Characteristics of 3D-Integrated GaN Power Module Under Multi Heat Source Coupling.

3D-integrated GaN power modules can effectively reduce parasitic parameters and enhance the power system's performance. However, the heat from each power chip during operation can lead to a mutual thermal coupling effect, potentially causing performance drift of the GaN power chips. This work investigates the impact of the thermal coupling effect in a 3D-integrated GaN power module on the characteristics of its GaN power chips.

Phototherapeutic activity of polypyridyl ruthenium(II) complexes through synergistic action of nitric oxide and singlet oxygen.

In recent years, photodynamic therapy (PDT) and gas therapy (GT) have emerged as research hotspots due to their excellent cancer treatment efficacy. By combining the advantages of both, the simultaneous and controllable release of reactive oxygen species (ROS) and nitric oxide (NO) has become a possibility. This paper describes the design of two Ru(II) complexes, [Ru(bpy)(NFIP)](PF) (Ru1, bpy = 2,2'-bipyridine, NFIP = 4-nitro-3-trifluoromethylaniline-1-imidazo[4,5-][1,10]phenanthroline) and [Ru(phen)(NFIP)](PF) (Ru2, phen = 1,10-phenanthroline), through the integration of the polypyridyl ruthenium structure and a photoresponsive NO donor.

Mapping 1-km soybean yield across China from 2001 to 2020 based on ensemble learning.

Soybean is a critical agricultural product in China, with domestic production unable to satisfy the substantial demand, leading to a huge reliance on imports. To support the scientific formulation of agricultural policies and the optimization of domestic planting structures, we developed a high-resolution annual soybean yield dataset for China (2001-2020), ChinaSoyYield1km. This dataset was generated by applying ensemble learning algorithms and spatial decomposition to a comprehensive set of multi-source data, including climate variables, remote sensing imagery, soil properties, agricultural management practices, and official yield records.

Rational Fabrication of a Robust, Exfoliatable Catechol-Porphyrin Covalent Network for Enhanced HO Photosynthesis.

Covalent organic frameworks (COFs) containing dioxin-linkages are highly valued for their exceptional chemical stability, which is essential for practical use. However, research on dioxin-based COFs remains limited. Herein, a unique nonplanar 2D COF, designated as TCP-COF, constructed from catechol-porphyrin units interconnected by 1,4-dioxin bonds, exhibiting a staggered AAA stacking pattern, is presented.

Fully Field-Free Spin-Orbit Torque Switching Induced by Spin Splitting Effect in Altermagnetic RuO.

Altermagnetism, a newly identified class of magnetism blending characteristics of both ferromagnetism and antiferromagnetism, is emerging as a compelling frontier in spintronics. This study reports a groundbreaking discovery of robust, 100% field-free spin-orbit torque (SOT) switching in a RuO(101)/[Co/Pt]/Ta structure. The experimental results reveal that the spin currents, induced by the in-plane charge current, flow along the [100] axis, with the spin polarization direction aligned parallel to the Néel vector.

Bioavailability, migration and driving factors of As, Cd and Pb in calcareous soil amended with organic fertilizer and manganese oxidizing bacteria in arid northwest China.

Organic matter, serving as a carbon source and energy provider for microbial activities driving manganese oxidation in soil, plays a vital role in the biogeochemical processes underlying the formation of biological manganese oxides (BMOs) and regulating heavy metal (HMs) mobility within soil profiles. The interactions between BMOs and organic matter, their environmental behavior, and practical field applications remain poorly understood. In this study, the remediation effectiveness of organic fertilizer (OF) and manganese-oxidizing bacteria (B) in addressing arsenic (As), cadmium (Cd), and lead (Pb) co-contamination in soil was evaluated, alongside the resulting elemental migration within the soil profile, uptake by maize, and post-remediation soil health.

Development of an evaluation index system for inappropriate hospital admissions after colorectal cancer surgery in the context of enhanced recovery after surgery.

Background: Colorectal cancer (CRC) is one of the most prevalent cancers globally, and its treatment has garnered significant attention. The promotion and application of the Enhanced Recovery After Surgery (ERAS) concept have notably reduced postoperative hospital stay durations for CRC patients and improved recovery efficiency. However, there exist significant discrepancies in the discharge criteria for CRC patients, with a lack of uniformity and specificity in the evaluation standards for postoperative hospital days across different regions and healthcare institutions.

High Magnetoresistance Sensitivity and Anisotropic Magnetotransport Properties in the Chiral Helimagnet CrNbS.

Chiral magnets have recently gained recognition as ideal hosts for topological spin textures, showing significant promise for applications in next-generation spintronic devices. However, chiral magnets are still scarce, and their transport properties have been rarely explored. Here, a chiral magnet, CrNbS, has been synthesized, and its magnetic and transport properties have been systematically investigated.

SIRT3 mitigates neuroinflammation and mitochondrial damage post-hypoxic-ischemic brain injury.

Objective: We aimed to explore the role of SIRT3 in ameliorating neuroinflammation caused by hypoxia-ischemia (HI).

Methods: A rat model of HI was established, and 48 hours prior to constructing the HI model, the rats received an intracerebroventricular injection of a recombinant adeno-associated virus type 9 vector. TTC and Nissl staining assessed the effects of SIRT3 on cerebral infarction and brain atrophy in HI rats.

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.

Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a transient transgene expression cassette was feasible using Ark313, and this serotype outperformed natural serotypes.

Antisymmetric Magnetoresistance in a CrTe/BiTe/CrTe van der Waals Heterostructure Grown by MBE.

The magnetoresistance (MR) of spin valves usually displays a symmetric dependence on the magnetic field. An antisymmetric MR phenomenon has been discovered recently that breaks field symmetry and has the potential to realize polymorphic memory. In this work, centimeter-size and high-quality CrTe/BiTe/CrTe van der Waals (vdWs) heterostructure devices have been prepared using molecular beam epitaxy (MBE).

A comprehensive benchmarking for evaluating TCR embeddings in modeling TCR-epitope interactions.

The complexity of T cell receptor (TCR) sequences, particularly within the complementarity-determining region 3 (CDR3), requires efficient embedding methods for applying machine learning to immunology. While various TCR CDR3 embedding strategies have been proposed, the absence of their systematic evaluations created perplexity in the community. Here, we extracted CDR3 embedding models from 19 existing methods and benchmarked these models with four curated datasets by accessing their impact on the performance of TCR downstream tasks, including TCR-epitope binding affinity prediction, epitope-specific TCR identification, TCR clustering, and visualization analysis.

Predicting early diagnosis of intensive care unit-acquired weakness in septic patients using critical ultrasound and biological markers.

Objective: Early diagnosis of intensive care unit-acquired weakness (ICUAW) is crucial for improving the outcomes of critically ill patients. Hence, this study was designed to identify predisposing factors for ICUAW and establish a predictive model for the early diagnosis of ICUAW.

Methods: This prospective observational multicenter study included septic patients from the comprehensive ICUs of West China Hospital of Sichuan University and 10 other hospitals between September and November 2023.

GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147.

Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro.

Superficial temporal artery-to-middle cerebral artery side-to-side microvascular anastomosis using the in-situ intraluminal suturing technique.

Background: Superficial temporal artery (STA)-middle cerebral artery (MCA) side-to-side microvascular anastomosis can achieve the same clinical effects as traditional STA-MCA end-to-side anastomosis in extracranial-intracranial revascularization surgery, furthermore, STA-MCA side-to-side anastomosis has the lower risk of postoperative cerebral hyperperfusion syndrome (CHS) and the potential to recruit all scalp arteries as the donor sources via self-regulation. Therefore, STA-MCA side-to-side microvascular anastomosis seems to be a revascularization strategy superior to traditional STA-MCA end-to-side anastomosis. In this study, we presented seven cases in which a STA-MCA side-to-side microvascular anastomosis was performed with a 4-5 mm long arteriotomy using the in-situ intraluminal suturing technique.

Modification and Aging Mechanism of Crumb Rubber Modified Asphalt Based on Molecular Dynamics Simulation.

Asphalt modified with treated waste tires has good environmental protection and application value. However, the nano-modification mechanism of crumb rubber (CR) with asphalt is still unclear. This research investigates the mechanism, aging, and interfacial interaction with the aggregate of CR modification asphalt (CRMA).

Exploration of Key Regulatory Factors in Mesenchymal Stem Cell Continuous Osteogenic Differentiation via Transcriptomic Analysis.

Background/objectives: Mesenchymal stem cells (MSCs) possess the remarkable ability to differentiate into various cell types, including osteoblasts. Understanding the molecular mechanisms governing MSC osteogenic differentiation is crucial for advancing clinical applications and our comprehension of complex disease processes. However, the key biological molecules regulating this process remain incompletely understood.

Evaluating the ability of large language models to emulate personality.

For social sciences, recent advancements in Large Language Models (LLMs) have the potential to revolutionize the study of human behaviors by facilitating the creation of realistic agents characterized by a diverse range of individual differences. This research presents novel simulation studies assessing GPT-4's ability to role-play real-world individuals with diverse big five personality profiles. In simulation 1, emulated personality responses exhibited superior internal consistency, but also a more distinct and structured factor organization compared to the human counterparts they were based on.

The long-term intake of milk fat does not significantly increase the blood lipid burden in normal and high-fat diet-fed mice.

After 10 weeks of feeding C57BL/6J mice with a normal diet (ND) or a high-fat diet (HFD), a 7-week intervention with milk fat and whole milk was conducted to assess their long-term effects on host blood lipid levels. The results showed that milk fat and whole milk did not significantly elevate low-density lipoprotein cholesterol (LDL-C) in either ND- or HFD-fed mice. In ND mice, milk fat and whole milk improved gut microbiota diversity and Amplicon Sequence Variants.

Event co-occurrences for prompt-based generative event argument extraction.

Recent works have introduced prompt learning for Event Argument Extraction (EAE) since prompt-based approaches transform downstream tasks into a more consistent format with the training task of Pre-trained Language Model (PLM). This helps bridge the gap between downstream tasks and model training. However, these previous works overlooked the complex number of events and their relationships within sentences.

New Species and Records Expand the Checklist of Cellular Slime Molds (Dictyostelids) in Jilin Province, China.

Dictyostelids represent a crucial element in the protist community, and their abundant presence in Jilin Province underscores their indispensable role in biodiversity conservation. In the present study, a resource survey of dictyostelids used random sampling to collect 28 soil samples from five localities in Changbai Korean Autonomous County, Jilin Province. In addition, a compilation of dictyostelid species reported from Jilin Province was developed, based on a thorough review of the literature.

Development and application of a novel scintillation gel-based 3D dosimetry system for radiotherapy.

Purpose: This study introduced a novel 3D dosimetry system for radiotherapy in order to address the limitations of traditional quality assurance methods in precision radiotherapy techniques.

Methods: The research required the use of scintillation material, optical measurements, and a dose reconstruction algorithm. The scintillation material, which mimics human soft tissue characteristics, served as a both physical phantom and a radiation detector.

Impact of menopausal status on cognitive function in female papillary thyroid carcinoma patients: a longitudinal propensity score matched study.

Purpose: Previous research has documented cognitive deficits in survivors of papillary thyroid carcinoma (PTC).Our longitudinal study with large sample size, aims to assess the impact of menopausal status on cognitive function, elucidate related factors of cognitive impairment, and chart the trajectory of cognitive changes over time in female PTC patients.

Methods: In this longitudinal study, we administered the Montreal Cognitive Assessment (MoCA) to 322 female PTC patients over 40 years old, before surgery and at 3 and 6 months after surgery.

Bioinspired Spatial Compartment of Substrate Molecules and Catalytic Counting Entities in Hierarchical MOFs Initiated for a Dual-Mode Glycoprotein Assay.

Living cell systems possess multiple isolated compartments that can spatially confine complex substances and shield them from each other to allow for feedback reactions. In this work, a bioinspired design of metal-organic frameworks (MOFs) with well-defined multishelled matrices was fabricated as a hierarchical host for multiple guest substances including fluorogenic molecules and catalytic nanoparticles (NPs) at the separated locations for the development of a dual-mode glycoprotein assay. The multispatial-compartmental zeolitic imidazolate framework-8 (ZIF-8) constituents were synthesized via epitaxial shell-by-shell overgrowth to guide the integration and spatial organization of host guests.