Integrated SERS-Microfluidic Sensor Based on Nano-Micro Hierarchical Cactus-like Array Substrates for the Early Diagnosis of Prostate Cancer.

The detection and analysis of cancer cell exosomes with high sensitivity and precision are pivotal for the early diagnosis and treatment strategies of prostate cancer. To this end, a microfluidic chip, equipped with a cactus-like array substrate (CAS) based on surface-enhanced Raman spectroscopy (SERS) was designed and fabricated for the detection of exosome concentrations in Lymph Node Carcinoma of the Prostate (LNCaP). Double layers of polystyrene (PS) microspheres were self-assembled onto a polyethylene terephthalate (PET) film to form an ordered cactus-like nanoarray for detection and analysis.

Robot Calibration Sampling Data Optimization Method Based on Improved Robot Observability Metrics and Binary Simulated Annealing Algorithm.

As the societal demand for precision in industrial robot operations increases, calibration can enhance the end-effector positioning accuracy of robots. Sampling data optimization plays an important role in improving the calibration effect. In this study, a robot calibration sampling point optimization method based on improved robot observability metrics and a Binary Simulated Annealing Algorithm is proposed.

Research on Bearing Surface Scratch Detection Based on Improved YOLOV5.

Bearings are crucial components of machinery and equipment, and it is essential to inspect them thoroughly to ensure a high pass rate. Currently, bearing scratch detection is primarily carried out manually, which cannot meet industrial demands. This study presents research on the detection of bearing surface scratches.

Packaged WGM MBR sensor for high-performance temperature measurement using CNN-based multimode barcode images.

The whispering gallery mode (WGM) optical microresonator sensors are emerging as a promising platform for precise temperature measurements, driven by their excellent sensitivity, resolution and integration. Nevertheless, challenges endure regarding stability, single resonant mode tracking, and real-time monitoring. Here, we demonstrate a temperature measurement approach based on convolutional neural network (CNN), leveraging the recognition of multimode barcode images acquired from a WGM microbottle resonator (MBR) sensor with robust packaged microresonator-taper coupling structure (packaged-MTCS).

Accuracy improvement of multi-view 3D laser scanning measurements based on point cloud error correction and global calibration optimization.

Multi-camera laser scanning measurement is emerging as a pivotal element in three-dimensional (3D) optical measurements. It reduces occlusion and enables the gathering of more 3D data. However, it also increases the difficulty of system algorithms in obtaining high measurement accuracy.

Microfluidics-aided fabrication of 3D micro-nano hierarchical SERS substrate for rapid detection of dual hepatocellular carcinoma biomarkers.

The simultaneous analysis of trace amounts of dual biomarkers is crucial in the early diagnosis, treatment, and prognosis of hepatocellular carcinoma (HCC). In this study, we prepared SERS-active hydrogel microparticles (SAHMs) with 3D hierarchical gold nanoparticles (AuNPs) micro-nanostructures by microdroplet technology and synthesis, which demonstrated high reproducibility and sensitivity. Compared with traditional 2D SERS substrates, this newly prepared 3D SERS substrate provided a high density of nano-wrinkled structures and numerous AuNPs.

A micro-nano interface integrated SERS-based microfluidic sensor for miRNA detection using DNAzyme walker amplification.

Background: Precise and specific miRNA detection plays a vital role in exploring development mechanisms of cancer disease, thereby it can significantly improve relevant prevention and treatment strategies.

Results: In this work, a surface-enhanced Raman spectroscopy (SERS)-based microfluidic chip has been devised with a microcone array SERS substrate (MCASS) for the miR-141 detection. This substrate excels in unique SERS activity and large surface area for DNA oligonucleotide modification.

Efficient 3D scanning measurement system based on asymmetric trinocular vision and a multi-line laser.

The laser scanning measurement system has a pivotal role in precision measurement thanks to the non-contacting and low-cost advantages, but traditional methods and systems are inadequate in terms of accuracy, efficiency, and adaptability. In this study, an efficient 3D scanning measurement system based on asymmetric trinocular vision and a multi-line laser is developed to improve the measurement performance. The system design, working principle, and 3D reconstruction method are explored, as well as the innovation of the developed system.

An Adaptive Hybrid Sampling Method for Free-Form Surfaces Based on Geodesic Distance.

High precision geometric measurement of free-form surfaces has become the key to high-performance manufacturing in the manufacturing industry. By designing a reasonable sampling plan, the economic measurement of free-form surfaces can be realized. This paper proposes an adaptive hybrid sampling method for free-form surfaces based on geodesic distance.

Single-shot 3D shape measurement based on RGB dot patterns and stereovision: retraction.

The referenced article [Opt. Express30, 28220 (2022)10.1364/OE.

Rapid simultaneous SERS detection of dual myocardial biomarkers on single-track finger-pump microfluidic chip.

Acute myocardial infarction (AMI) is a serious disease with high mortality that afflicts many people around the world. The main cause of death from AMI was the inaccurate early diagnosis, which resulted from the medical treatment might be a delay. Therefore, it is crucial to achieve the rapid detection of AMI.

An optical method based auto-collimation for measuring five degrees of freedom error motions of rotary axis.

The paper presents an optical method based on auto-collimation to simultaneously measure five degrees of freedom error motions of the rotary axis. The proposed method consists of the collimated lasers, beam splitters, focusing lens, quadrant photodiode detectors, a high-precision steel ball, and a special mirror fixed to the rotary axis. The mathematical model is established byoptical ray tracing, and the corresponding optical path is also simulated by OpticStudio.

SERS-Based Immunoassay of Myocardial Infarction Biomarkers on a Microfluidic Chip with Plasmonic Nanostripe Microcones.

We developed a new plasmonic nanostripe microcone array (PNMA) substrate-integrated microfluidic chip for the simultaneous surface-enhanced Raman scattering (SERS)-based immunoassay of the creatine kinase MB isoenzyme (CK-MB) and cardiac troponin (cTnI) cardiac markers. The conventional immunoassay usually employs a microtiter plate as the solid capture plate to form the immunocomplexes. However, the two-dimensional (2D) surface of the microtiter plate limits the capture efficiency of the target antigens due to the steric hindrance effect.

Regulation of soliton inside microresonators with multiphoton absorption and free-carrier effects.

The influence of frequency detuning on the field in silicon microresonators with multiphoton absorption and FC effect is investigated. In this study, results show that frequency detuning facilitates soliton generation. With appropriate frequency detuning, not only bright solitons but also dark ones can be excited in silicon microresonators, which compensates for the absence of solitons with multiphoton absorption and FC.

Single-shot 3D shape measurement based on RGB dot patterns and stereovision.

One-shot projection structured light 3D measurement is a method to establish the stereo matching relationship and reconstruct 3D shape by projecting one pattern. However, the traditional stereo matching algorithm does not solve the problem of low matching accuracy and matching efficiency, which fundamentally limits the accuracy of 3D measurement. As the projector and imaging systems have daily higher resolution and imaging quality, RGB dots projection has more application prospects because of its ability to establish a stereo matching relationship through one projection.

Absolute distance measurement to coaxial multi-targets based on optical balanced cross-correlation using a single femtosecond laser.

We describe a high-precision ranging method based on an optical balanced cross-correlation system with a scanning repetition rate using a single femtosecond laser. By scanning the repetition rate of a laser, measuring pulses can be overlapped with reference pulses. It is an effective method to make reference pulses overlap with coaxial multiple target pulses without additional mechanical devices.

Robust and accurate sub-pixel extraction method of laser stripes in complex circumstances.

Line laser scanning measurement is a major area of interest within the field of 3D laser scanning measurement. Traditionally, sub-pixel extraction of laser stripes is a dominant point for line laser scanning measurement. In particular, the noise separation of laser stripe images and the accuracy of feature extraction of the laser stripe are the main challenges for sub-pixel extraction of laser stripes in complex circumstances.

Spherical wavefront measurement on modified cyclic radial shearing interferometry.

We propose a radial shearing interferometric approach to measure spherical wavefronts as both of the reflective and transmissive optical configurations. The modified cyclic radial shearing interferometer uses a single lens in the optical layout, which can conveniently adjust the radial shearing ratio between two shearing spherical wavefronts, and the use of a polarization camera enables to reconstruct the wavefront by a single image. The wavefront mapped onto the camera plane can be identified and quantified throughout an optimized wavefront reconstruction algorithm.

Green light-driven acetone gas sensor based on electrospinned CdS nanospheres/CoO nanofibers hybrid for the detection of exhaled diabetes biomarker.

Morphological and structural characteristics of semiconductors have a significant impact on their gas sensing characteristics. Reasonable design and synthesis of heterojunctions with special structures can effectively improve sensor performance. Herein, a cobalt oxide (CoO) nanofibers/cadmium sulfide (CdS) nanospheres hybrid was synthesized by an electrospinning method combined with a hydrothermal method to detect acetone gas.

Simultaneous single-cell phenotype analysis of hepatocellular carcinoma CTCs using a SERS-aptamer based microfluidic chip.

Hepatocellular carcinoma (HCC) is a harmful malady that truly debilitates human health, and hence it is of significance to isolate and on-line profile the phenotype of HCC cells for further diagnosis and therapy. We developed a novel strategy for efficient capture and heterogeneous phenotype analysis of circulating tumor cells (CTCs) at the single-cell level based on surface-enhanced Raman scattering (SERS) fingerprint characteristics. Herein, a new microfluidic chip with lantern-like bypass structure was designed to capture CTCs by their large size from whole blood.

Electrospinning of Flexible Poly(vinyl alcohol)/MXene Nanofiber-Based Humidity Sensor Self-Powered by Monolayer Molybdenum Diselenide Piezoelectric Nanogenerator.

Two-dimensional material has been widely investigated for potential applications in sensor and flexible electronics. In this work, a self-powered flexible humidity sensing device based on poly(vinyl alcohol)/TiCT (PVA/MXene) nanofibers film and monolayer molybdenum diselenide (MoSe) piezoelectric nanogenerator (PENG) was reported for the first time. The monolayer MoSe-based PENG was fabricated by atmospheric pressure chemical vapor deposition techniques, which can generate a peak output of 35 mV and a power density of 42 mW m.

Correction of the air refractive index using a two-color method for absolute distance measurement without a dead zone.

In the fields of satellite formation, large-scale manufacturing, and ultra-precision machining, high-precision ranging based on the femtosecond laser is one of the necessary technologies. However, the fluctuations of the air refractive index and the limited tuning range of repetition rate restrict the measurement precision and range. Using only one femtosecond comb that corrects the air refractive index simultaneously, a method for ranging without the dead zone of measurement is described.

Multifunctional Latex/Polytetrafluoroethylene-Based Triboelectric Nanogenerator for Self-Powered Organ-like MXene/Metal-Organic Framework-Derived CuO Nanohybrid Ammonia Sensor.

Self-powered sensors are crucial in the field of wearable devices and the Internet of Things (IoT). In this paper, an organ-like TiCT MXene/metal-organic framework-derived copper oxide (CuO) gas sensor was powered by a triboelectric nanogenerator (TENG) based on latex and polytetrafluoroethylene for the detection of ammonia (NH) at room temperature. The peak-to-peak value of open-circuit voltage and short-circuit current generated by the prepared TENG can reach up to 810 V and 34 μA, respectively.

Improving the measuring length accuracy of articulated arm coordinate measuring machine using artificial neural network.

A new method for further improving the measuring length accuracy of the articulated arm coordinate measuring machine (AACMM) is proposed. The detailed procedure of the proposed method involves kinematic error calibration with the Levenberg-Marquardt algorithm and then non-kinematic error (such as link deflection, thermal errors, and error motions of the rotation shaft) compensation with a back-propagation neural network optimized by the mind evolutionary algorithm. In order to verify the effectiveness and correctness of the proposed method, the simulation and experiment were carried out on an AACMM.