B-CD8 T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody.

P3 is a murine, germline, IgM mAb that recognizes -glycolylated gangliosides and other self-antigens. This antibody is able to induce an anti-idiotypic IgG response and B-T idiotypic cascade, even in the absence of any adjuvant or carrier protein. P3 mAb immunization induces the expression of activation markers in a significant percentage of B-1a cells in vivo.