NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.

Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are remarkably effective for treating EGFR-mutant non-small cell lung cancer (NSCLC). However, patients inevitably develop acquired drug resistance, resulting in recurrence or metastasis. It is important to identify novel effective therapeutic targets to reverse acquired TKI resistance.

Synthesis, Antifungal Activity and In Silico Study of Novel Quinoline Thioether Derivatives Inspired by Natural Quinoline.

Inspired by natural quinoline, a series of novel quinoline derivatives containing thioether groups were designed and synthesized. All target compounds were characterized using 1H NMR, 13C NMR, and HRMS. Their antifungal activities were evaluated in vitro against ten phytopathogenic fungi.

POSA for fast, amplified and multiplexed protein imaging.

Fluorescent π-conjugated polymers (FCPs) are known for their superior brightness but are still unavailable for highly multiplexed molecular imaging in single cells as they are hydrophobic and lack targeting capability toward biomolecules. Herein, we develop a π-conjugated polymer-based amplification (POSA) method to achieve highly multiplexed signal amplification. Optical amplification by virtue of the high brightness of FCPs makes POSA a simple and quick signal amplification technique that can spatially resolve the distribution of multiplexed proteins in single cells, with a 28- to 126-fold signal amplification effect.

DrBioRight 2.0: an LLM-powered bioinformatics chatbot for large-scale cancer functional proteomics analysis.

Functional proteomics provides critical insights into cancer mechanisms, facilitating the discovery of novel biomarkers and therapeutic targets. We have developed a comprehensive cancer functional proteomics resource using reverse phase protein arrays, incorporating data from nearly 8000 patient samples from The Cancer Genome Atlas and approximately 900 samples from the Cancer Cell Line Encyclopedia. Our dataset includes a curated panel of  nearly 500 high-quality antibodies, covering all major cancer hallmark pathways.

Mechanisms and preventive measures of ALDH2 in ischemia‑reperfusion injury: Ferroptosis as a novel target (Review).

Ischemia‑reperfusion injury (IRI) refers to tissue or organ damage that occurs following a period of inadequate blood supply (ischemia) followed by restoration of blood flow (reperfusion) within a short time frame. This phenomenon is prevalent in clinical conditions such as cardiovascular and cerebrovascular disease, organ transplantation and stroke. Despite its frequency, effective therapeutic strategies to mitigate IRI remain elusive in clinical practice, underscoring the need for a deeper understanding of its molecular mechanisms.

8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop.

As a well-known cancer risk region, the 8q24 locus is frequently amplified in a variety of solid tumors. Here we identify a pseudogene-derived oncogenic lncRNA, ZNF252P, which is upregulated in a variety of cancer types by copy number gain as well as c-Myc-mediated transcriptional activation. Mechanistically, ZNF252P binds and drives "phase separation" of HNRNPK and ILF3 protein in the nucleus and cytoplasm, respectively, to transcriptionally and posttranscriptionally activate c-Myc, thus forming a c-Myc/ZNF252P/c-Myc positive feedback loop.

Kinetics Manipulation Enabled by Solubility Control Toward 19% Organic Solar Cells via Compatible Air Coating.

Blade coating is a promising tool for upscaling organic solar cells (OSCs). However, the performances of blade-coated OSCs still lag behind their spin-coated counterparts, limiting their competitive edge towards commercialization. One of the main reasons is that controlling the film aggregation kinetics and morphology becomes challenging during the transition from spin coating to blade coating, especially when using high boiling point solvents, which can result in excessive aggregation.

GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson's disease.

Parkinson's disease is a progressive neurodegenerative disorder, which is characterized by pathological changes and progressive loss of dopaminergic neurons in the substantia nigra, e.g., endoplasmic reticulum stress.

Assessment of in vitro assays and quantitative determination of selectivity and modality of inhibitors targeting the cell cycle regulating, oncogenic cyclin-dependent kinases.

At the heart of cancer pathology lies the dysregulated cell cycle, which is often driven by aberrant activities of the cell cycle regulating, cyclin-dependent kinases (CDKs). Efforts to harness the therapeutic potential of modulating CDK activities have led to the development of inhibitors with tailored CDK selectivity. However, uniformity in the methods used to evaluate CDK inhibitor selectivity has been lacking and consequently, direct comparison and interpretation of selectivity profiles determined under different assay conditions is difficult.

The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers.

The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance in cancers remain poorly characterized. Here, we perform a systematic analysis of whole-genome and in-house targeted UCE sequencing datasets from more than 3000 patients with cancer of 13,736 UCEs and demonstrate that ncUCE somatic alterations are common. Using a multiplexed CRISPR knockout screen in colorectal cancer cells, we show that the loss of several altered ncUCEs significantly affects cell proliferation.

Perioperative or postoperative adjuvant oxaliplatin with S-1 versus adjuvant oxaliplatin with capecitabine in patients with locally advanced gastric or gastro-oesophageal junction adenocarcinoma undergoing D2 gastrectomy (RESOLVE): final report of a randomised, open-label, phase 3 trial.

Background: The multicentre RESOLVE trial examined the efficacy of perioperative and postoperative S-1 and oxaliplatin (SOX) compared with postoperative capecitabine and oxaliplatin (CapOx) in gastric or gastro-oesophageal junction cancer. Initial analyses did not encompass overall survival owing to the immature data. This paper provides an updated analysis of the survival data from the RESOLVE trial.

Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications.

Esophageal cancer (EC) presents substantial therapeutic challenges due to its high mortality rate and the tendency for diagnosis at advanced stages. Acknowledging the constraints of the existing current treatment paradigm, there is a pressing need for the development of innovative, targeted therapeutic strategies to surpass the current stagnation in survival rate improvements. Recently, microRNAs (miRNAs) have attracted significant attention for their capacity to regulate gene expression at the post-transcriptional level, thereby influencing various cellular processes.

Exploring Pruritus in Bullous Pemphigoid: Analysis of QOL Metrics and Potential Biological Mechanisms.

Bullous pemphigoid is a devastating autoimmune blistering disease with need for improved therapeutics. Limited data are available on the overall burden of pruritus and alterations over time; however, treatment of itch-specific pathways may provide novel therapeutics. In this paper, we analyzed the QOL impact particularly related to itch and determined corresponding changes in intraepidermal nerve fiber density and gene expression.

The impact of spousal retirement on health-an empirical analysis based on CFPS.

Introduction: Health impacts associated with spousal retirement vary significantly across countries and datasets, underscoring the need to examine this relationship within the Chinese context. This study aims to explore how spousal retirement affects individual health in China.

Methods: Utilizing data from the China Family Panel Studies (CFPS) for the years 2014, 2016, 2018, and 2020, this research applies a fuzzy regression discontinuity approach to assess the effects of spousal retirement on health outcomes.

Advances and Challenges of Thrombolytic Therapy for Donation After Circulatory Death Organs.

The demand for organ transplantation has exceeded the global supply of available organs. Donation after circulatory death (DCD) is considered an effective method to solve the disparity between the supply and demand of organs, by expanding the donor pool. However, DCD organs experience long-term damage caused by warm ischemia (WI) and microthrombosis caused by diffuse intravascular coagulation.

Adjuvant non-opioid analgesics decrease in-hospital mortality in targeted patients with acute pancreatitis receiving opioids.

Objectives: Opioid administration in acute pancreatitis (AP) exacerbates its severity, prompting concerns regarding the increased requirement for intensive care and its potential impact on patient survival. We aimed to elucidate the influence of analgesic patterns on mortality among patients with AP hospitalized in the ICU.

Methods: We included 784 patients (198 receiving opioid monotherapy and 586 receiving opioid polytherapy) from the Medical Information Mart for Intensive Care database.

Resilience and vulnerability of post-ostomy patients with early-onset colorectal cancer from the perspective of social-ecological theory: a qualitative study.

Background: The incidence rate of colorectal cancer (CRC) is rising among adults under the age of 50 (early-onset colorectal cancer, EOCRC). Post-ostomy dysfunction, along with negative perceptions due to incorrect public views and a decline in quality of life, has a significant impact on these individuals, their families, and social relationships.

Objective: By understanding the adaptation process of post-ostomy EOCRC(POEOCRC) patients, this study aims to provide information for developing targeted nursing interventions for this population.

Dual-positive gastric cancer: an extremely malignant subtype of gastric cancer with high serum alpha-fetoprotein and carcinoembryonic antigen concentrations.

Background: Alpha-fetoprotein-producing gastric cancer (AFPGC) is a highly malignant subtype of gastric cancer, but solely alpha-fetoprotein may fail to accurately predict the prognosis. Although the utilization of multi tumor markers could improve stratified patient management, such research in AFPGC is still blank. This study seeks to evaluate whether combining multiple tumor markers can enhance risk stratification and identify AFPGC subtypes with poor prognosis.

The rational design of europium complex based electrochemiluminescence sensor for highly efficient carbaryl detection.

To address the issue that most of the reported electrochemiluminescence (ECL) sensors are usually subjected to various complicated chemical modifications, we proposed a sensitive ECL sensor by using a neutral mononuclear lanthanide metal europium complex Eu(L) (L = 2-pyrazol-1-yl-6-(1H-tetrazol-5-yl)-pyridine) as luminophore with simple chemical composition for the accurate detection of carbaryl pesticide residues. The three conjugated tridentate pyrazo-pyridine- tetrazol ligands could put significant effect on the physical and chemical behavior of the central Eu ion, leading to the excellent luminescent performance of the Eu(L) complex enhanced by "antenna effect" of the auxiliary anionic organic ligands. The naphthol obtained from the hydrolysis reaction of carbaryl in an alkaline working solution could effectively and quantitatively quench the luminescence intensity of the Eu(L) complex, which has been theoretically confirmed by the detailed density functional theory (DFT) and time-dependent DFT (TDDFT) calculations, thus obviously strengthening the target detection capability on carbaryl.

Long-term effects of superselective renal artery embolization on renal function after percutaneous nephrolithotomy.

Objectives: To investigate the long-term impact of superselective renal artery embolization (SRAE) on renal function in cases of severe post-percutaneous nephrolithotomy (PCNL) haemorrhage, and to identify the factors associated with the long-term outcome of renal function.

Methods: Patients treated with SRAE for post-PCNL hemorrhage between September 2016 and September 2021 were included. Patients' demographic and clinical data were recorded.

NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.

Pancreatic cancer is characterized by an insidious onset and high degree of malignancy, with a 5-year survival rate of less than 11 %. Perineural invasion (PNI) is one of the pathological features of pancreatic cancer and provides a pathway for distant tumor metastasis, which leads to a poor prognosis. Although NEAT1 promotes the progression of pancreatic cancer, its impact on PNI has not been studied.

: Communication-Efficient Vertical Federated Learning via Dynamic Caching and Feature Selection.

Vertical Federated Learning (VFL) is a promising category of Federated Learning that enables collaborative model training among distributed parties with data privacy protection. Due to its unique training architecture, a key challenge of VFL is high communication cost due to transmitting intermediate results between the Active Party and Passive Parties. Current communication-efficient VFL methods rely on using stale results without meticulous selection, which can impair model accuracy, particularly in noisy data environments.

The Role of Open-Shell Organic Radical in Enhancing Anti-Tumor Photocatalysis Reaction of NIR Light-Activated Photosensitizer.

Open-shell radical materials, which are characterized by unpaired electrons, have led to revolutionary breakthroughs in material science due to their unique optoelectronic properties. However, the involvement of organic radicals in photodynamic therapy (PDT) has rarely been reported or discussed. This work studies two photosensitizer analogs.

Intratumoral oncolytic virus OH2 injection in patients with locally advanced or metastatic sarcoma: a phase 1/2 trial.

Background: Intratumoral oncolytic herpes simplex virus 2-GM CSF (OH2) injection has shown safety and antitumor efficacy in patients with solid tumors. Here, we examined the safety and efficacy of OH2 as a single agent or in combination with HX008, an NMPA-approved PD-1 inhibitor, in locally advanced or metastatic sarcoma patients.

Methods: This multicenter, phase 1/2 trial enrolled patients with injectable sarcoma lesions, who had failed at least 1 or more lines of standard treatment.

Controllable Self-Assembly Morphologies of PPV-Based Block Copolymers.

Poly(p-phenylenevinylene) (PPV) is a classic semiconducting π-conjugated polymer with outstanding optical and electronic properties, which shows important applications in the fields of optoelectronic, such as organic light-emitting diodes (OLEDs), organic solar cells (OSCs), and organic field-effect transistors (OFETs). In the working process of the device, the microstate of PPV decides its property. Therefore, it is significant to achieve ordered morphologies based on PPV at micro scale.