Correlation of local and serum CircHIPK3 expressions with the progression of liver fibrosis/cirrhosis.

Background And Study Aims: This study was aimed to validate the correlation of circular RNA HIPK3 (CircHIPK3) expression in serum and tissues with the progression of liver fibrosis (LF) and liver cirrhosis (LC).

Patients And Methods: Serum CircHIPK3 expressions were detected in 120 patients with LF/LC and 120 healthy controls (HCs). CircHIPK3 expression in tissues was detected in 120 fibrotic liver tissues and compared to 57 healthy liver tissues from patients with hepatic hemangioma.

Serum Fractalkine Levels Were Positively Associated with Disease Severity of Liver Cirrhosis.

Objective: The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1, FKN) has been implicated in modulating inflammatory and fibroproliferative diseases. The current study was performed to investigate the correlation of serum fractalkine levels with disease severity of liver fibrosis/cirrhosis (LC).

Methods: 162 LC patients and 140 healthy controls well enrolled in our study.

CircCCT3 Acts as a Sponge of miR-613 to Promote Tumor Growth of Pancreatic Cancer Through Regulating VEGFA/VEGFR2 Signaling.

Background: Circular RNAs (CircRNAs) have been recently implicated in the progression of pancreatic cancer (PC).

Aims: To investigate the involvement of CircCCT3 in PC and studying its interactions and functioning during the progression of PC in vitro and in vivo, using methods of molecular biology and bioinformatics.

Study Design: Experimental study.

Poly[[aqua-(μ(2)-oxalato)(μ(2)-2-oxido-pyridinium-3-carboxylato)dysprosium(III)] monohydrate].

In the title complex, {[Dy(C(6)H(4)NO(3))(C(2)O(4))(H(2)O)]·H(2)O}(n), the Dy(III) ion is coordinated by seven O atoms from two 2-oxidopyridinium-3-carboxylate ligands, two oxalate ligands and one water mol-ecule, displaying a distorted bicapped trigonal-prismatic geometry. The carboxyl-ate groups of the 2-oxidopyridinium-3-carboxylate and oxalate ligands link dysprosium metal centres, forming layers parallel to (100). These layers are further connected by inter-molecular O-H⋯O hydrogen-bonding inter-actions involving the coordin-ated water mol-ecules, forming a three-dimensional supra-molecular network.