Bicontinuous Block Copolymer Microparticles through Hydrogen-Bonding-Mediated Dual Phase Separation between Polymer Segments and Fluorinated Additives.

Bicontinuous microparticles have advanced transport, mechanical, and electrochemical properties and show promising applications in energy storage, catalysis, and other fields. However, it remains a great challenge to fabricate bicontinuous microparticles of block copolymers (BCPs) by controlling the microphase separation due to the extremely narrow region of a bicontinuous structure in the phase diagram. Here, we demonstrate a strategy to balance the phase separation of BCPs and fluorinated additives at different length scales in emulsion droplets, providing a large window to access bicontinuous microparticles.

Photonic hydrogels combining the slow photon effect and NO gas therapy for synergetic enhanced photodynamic antibacterial therapy.

Photodynamic therapy (PDT) offers potential for combating bacterial infections through the generation of reactive oxygen species (ROS). However, the antibacterial efficiency of PDT is largely impeded by the limited photon absorption of photosensitizers and the short diffusion length and lifespan of ROS. Herein, we present a light-harvesting platform based on l-arginine-modified photonic hydrogels loaded with new indocyanine green (PG@Arg/IR820) for synergizing the slow photon effect with NO gas therapy to enhance PDT antibacterial efficiency.

Structurally-colored adhesives for sensitive, high-resolution, and non-invasive adhesion self-monitoring.

Polymeric adhesives are critical in many applications, from daily life to implantable devices and soft robotics. Monitoring adhesion in a real-time and convenient manner before premature failure is essential yet challenging. Herein, we present structurally-colored adhesives for sensitive, high-resolution, and non-invasive adhesion self-monitoring via distinct color change for detecting subtle deformation and debonding.

Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy.

Combined photodynamic and photothermal therapy (PDT and PTT) can achieve more superior therapeutic effects than the sole mode by maximizing the photon utilization, but there remains a significant challenge in the development of related single-molecule photosensitizers (PSs), particularly those with type I photosensitization. In this study, self-assembly of squaraine dyes (SQs) is shown to be a promising strategy for designing PSs for combined type I PDT and PTT, and a supramolecular PS (TPE-SQ7) has been successfully developed through subtle molecular design of an indolenine SQ, which can self-assemble into highly ordered H-aggregates in aqueous solution as well as nanoparticles (NPs). In contrast to the typical quenching effect of H-aggregates on reactive oxygen species (ROS) generation, our results encouragingly manifest that H-aggregates can enhance type I ROS (OH) generation by facilitating the intersystem crossing process while maintaining a high PTT performance.

Photon Management Enabled by Opal and Inverse Opal Photonic Crystals: from Photocatalysis to Photoluminescence Regulation.

Light is a promising renewable energy source and can be converted into heat, electricity, and chemical energy. However, the efficiency of light-energy conversion is largely hindered by limited light-absorption coefficients and the low quantum yield of current-generation materials. Photonic crystals (PCs) can adjust the propagation and distribution of photons because of their unique periodic structures, which offers a compelling platform for photon management.

Colloidal Photonic Composites with a Long-Range Order by Hot-Pressing Polymer Brush-Grafted Silica Colloids.

Colloidal photonic composites (CPCs) are unique optical materials that combine flexible and responsive polymers with colloidal photonic crystals, and they have promising applications in colorful displays, optical anticounterfeiting, and visual sensors. However, conventional self-assembly strategies for constructing CPCs via solvent evaporation have faced limitations due to the meticulous regulation required during the evaporation process and typically long preparation durations. Here, we present an external force method to achieve a long-range ordered arrangement in CPCs by hot-pressing poly(2-[[(butylamino)carbonyl]oxy]ethyl acrylate (PBCOE)) brush-grafted silica colloidal particles (SiO--PBCOE).

Scalable production of structurally colored composite films by shearing supramolecular composites of polymers and colloids.

Structurally colored composite films, composed of orderly arranged colloids in polymeric matrix, are emerging flexible optical materials, but their production is bottlenecked by time-consuming procedures and limited material choices. Here, we present a mild approach to producing large-scale structurally colored composite films by shearing supramolecular composites composed of polymers and colloids with supramolecular interactions. Leveraging dynamic connection and dissociation of supramolecular interactions, shearing force stretches the polymer chains and drags colloids to migrate directionally within the polymeric matrix with reduced viscous resistance.

Polyphenol-sodium alginate supramolecular injectable hydrogel with antibacterial and anti-inflammatory capabilities for infected wound healing.

Injectable hydrogel has attracted appealing attention for skin wound treatment. Although multifunctional injectable hydrogels can be prepared by introducing bioactive ingredients with antibacterial and anti-inflammatory capabilities, their preparation remains complicated. Herein, a polyphenol-based supramolecular injectable hydrogel (PBSIH) based on polyphenol gallic acid and biological macromolecule sodium alginate is developed as a wound dressing to accelerate wound healing.

Clinical efficacy and safety of adjuvant EGFR-TKIs for resected stage IB lung adenocarcinoma: A real-world study based on propensity score matching.

Background: Adjuvant therapy for stage IB non-small cell lung cancer remains debatable. In this real-world study, we evaluate the efficacy and safety of adjuvant epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for resected stage IB lung adenocarcinoma.

Methods: This real-world study recruited 249 patients diagnosed with stage IB disease after surgical resection between January 2013 and September 2021.

Mitochondria-Targeting Upconversion Nanoparticles@MOF for Multiple-Enhanced Photodynamic Therapy in Hypoxic Tumor.

The effect of photodynamic therapy (PDT) is severely limited by tumor hypoxia and the short half-life of reactive oxygen species (ROS). Herein, we constructed a near-infrared (NIR) light-regulated PDT nanoplatform (TPP-UCNPs@MOF-Pt) consisting of an upconversion nanoparticle (UCNP) core and porphyrin-based metal-organic framework (MOF) shell with platinum nanoparticles (PtNPs) and a mitochondria-targeting triphenylphosphine (TPP) group on the surface. TPP-UCNPs@MOF-Pt could effectively relieve the tumor hypoxia by converting intracellular HO to oxygen (O) and elevated the ROS level to enhance PDT efficacy under NIR light irradiation.

Mechanically Robust Dissolving Microneedles Made of Supramolecular Photosensitizers for Effective Photodynamic Bacterial Biofilm Elimination.

Bacterial biofilms pose severe threats to public health worldwide and are intractable by conventional antibiotic treatment. Antimicrobial photodynamic therapy (PDT) is emerging as a promising strategy for eradicating biofilms by virtue of low invasiveness, broad-spectrum antibacterial activity, and nondrug resistance. However, its practical efficacy is impeded by the low water solubility, severe aggregation, and poor penetration of photosensitizers (PSs) into the dense extracellular polymeric substances (EPS) of biofilms.

Supramolecular Dissolving Microneedle Patch Loading Hydrophobic Glucocorticoid for Effective Psoriasis Treatment.

Glucocorticoid-based creams are commonly used for treatments of psoriatic skin lesions while showing poor permeation because the thickened stratum corneum severely limits drug absorption. Although dissolving microneedle (DMN) patches have been employed in treating skin disease by virtue of their direct target to the lesion site, conventional DMN patches are generally fabricated from the water-soluble matrix, making them difficult to efficiently encapsulate hydrophobic glucocorticoids. Here, we develop a mechanically robust supramolecular DMN composed of hydroxypropyl β-cyclodextrin (HPCD) to effectively and uniformly load triamcinolone acetonide (TA).

Robust Underwater Adhesion of Catechol-Functionalized Polymer Triggered by Water Exchange.

Adhesives with strong and stable underwater adhesion performance play a critical role in industrial and biomedical fields. However, achieving strong underwater adhesion, especially in flowing aqueous and blood environments, remains challenging. In this work, a novel solvent-exchange-triggered adhesive of catechol-functionalized polyethylenimine ethoxylated is presented.

Trace Explosive Detection Based on Photonic Crystal Amplified Fluorescence.

With increasing demand for public security and environmental protection, it is highly desirable to develop strategies to identify trace explosives (e. g., 2,4,6-trinitrotoluene (TNT)).

Photothermal Hydrogels for Promoting Infected Wound Healing.

Photothermal therapies (PTT), with spatiotemporally controllable antibacterial capabilities without inducing resistance, have shown encouraging prospects in the field of infected wound treatments. As an important platform for PTT, photothermal hydrogels exhibit attractive advantages in the field of infected wound treatment due to their excellent biochemical properties and have been intensively explored in recent years. This review summarizes the progress of the photothermal hydrogels for promoting infected wound healing.

Solvent-Responsive Invisible Photonic Patterns with High Contrast for Fluorescence Emission Regulation and Anti-Counterfeiting.

Invisible photonic patterns (IPPs) are photonic materials that can display hidden patterns under external stimulation and are attractive in anti-counterfeiting devices and information storage. In this work, we report a solvent-responsive invisible photonic pattern (SRIPP) with high contrast by polymerizing two monomers of acrylamide (AAm) and poly(ethylene glycol) methacrylate (PEGMA) with different solubility parameters in different regions of poly(hydroxyethyl methacrylate) photonic gels. The two regions with different solvent responsiveness can shrink and swell in the same environment, thus causing the colors of different regions of photonic gel to shift in opposite directions from the initial state.

Strong and Tough Supramolecular Microneedle Patches with Ultrafast Dissolution and Rapid-Onset Capabilities.

Dissolving microneedle (DMN) patches are emerging as a minimally invasive and efficient transdermal drug delivery platform. Generally, noncrystalline, water-soluble, and high-molecular-weight polymers are employed in DMNs because their sufficient intermolecular interactions can endow the DMNs with necessary mechanical strength and toughness. However, high viscosity and heavy chain entanglement of polymer solutions greatly hinder processing and dissolution of polymeric DMNs.