Publications by authors named "Liana Marengo de Medeiros"
Article Synopsis
- Cofilin-1 is crucial for regulating the dynamics of the actin cytoskeleton and is linked to neurotoxicity in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's.
- Dysfunction of cofilin-1 may contribute to cytoskeletal stress, impacting cellular processes and potentially leading to neurodegeneration through the formation of cofilin/actin rods.
- These rods initially serve as a protective response to mitochondrial damage, but prolonged stress may cause them to hinder neuronal function further.
Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine.
Fernanda Martins Lopes Giovana Ferreira Londero Liana Marengo de Medeiros Leonardo Lisbôa da Motta Guilherme Antônio Behr
Neurotox Res
August 2012
It is well established that oxidative stress plays a major role in several neurodegenerative conditions, like Parkinson disease (PD). Hence, there is an enormous effort for the development of new antioxidants compounds with therapeutic potential for the management of PD, such as synthetic organoselenides molecules. In this study, we selected between nine different synthetic organoselenides the most eligible ones for further neuroprotection assays, using the differentiated human neuroblastoma SH-SY5Y cell line as in vitro model.
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