Publications by authors named "Lian-Yu Li"
Article Synopsis
- Cognitive dysfunction is a common issue linked to chronic insomnia, and Liuwei Anshen Capsules (LAC) have shown promise in alleviating insomnia-related complications like dementia and anxiety, although their active compounds and mechanisms are not fully understood.
- The study aims to identify the active ingredients in LAC and their effects on cognitive impairment due to sleep deprivation, utilizing methods such as serum pharmacochemistry, network pharmacology, and experimental validation.
- Results indicated that LAC contains 85 active ingredients, with several key targets and pathways identified, and it successfully improved cognitive function in sleep-deprived rats while regulating several proteins and inflammatory markers, suggesting its therapeutic potential.
This study employed network pharmacology to investigate the effect of Guizhi Gancao Decoction(GGD) on myocardial ischemia-reperfusion injury(MI/RI) in rats and decipher the underlying mechanism. Firstly, the chemical components and targets of GGD against MI/RI were searched against the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP), SwissTargetPrediction, and available articles. STRING and Cytoscape 3.
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