Publications by authors named "Lian-Xing Liu"
Article Synopsis
- The study focuses on targeting tumor-specific antigens that are usually hidden within cells or secreted, using alpha-fetoprotein (AFP) in liver cancer as an example for CAR T-cell therapy.
- Researchers developed a human chimeric antigen receptor, AFP-CAR, which specifically recognizes the AFP peptide presented on tumor cells by the HLA-A*02:01 molecule.
- The results showed that AFP-CAR T cells effectively killed liver cancer cells while preserving healthy cells, demonstrating significant anti-tumor effects in various mouse models, indicating a promising strategy for liver cancer treatment.
Background: Developing an effective vaccine against human immunodeficiency virus type 1 (HIV-1) remains a grand challenge after more than two decades of intensive effort. It is partially due to the lack of suitable animal models for screening and prioritizing vaccine candidates. In this study, we aim to develop a mice model to test HIV-1 vaccine efficacy.
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- Recent studies suggest that co-infection with GB virus C (GBV-C) might slow down AIDS progression in HIV-1 patients, but other research has not confirmed this.
- Researchers conducted a study on 203 HIV-1 positive former blood donors in China, finding that 25.6% were co-infected with GBV-C.
- The study concluded that there was no significant link between GBV-C infection and CD4+ T cell counts or HIV viral loads, suggesting that GBV-C does not notably affect AIDS progression in late-stage chronic HIV-1 infection.
Objective: To explore the strategy to raise both mucosal and systemic anti-HIV-1 immunity.
Methods: Eighteen BALB/c rats were randomly divided into 2 groups, experimental group and control group. The experimental group were further subdivided into 4 subgroups of 3 mice: 3-dose HIV DNA vaccine group, 3-dose DNA vaccine + cholera toxin (CT) adjuvant subgroup, 1-dose recombinant Tiantan strain vaccinia-based vaccine subgroup, and 3-dose DNA vaccine + CT adjuvant + Tiantan strain vaccinia-based vaccine subgroup.