Effects of sulfasalazine on biopsy mucosal pathologies and histological grading of patients with active ulcerative colitis.

Aim: To investigate the mechanisms of sulfasalazine (SASP) in the treatment of ulcerative colitis (UC).

Methods: Changes of pathological signs and histological grading of 106 patients with active UC were observed before and after the treatment with SASP, 1 g, thrice daily for 6 wk.

Results: The effect of SASP on the vasculitis in lamina propria was 48.