[Repair of calvarial defect using a tissue-engineered bone with simvastatin-loaded β-tricalcium phosphate scaffold and adipose derived stem cells in rabbits].

Purpose: The osteogenic-angiogenic differentiation effects of simvastatin (Sim) were explored on adipose tissue-derived stem cells (ASCs). A tissue-engineered bone with simvastatin loaded β-tricalcium phosphate (β-TCP) scaffold and ASCs was constructed to repair the calvarial defect in rabbits.

Methods: ASCs were obtained from the groin of rabbits.

Osteogenic potential of bone marrow stromal cells derived from streptozotocin-induced diabetic rats.

Type 1 diabetes mellitus (T1DM) is associated with a series of bone complications, which are still a great challenge in the clinic. Bone marrow stromal cells (BMSCs) are crucial to bone remodeling and are attractive candidates for tissue engineering. Hence, we aimed to investigate whether impaired functions of BMSCs play a role in the pathogenesis of bone complications associated with T1DM.