Publications by authors named "Liana Van Grieken"
Article Synopsis
- Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare skin cancer caused by harmful CD30+ T cells, yet its genetic origins remain unclear.
- * A study involving 12 patients was conducted using advanced genetic profiling methods, revealing various genetic changes linked to cellular processes like the cell cycle and T-cell function.
- * Findings suggest that targeting specific signaling pathways, especially the PI-3-K/AKT pathway, could lead to new treatment options for patients whose cancer does not respond to standard therapies.
Motivation: Genes involved in coordinated biological pathways, including metabolism, drug resistance and virulence, are often collocalized as gene clusters. Identifying homologous gene clusters aids in the study of their function and evolution, however, existing tools are limited to searching local sequence databases. Tools for remotely searching public databases are necessary to keep pace with the rapid growth of online genomic data.
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