LaZrGaO: Band-Inversion Strategy in Topology-Protected Octahedron for Large Nonlinear Response and Wide Bandgap.

The contradictory relationship between band gaps and the second-harmonic generation (SHG) response constitutes a formidable challenge in the rational design of infrared nonlinear optical (IR NLO) crystals. In oxide-based crystals, the incorporation of strongly distorted octahedra containing d° cations as central elements are a common approach to enhance SHG responses, while inadvertently leading to a significant decrease in band gaps due to the unfavorable energy level splitting. In this study, an innovative "4d/5s electron band-inversion" strategy is introduced to enhance SHG response while preserving a wide band gap within the octahedron-symmetry-protected langasite structure.

Infrared Absorption Edges in Inorganic Optical Crystals: Understanding and Prediction.

The optical transparent region is a crucial parameter for optoelectrical functional crystals. Herein, the relationship between the infrared (IR) absorption edge and phonon frequencies in inorganic optical crystals is investigated. It is demonstrated that the two-phonon absorption mechanism plays a significant role in determining the IR absorption edge in millimeter- and centimeter-level crystals, which are commonly employed for practical applications, and their quantitative correspondence is built based on first-principles calculations.

RhFGF21 protects the skin from UVB irradiation in diabetic mice through the inhibition of epidermal cell apoptosis and macrophage-mediated inflammation via the SIRT1 signaling pathway.

Background: Ultraviolet B (UVB) irradiation can damage skin tissue. Diabetes aggravates skin lesions. Fibroblast growth factor 21 (FGF21) is significantly involved in exerting protective effects and facilitating tissue repair.

Autonomous, Moisture-Driven Flexible Electrogenerative Dressing for Enhanced Wound Healing.

Electrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited in their clinical utility. This study introduces an autonomous, moisture-driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist-electric generator (MEG), an antibacterial hydrogel dressing, and concentric molybdenum (Mo) electrodes to provide a self-sustaining electrical supply and potent antibacterial activity against Staphylococcus aureus and Escherichia coli.

Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery.

Conventional chemotherapy is challenged by its inherent limitations. As an emerging drug delivery system, nanoparticles are easily eliminated by the immune system due to their exogenous nature. Moreover, the lack of long-circulation and tumor-targeting greatly limits their application.

Comparison of clinical features and inflammatory factors between patients with bipolar depression and unipolar depression.

Background: This study aims to compare the differences in clinical features and inflammatory factors between unipolar depression and bipolar depression, and to investigate potential clinical characteristics and peripheral blood biomarkers that could be used to differentiate between these two conditions. Furthermore, the study seeks to establish a predictive model.

Methods: Inpatients from the Shanghai Mental Health Center, admitted between June 2022 and June 2024, were selected as study participants.

SrZn(CNO): An Alkaline Earth and Transition Metal Based Ultraviolet Cyanurate with Large Birefringence.

Birefringent properties of materials have garnered significant interest in both the military and civilian scientific domains. The rational combination of mixed alkaline earth and fully filled transition metal cations in the cyanurates may achieve large birefringence and good transparency in the UV region by regulating planar π-conjugated (CNO) anions. This work successfully synthesized a new metal cyanurate SrZn(CNO) (SZCY) by a solid-state cyclo-trimerization reaction featuring a planar π-conjugated laminar crystal structure.

Increased cardiac macrophages in -deficient hearts: revealing a potential role for macrophage in responding to embryonic myocardial abnormalities.

Macrophages are known to support cardiac development and homeostasis, contributing to tissue remodeling and repair in the adult heart. However, it remains unclear whether embryonic macrophages also respond to abnormalities in the developing heart. Previously, we reported that the structural protein Sorbs2 promotes the development of the second heart field, with its deficiency resulting in atrial septal defects (ASD).

RET-AREAL: A multi-center, real-world data analysis on the efficacy of pralsetinib in acquired RET fusion after resistance to EGFR/ALK-TKIs.

Pralsetinib demonstrated impressive improvement of survival in non-small cell lung cancer (NSCLC) patients harbored de novo RET fusion. However, the efficacy in patients with acquired RET fusion after resistance to EGFR/ALK-TKIs has only been reported on a case-by-case basis, and the strategy for overcoming the acquired RET fusion has not been fully investigated. This multicenter, real-world analysis enrolled 32 patients with unresectable NSCLC harbored acquired RET fusion after resistance to EGFR/ALK-TKIs in 23 centers across China from July 1st, 2018 to Nov 23rd, 2022.

A prospective, phase II, neoadjuvant study based on chemotherapy sensitivity in HR+/HER2- breast cancer-FINEST study.

Background: Hormone receptor-positive (HR+)/humaal growth factor receptor 2-negative (HER2-) breast cancer, the most common breast cancer type, has variable prognosis and high recurrence risk. Neoadjuvant therapy is recommended for median-high risk HR+/HER2- patients. This phase II, single-arm, prospective study aimed to explore appropriate neoadjuvant treatment strategies for HR+/HER2- breast cancer patients.

Neuromorphic-enabled video-activated cell sorting.

Imaging flow cytometry allows image-activated cell sorting (IACS) with enhanced feature dimensions in cellular morphology, structure, and composition. However, existing IACS frameworks suffer from the challenges of 3D information loss and processing latency dilemma in real-time sorting operation. Herein, we establish a neuromorphic-enabled video-activated cell sorter (NEVACS) framework, designed to achieve high-dimensional spatiotemporal characterization content alongside high-throughput sorting of particles in wide field of view.

Bifunctional Design of Ferroelectric-Order and Band-Engineering in Cu:KTN Crystal for Extended Self-Powered Photoelectric Response.

Photoelectric conversion in ferroelectric crystals can support many important applications in modern on-chip technology, but suffering from two problems, low responsive current and narrow responsive range. Especially, wide-gap ferroelectric oxides are only active at short-wavelength ultraviolet region with weak photocurrent at nanoampere levels. Here, a bifunctional design strategy of ferroelectric-order and electronic-band to improve the photocurrent and extend the responsive range simultaneously, is proposed.

Electron-Lattice Synergistic Coordination for Boosting the Electro-Optic Response of the Crystal.

The electro-optic (E-O) response is fundamental where the refractive index of materials can be modulated by the external electric field. Up to now, E-O modulation has become a critical technology in photonics, quantum optics, modern communication, etc. However, the design of E-O crystals with broadband availabilities and large E-O effect is still challenging since the E-O response is contributed by both electrons and phonons.

[Meta-analysis of Organic Carbon in Sandy Soil in Response to Amendment Application].

Proper application of soil amendments can effectively increase the accumulation of soil organic carbon （SOC） in poor soils, thereby enhancing soil fertility level. The impacts of different types of amendments on the SOC content of sandy soils varies widely. Investigating the effects of various amendments on the SOC content of sandy soils and associated key controlling factors provides a scientific basis for formulating strategies to enhance the fertility of sandy soils.

Mediation Analysis of Serum Fibroblast Growth Factor 20 and Poor Prognosis After Ischemic Stroke.

Background: We aimed to examine the relationship between serum FGF20 (fibroblast growth factor 20) levels and stroke prognosis in a multicenter cohort study.

Methods And Results: Patients with ischemic stroke/transient ischemic attack were prospectively recruited from 5 participating centers and followed up at 3 months and 1 year. FGF20 levels were measured using the ELISA method.

Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro.

Background: Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte. Cordycepin, a bioactive compound first isolated from Cordyceps militaris, is an adenosine analog with numerous physiological activities.

Two-way photoswitching norbornadiene derivatives for solar energy storage.

Molecular photoswitches of norbornadiene (NBD) derivatives have been effectively applied in molecular solar-thermal energy storage (MOST) by photoisomerization of NBD to a quadricyclane (QC) state. However, a challenge of the NBD-based MOST system is the lack of a reversible two-way photoswitching process, limiting conversion from QC to thermal and catalytic methods. Here we design a series of NBD derivatives with a combination of acceptor and donor units to achieve two-way photoswitching, which can optically release energy by back-conversion from QC to NBD.

The Role of PLATZ6 in Raffinose Family Oligosaccharides Loading of Leaves via PLATZ Family Characterization in Cucumber.

The () genes, a novel cluster of plant-specific zinc-finger-dependent DNA-binding proteins, play a crucial role in regulating stress response and plant development. However, there has been little study focus on the role of the cucumber PLATZ family in assimilating loading in leaves. (1) In this study, a total of 12 genes were identified from the cucumber genome.

Extending mid-infrared wavelength to 6.84 μm in oxide nonlinear optical crystal via birefringence dispersion management.

Extending lasing wavelengths to the mid-infrared (MIR) spectrum is vital for both civilian and military applications; however, it remains challenging when employing oxide nonlinear optical crystals. In this study, we report the generation of MIR nanosecond pulses via difference frequency generation (DFG) with a near-IR pump using a newly designed langasite (LGS) crystal, La(NbTa)GaO (LGNT), which incorporates birefringence dispersion management techniques with LaGaNbO (LGN) as a template. Due to the improved effective nonlinear coefficients and the maintained IR cutoff relative to LGN, the tunable DFG laser in LGNT extended from 4.

Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthood.

Background: Hematopoietic stem progenitor cells (HSPCs) undergo phenotypical and functional changes during their emergence and development. Although the molecular programs governing the development of human hematopoietic stem cells (HSCs) have been investigated broadly, the relationships between dynamic metabolic alterations and their functions remain poorly characterized.

Methods: In this study, we comprehensively described the proteomics of HSPCs in the human fetal liver (FL), umbilical cord blood (UCB), and adult bone marrow (aBM).