyde® - Irinotecan liposome injection.

Onivyde® is an intravenous irinotecan liposomal injection approved by the FDA for the treatment of gemcitabine-refractory metastatic adenocarcinoma of the pancreas in combination with fluorouracil and leucovorin. In the Onivyde® formulation, irinotecan is encapsulated in the inner compartment of the liposome using sucrose octasulfate as a trapping agent, and stabilized by a pegylated lipid membrane, resulting in prolonged circulation in the body. Due to its complex formulation design, there is limited information available regarding the critical quality attributes (CQAs) of Onivyde® and suitable methods for evaluating these attributes.

Distributional uniformity quantification in heterogeneous prepared dishes combined the hyperspectral imaging technology with Moran's I: A case study of pizza.

Quality detection is critical in the development of prepared dishes, with distributional uniformity playing a significant role. This study used hyperspectral imaging (HSI) and Moran's I to quantify distributional uniformity, employing pizza as case. Pizza ingredients' spectra were collected, pre-processed with Detrended Fluctuation Analysis (DFA), Savitzky-Golay (SG) and Standard Normal Variate (SNV), and down-scaled with Principal Component Analysis (PCA).

Novel insight into deriving remediation goals of arsenic contaminated sites with multi-media-equivalent dose and local exposure parameters.

The remediation goal (RG) for arsenic (As) calculated by the traditional method is approximately 0.45 mg·kg, significantly lower than the background values. This poses significant challenges for the management of As-contaminated sites.

Interfacial Effects of NiFe-Based Bifunctional Electrocatalysts for Highly Efficient Overall Water Splitting.

The reasonable design of highly efficient NiFe-based bifunctional electrocatalysts is imperative for water splitting and alleviation of the energy crisis. Herein, the NiFe-based bifunctional electrocatalysts are designed and grown in situ on Ni foam by a simple hydrothermal method. The interfacial effect among NiFe-LDH, FeO(OH), and NiFeO exposes more catalytic active sites, modulated electronic structure, and optimization of the electrocatalytic performances.

Development of a prognostic model for early-stage gastric cancer-related DNA methylation-driven genes and analysis of immune landscape.

Background And Aims: This study aimed to develop a prognostic model based on DNA methylation-driven genes for patients with early-stage gastric cancer and to examine immune infiltration and function across varying risk levels.

Methods: We analyzed data from stage I/II gastric cancer patients in The Cancer Genome Atlas which included clinical details, mRNA expression profiles, and level 3 DNA methylation array data. Using the empirical Bayes method of the limma package, we identified differentially expressed genes (DEGs), and the MethylMix package facilitated the identification of DNA methylation-driven genes (DMGs).

Comparing the in-hospital outcomes of patients with Takotsubo cardiomyopathy and chronic obstructive pulmonary disease.

Background: Secondary Takotsubo syndrome (TTS) differs from primary TTS in terms of clinical characteristics, management, and prognosis. COPD exacerbation has been recognized as a physical trigger for TTS, but its prognostic implications for secondary TTS are poorly understood.

Objectives: The purpose of this study was to examine the effects of COPD on in-hospital outcomes in TTS patients.

CRISPR/Cas13a Trans-Cleavage and Catalytic Hairpin Assembly Cascaded Signal Amplification Powered SERS Aptasensor for Ultrasensitive Detection of Gastric Cancer-Derived Exosomes.

Cancer-derived exosomes carry a large number of specific molecular profiles from cancer cells and have emerged as ideal biomarkers for early cancer diagnosis. Accurate detection of ultralow-abundance exosomes in complex biological samples remains a great challenge. Herein, a novel SERS aptasensor powered by cascaded signal amplification of CRISPR/Cas13a -cleavage and catalytic hairpin assembly (CHA) was proposed for ultrasensitive detection of gastric cancer-derived exosomes, which included hairpin-structured recognition aptamers (MUC1-apt), cascaded signal amplification (i.

Nanofiltration Membrane with Enhanced Ion Selectivity Based on a Precision-Engineered Ultrathin Polyethylene Supporting Layer.

Nanofiltration (NF) technology is increasingly used in the water treatment and separation fields. However, most research has focused on refining the selective layer while overlooking the potential role of the supporting layer. With expertise in ultrathin polymer films, particularly in the production of polyethylene (PE) membranes, we explore the possibility of improving NF membrane performance by precisely controlling the structure and surface properties of the ultrathin supporting layer in this work.

Spectral CT-based nomogram for preoperative prediction of Lauren classification in locally advanced gastric cancer: a prospective study.

Objectives: To develop a nomogram based on clinical features and spectral quantitative parameters to preoperatively predict the Lauren classification for locally advanced gastric cancer (LAGC).

Methods: Patients diagnosed with LAGC by postoperative pathology who underwent abdominal triple-phase enhanced spectral computed tomography (CT) were prospectively enrolled in this study between June 2023 and December 2023. All the patients were categorized into intestinal- and diffuse-type groups according to the Lauren classification.

Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer.

PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer; however, only a minority of colorectal cancer (CRC) patients benefit from these treatments. The efficacy of PD-1/PD-L1 blockade in CRC is limited by the complexities of tumor microenvironment. PD-1/PD-L1 blockade immunotherapy is based on T cell-centered view of tumor immunity.