High expression of TARS is associated with poor prognosis of endometrial cancer.

Introduction: Endometrial cancer is the second largest and most common cancer in the world. It is urgent to explore novel biomarkers.

Methods: Data were obtained from The Cancer Genome Atlas (TCGA) database.

Radioprotective countermeasures for radiation injury (Review).

A series of physiological and pathological changes occur after radiotherapy and accidental exposure to ionizing radiation (IR). These changes cause serious damage to human tissues and can lead to death. Radioprotective countermeasures are radioprotective agents that prevent and reduce IR injury or have therapeutic effects.

AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC cells through Nrf2/xCT Pathway.

Radiotherapy has been used for decades in the treatment of liver cancer. We previously found that adiponectin receptor (AdipoR1) is a prognostic biomarker for hepatoma carcinoma (HCC) after stereotactic body radiation therapy (SBRT) and blocking AdipoR1 enhances radiation sensitivity in hepatoma carcinoma cells. In the current study, we aimed to elucidate the roles of AdipoR1 in ionizing radiation- (IR-) induced radiosensitivity by activating ferroptosis pathway in HCC cells.

Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review).

Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis and lead to oxidative stress that may result in cell death. However, the tumor cell microenvironment is dynamic and responds to radiotherapy by activating numerous cellular signaling pathways.

The Dual Regulation Effects of ESR1/NEDD4L on SLC7A11 in Breast Cancer Under Ionizing Radiation.

Radiotherapy is one of the most important treatments for breast cancer. Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, whether ionizing radiation (IR) could induce ferroptosis in breast cancer and how it works remain unknown.

Blocking Adipor1 enhances radiation sensitivity in Hepatoma Carcinoma Cells.

In this study, we aimed to elucidate the roles of Adipor1 in radiation-induced cell death of Hepatocellular carcinoma (HCC). The human HCC cell line MHCC97-H and HepG2 were used to investigate the underlying mechanisms. Western blotting was used to detect protein expression, and flow cytometry was used to detect cell cycle and cell death.

Clinicopathological and Prognostic Significance of PRMT5 in Cancers: A System Review and Meta-Analysis.

Purpose: Since protein arginine methyltransferase 5 (PRMT5) is abnormally expressed in various tumors, in this study we aim to assess the association between PRMT5 and clinicopathological and prognostic features.

Methods: Electronic databases including PubMed, Web of Science, Scopus, ScienceDirect, and the Cochrane Library were searched until July 25, 2021. The critical appraisal of the eligible studies was performed using the Newcastle-Ottawa Quality Assessment Scale.