Publications by authors named "Lian-Jiao Zhou"
Cu-modified nanoparticles have been designed to mimic peroxidase, and their potent antibacterial and anti-biofilm abilities have been widely investigated. In this study, novel core-shell polydopamine (PDA)/Cu(OH)SO crystal (PDA/Cu) nanometer rods were prepared. The PDA/Cu nanometer rods show similar kinetic behaviors to chloride-activated peroxidases, exhibit excellent photothermal properties, and are sensitive to the concentrations of pH values and the substrate (i.
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- Nanomaterials like fluorescent gold nanoclusters (AuNCs) interact with biomolecules such as lysozyme (Lys), affecting their properties and functions.
- The study found that different surface ligands on AuNCs (dihydrolipoic acid and glutathione) quench Lys's fluorescence through distinct mechanisms, with DHLA-AuNCs significantly inhibiting Lys's enzymatic activity while GSH-AuNCs do not.
- The interactions occur primarily through electrostatic attractions and hydrophobic interactions, leading to notable structural changes in Lys when bound to DHLA-AuNCs, providing valuable insights for using nanomaterials in biological applications.
F16 is a mitochondria-targeted, broad-spectrum anticancer agent in the pre-clinic cancer therapy. Here we developed two fluorescent isomers of F16 (o-F16 and m-F16) with entirely different photophysical properties, uncoupling activity, and cytotoxicity by merely modifying the linking orientation of pyridinium and indole units. Individually, o-F16 acted as a strong uncoupler to reduce the mitochondrial respiration efficiency, while m-F16 could hardly uncouple the mitochondrial respiration due to its poor proton dissociation capability.
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