Role of the NOD1/Rip2 Signaling Pathway in Macrophage Inflammatory Activation Induced by ox-LDL.

This study aimed to investigate the impact of the NOD1/Rip2 signaling pathway on macrophage inflammatory activation and polarity switching in ox-LDL-induced THP-1-derived macrophages. THP-1-derived macrophages were stimulated with various concentrations (10, 25, or 50 mg/L) of ox-LDL for different durations (8, 16, or 24 h). Quantitative real-time PCR was used to measure the mRNA expression of NOD1, Rip2, IL-10, IL-12, iNOS, and Arg-1.

Design, synthesis and biological evaluation of novel benzimidazole-derived p21-activited kinase 4 (PAK4) inhibitors bearing a 4-(4-methylpiperazin-1-yl)phenyl scaffold as potential antitumor agents.

A series of novel 6-(4-(4-methylpiperazin-1-yl)phenyl)-1H-benzo[d]imidazole-based p21-activited kinase 4 (PAK4) inhibitors were designed and synthesized based on the structure of lead compound GNE-2861 and that of anticancer inhibitors reported in our previous studies. All target compounds so designed were preliminarily screened in vitro for anti-tumor potency through kinase inhibitory assays and MTT assays, which revealed that most compounds exhibited significant inhibitory effects on PAK4 enzyme as well as prominent antiproliferative activities against four cancer cell models (A549, NCI-H1975, MDA-MB-231 and SK-BR-3) and low damage to healthy cells. In particular, the hit compound 12i was identified as the most effective and rather selective compound both at the enzyme and cellular level.

Genomic Insights into the Role of TOP Gene Family in Soft-Tissue Sarcomas: Implications for Prognosis and Therapy.

This study focuses on the role of topoisomerases (TOPs) in sarcomas (SARCs), highlighting TOPs' influence on sarcoma prognosis through mRNA expression, genetic mutations, immune infiltration, and DNA methylation analysis using transcriptase sequencing and other techniques. The findings indicate that TOP gene mutations correlate with increased inflammation, immune cell infiltration, DNA repair abnormalities, and mitochondrial fusion genes alterations, all of which negatively affect sarcoma prognosis. Abnormal TOP expression may independently affect sarcoma patients' survival.

Current spectral norm and phase variation based fault region identification for active distribution network.

The paper presents a fault region identification method for the active distribution network (ADN) with limited PMU. First, PMU configuration and region division strategies are proposed based on the network topology. Next, the difference in three-phase current variations between the normal and fault regions of the ADN is analyzed.

Corrosion Monitoring by Plastic Optic Fiber Sensor Using Bi-Directional Light Transmission.

In this paper, a new sensor is proposed to efficiently gather crucial information on corrosion phenomena and their progression within steel components. Fabricated with plastic optical fibers (POF), the sensor can detect corrosion-induced physical changes in the appearance of monitoring points within the steel material. Additionally, the new sensor incorporates an innovative structure that efficiently utilizes bi-directional optical transmission in the POF, simplifying the installation procedure and reducing the total cost of the POF cables by as much as 50% when monitoring multiple points.

Experimental Investigation for Monitoring Corrosion Using Plastic Optical Fiber Sensors.

The timely and cost-effective identification of the onset of corrosion and its progress would be critical for effectively maintaining structural integrity. Consequently, a series of fundamental experiments were conducted to capture the corrosion process on a steel plate using a new type of plastic optical fiber (POF) sensor. Electrolytic corrosion experiments were performed on a 5 mm thick steel plate immersed in an aqueous solution.

The effect of novel aquaculture mode on phosphorus sorption-release in pond sediment.

The emergence of aquaculture modes has brought considerable changes to the aquaculture landscape and profoundly influenced environmental processes. However, there is limited research on nutrient cycling in emerging aquaculture modes. This study investigated the characteristics and mechanisms of sediment phosphorus (P) sorption-release in traditional earthen pond culture (TEP) and pond-tank culture mode (PTC), which represents novel aquaculture modes.

Comparison of sound touch elastography and quantification for assessing the renal pathologic changes in patients with proteinuria.

Objective: Sound touch elastography (STE) and sound touch quantification (STQ) are novel imaging methods to evaluate tissue stiffness. This study aims to investigate renal stiffness in patients with chronic kidney disease (CKD) by STE and STQ, using renal biopsy as 'gold standard'.

Methods: Between 2019 January and 2022 June, 60 patients who underwent renal biopsy for proteinuria (cases) and 45 healthy volunteers (controls) at our hospital were included in this study.

Sulfasalazine inhibits esophageal cancer cell proliferation by mediating ferroptosis.

This study aimed to explore the potential mechanism by which sulfasalazine (SAS) inhibits esophageal cancer cell proliferation. A cell counting kit-8 (CCK-8) assay was used to detect the effect of SAS (0, 1, 2, and 4 mM) on the proliferation of TE-1 cells. Subsequently, TE-1 cells were divided into control group, SAS group, SAS + ferrostatin-1 (ferroptosis inhibitor) group, and SAS + Z-VAD (OH)-FMK (apoptosis inhibitor) group, and cell proliferation was measured using a CCK-8 assay.

Fractal Analysis of Fuel Nozzle Surface Morphology Based on the 3D-Sandbox Method.

The dual oil circuit centrifugal fuel nozzle is made of martensitic stainless steel, which has complex morphological characteristics. The surface roughness characteristics of the fuel nozzle directly affect the degree of fuel atomization and the spray cone angle. The surface characterization of the fuel nozzle is investigated by the fractal analysis method.

Deformation prediction of functionally graded materials in laser directional energy deposition using forward-inverse calibration of the inherent strain in multi-scanning directions.

This paper presents the study of the residual deformation of functional gradient materials (FGMs) constructed by laser directed energy deposition (L-DED) and proposes a forward and reverse framework for inherent strain calibration, considering the effect of scan directions. First, the inherent strain and the corresponding residual deformation in the scanning strategies with the 0°, 45°, and 90° directions are calculated from the multi-scale model of the forward process, respectively. Then the inherent strain is calibrated inversely using the pattern search method based on the residual deformation of experiments by L-DED.

An Improved Shape from Focus Method for Measurement of Three-Dimensional Features of Fuel Nozzles.

The precise three-dimensional measurement of fuel nozzles is of great significance to assess the manufacturing accuracy and improve the spray and atomization performance. This paper proposes an improved fast shape from focus (SFF) method for three-dimensional measurement of key features of fuel nozzles. In order to ensure the measurement accuracy and efficiency of the SFF, the dispersion of the measured points from a standard flat plane was used to select the optimal combination of the focus measure operator, window size and sampling step size.

From an identity process theory perspective: a daily investigation of why and when ostracism triggers ingratiation.

Although existing studies suggest the relationship between ostracism and ingratiation, the knowledge about why and when ostracism promotes ingratiatory behaviors remains limited. Drawing from identity process theory, the current study examines the influence of ostracism on ingratiatory behaviors through the mediating role of self-identity threat on a daily timescale and the cross-level moderation of core self-evaluation. Through a diary study of 117 Chinese college students across 14 consecutive days, we found that daily ostracism had a positive indirect effect on daily ingratiatory behaviors through daily self-identity threat.

Multi-Object Detection Method in Construction Machinery Swarm Operations Based on the Improved YOLOv4 Model.

To handle the problem of low detection accuracy and missed detection caused by dense detection objects, overlapping, and occlusions in the scenario of complex construction machinery swarm operations, this paper proposes a multi-object detection method based on the improved YOLOv4 model. Firstly, the K-means algorithm is used to initialize the anchor boxes to improve the learning efficiency of the depth features of construction machinery objects. Then, the pooling operation is replaced with dilated convolution to solve the problem that the pooling layer reduces the resolution of feature maps and causes a high missed detection rate.

Modeling and Verification of an Acquisition Strategy for Wheel Loader's Working Trajectories and Resistance.

To overcome the difficulty of collecting the working resistance and working trajectory of a wheel loader, this paper constructs a statics model of the bucket working resistance and a kinematics model of the working trajectory in the shoveling process and analyzes the key parameters of measuring the working resistance and working trajectory. Based on this, a working resistance and working trajectory acquisition strategy is proposed. To verify the effectiveness of the acquisition strategy, the in-service operation data of fine sand and loose soil shoveled by the wheel loader are collected and analyzed.

3D Measurement Method for Saturated Highlight Characteristics on Surface of Fuel Nozzle.

Saturated highlights on metal surfaces reduce the detection accuracy of fuel nozzles. In this paper, we propose an image inpainting method with a saturated highlight based on the statistics of similar patches used in prior segmentation of the subregion. The sequence image acquisition is based on the shape from focus in the five-axis platform.

Correlation between Carotid Stenosis Degree and Blood Pressure Variability in Patients with Carotid Stenosis.

Background: Carotid artery stenosis is one of the most serious diseases that endanger human health in contemporary times. It is a frequently occurring and common disease of the middle-aged and elderly people. Its incidence is increasing year by year, bringing a heavy economic burden to society and families.

Chiro-optical fields with asymmetric orbital angular momentum and polarization.

In this paper, we proposed a flexible method for generating asymmetric chiro-optical fields. Different from most of the chiro-optical fields superimposed by vortex beams which are rotationally symmetric, the asymmetric chiro-optical field has a locally controllable orbital angular momentum (OAM) and polarization state. By using a helix phase plate (HPP) calculated based on coordinates transformation of the perfect vortex, the OAM controllability of a single chiro-optical field could be achieved.

The Idea Is Mine! An Empirical Examination on the Effect of Leaders' Credit Claiming on Employees' Work Outcomes.

Existing studies mainly explored the detrimental effect of employee credit claiming, and little is known about how leader credit claiming can affect employees. Based on affective events theory and relative deprivation theory, we explore how leader credit claiming affects employee work outcomes (i.e.

Linking Identity Leadership and Team Performance: The Role of Group-Based Pride and Leader Political Skill.

Recent trends in the leadership literature have promoted a social identity approach of leadership that views leadership as the process of representing, advancing, creating, and embedding a sense of shared identity within a group. However, a few empirical studies explore how and when global identity leadership affects team performance at the workplace. To address this lacuna, we used multi-source and two-wave data among 81 teams to explore the role of group-based pride and leader political skill in the association between identity leadership and team performance.

Staging Liver Fibrosis: Comparison of Native T1 Mapping, T2 Mapping, and T1ρ: An Experimental Study in Rats With Bile Duct Ligation and Carbon Tetrachloride at 11.7 T MRI.

Background: T1, T2, and T1ρ might be potential biomarkers for assessing liver fibrosis. However, few studies reported the value of them in different animal models.

Purpose: To investigate and compare the performances of T1, T2, and T1ρ for noninvasively staging liver fibrosis in bile duct ligation (BDL) or carbon tetrachloride (CCl ) model.

CT radiomics facilitates more accurate diagnosis of COVID-19 pneumonia: compared with CO-RADS.

Background: Limited data was available for rapid and accurate detection of COVID-19 using CT-based machine learning model. This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia compared with clinical model and COVID-19 reporting and data system (CO-RADS), and develop an open-source diagnostic tool with the constructed radiomics model.

Methods: This study enrolled 115 laboratory-confirmed COVID-19 and 435 non-COVID-19 pneumonia patients (training dataset, n = 379; validation dataset, n = 131; testing dataset, n = 40).

Clinico-Radiological Features and Outcomes in Pregnant Women with COVID-19 Pneumonia Compared with Age-Matched Non-Pregnant Women.

Purpose: To investigate the clinico-radiological findings and outcomes in pregnant women with COVID-19 pneumonia compared to age-matched non-pregnant women.

Methods: A retrospective case-controlled study was conducted to review clinical and CT data of 21 pregnant and 19 age-matched non-pregnant women with COVID-19 pneumonia. Four stages of CT images were analyzed and compared based on the time interval from symptom onset: stage 1 (0-6 days), stage 2 (7-9 days), stage 3 (10-16 days), and stage 4 (>16 days).

Ultrasensitive electrochemical detection of Mycobacterium tuberculosis IS6110 fragment using gold nanoparticles decorated fullerene nanoparticles/nitrogen-doped graphene nanosheet as signal tags.

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains the top fatal infection continuing to threat public health, and the present detection method for MTB is facing great challenges with the global TB burden. In response to this issue, a novel electrochemical DNA biosensor was developed for detecting the IS6110 fragment within MTB. For the first time, the nanohybrid of gold nanoparticles decorated fullerene nanoparticles/nitrogen-doped graphene nanosheet (Au-nano-C/NGS) directly served as a new signal tag to generate signal response without additional redox molecules and subsequently labeled with signal probes (SPs) to form tracer label to achieve signal amplification.