Publications by authors named "Lian-zhong Zhang"

Article Synopsis
  • A systematic review and meta-analysis were conducted to compare the effectiveness of whole family-based treatment for Helicobacter pylori (H. pylori) versus treatment for single-infected patients, focusing on eradication rates and recurrence.
  • The analysis included 12 studies, revealing that the whole family-based treatment group showed a higher eradication rate (OR=2.93) and significantly lower recurrence rate (OR=0.3) compared to the single-infected patient group.
  • The findings suggest that treating the whole family for H. pylori can improve eradication outcomes and decrease the chances of recurrence, particularly in children, while having no significant difference among spouses.
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Aim: The purpose of this study is to observe the volume change of prostate and laser-ablated lesions in the canine and to explore the mechanism and clinical significance through histopathology.

Materials And Methods: Transperineal laser ablation (TPLA) was performed under the guidance of transrectal ultrasound (TRUS) in eight canines. Two canines were sacrificed 1 day and 1 week after TPLA, respectively.

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The prognosis of right heart enlargement varies according to different etiologies. The purpose of this study was to investigate the characteristics of echocardiogram, surgical treatment, chromosome and prognosis for fetal right heart enlargement.The foetal echocardiogram was performed on 3987 pregnant women, and then 88 fetuses with right heart enlargement were identified.

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The aim of this study was to explore the effects of nonvalvular atrial fibrillation (NVAF) on the structure and function of mitral valve and analyze independent risk factors of moderate to severe mitral regurgitation (MR) by quantitative measurement of mitral parameters using real-time 3-dimensional transesophageal echocardiography.This study included 30 subjects with sinus rhythm group, and 65 patients with NVAF. The 65 patients with NVAF were divided into 35 with paroxysmal atrial fibrillation group and 30 with persistent atrial fibrillation.

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Objective: The objective of this study was to evaluate the feasibility of online real time three-dimensional transesophageal echocardiography (RT3DTEE) in the measurement of left atrial appendage (LAA) orifice size. We also analyzed the correlation between LAA ejection fraction (EF) and its peak empty velocity (PEV).

Methods: There were 91 subjects enrolled in this study, with 46 patients with AF and 45 individuals with sinus rhythm (SR).

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Article Synopsis
  • Tetralogy of Fallot is a common congenital heart condition, but its genetic causes are not well understood, prompting this study to investigate genetic variants using whole exome sequencing.
  • The researchers analyzed DNA from eight small families to find specific genetic differences, discovering sixteen single nucleotide polymorphisms (SNPs) and eight small insertions/deletions (InDels) linked to the condition.
  • Their findings highlighted several novel genetic mutations that could be responsible for isolated Tetralogy of Fallot, enhancing the understanding of its pathology.
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Background: Little information is available regarding the penetrance of 1q21.1 copy number variants (CNVs). In the present study, we explored the clinical significance of 1q21.

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Article Synopsis
  • A study analyzed chromosome karyotypes and genome-wide copy number variations (CNVs) in 86 patients with tetralogy of Fallot (TOF) to understand its pathogenesis and aid genetic counseling and prenatal diagnosis.
  • All patients had normal karyotypes, but CNVs were found in 11 individuals, including deletions and duplications in specific chromosome regions.
  • The use of array-comparative genomic hybridization (aCGH) proved effective in detecting CNVs, offering insights into congenital heart disease and validating the importance of genetic testing for TOF.
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Objective: To provide a basis for evaluating the prognosis of small left heart system development in fetuses, we analyzed its related factors.

Methods: The fetal echocardiogram was performed in 3859 pregnant women, and then small left heart system development was identified in 69 fetuses. The data of prenatal and postnatal echocardiograms, postnatal cardiac surgical treatment, chromosome and autopsy after induced labor were analyzed in the 69 fetuses.

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Objectives: To explore the application of instantaneous wave intensity for early diagnosis of systemic lupus erythematosus (SLE)-induced atherosclerosis, we observed carotid elasticity by instantaneous wave intensity in premenopausal women with SLE.

Methods: The study included 3 groups (each group with 30 participants): SLE1 (course of disease <5 years), SLE2 (course of disease ≥5 years) and healthy control. Carotid parameters, including instantaneous acceleration wave intensity, instantaneous deceleration wave intensity, negative area, stiffness constant, wave intensity pulse wave velocity, stiffness constant pulse wave velocity, pressure strain elastic modulus, arterial compliance, augmentation index, and intima-media thickness, were measured.

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The structural organization, the number of hydrogen bonds (H bond), and the self- and mutual diffusion coefficients of ethanol-water mixtures were studied by molecular dynamics simulation. It was found that both the numbers of H bonds per water and per ethanol decrease as the mole fraction of ethanol increases. The composition dependences and the relationships between the self- and the mutual diffusion coefficients were further discussed.

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