Whole-genome resequencing reveals the uniqueness of Subei yak.

Subei yak is an essential local yak in the Gansu Province, which genetic resource has recently been discovered. It is a meat-milk dual-purpose variety with high fecundity and relatively stable population genetic structure. However, its population genetic structure and genetic diversity are yet to be reported.

A LC-MS-based serum pharmacochemistry approach to reveal the compatibility features of mutual promotion/assistance herb pairs in Xijiao Dihuang decoction.

Xijiao Dihuang decoction (XDT), a famous formula, was usually used to improve the prognosis of patients with blood-heat and blood-stasis syndrome-related diseases. There were some mutual promotion and mutual assistance herb pairs in XDT. However, the exact functions of these herb pairs in the compatibility of XDT were not elucidated due to the lack of appropriate methodologies.

Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.

Ethnopharmacological Relevance: Modified Simiaowan (MSM) is a six-herb formula that has been shown to be effective in gouty arthritis (GA) has been proven, but its regulatory mechanism has not been fully elucidated.

Aim Of The Study: To investigate the therapeutic effects and mechanism of MSM on gouty arthritis.

Materials And Methods: Mouse J774A.

Dual char-forming strategy driven MXene-based fire-proofing epoxy resin coupled with good toughness.

It is challenging that the functionalized MXene-based nanofillers are designed to modify the inherent flammability and poor toughness of epoxy polymeric materials and further to facilitate the application of EP composites. Herein, silicon-reinforced TiCT MXene-based nanoarchitectures (MXene@SiO) are synthesized by simple self-growth method, and its enhancement effects on epoxy resin (EP) are investigated. The as-prepared nanoarchitectures realize homogeneous dispersion in EP matrix, indicating well performance-enhancing potential.

Time-Dependent Effects of Physical Activity on Cardiovascular Risk Factors in Adults: A Systematic Review.

Purpose: Physical activity is an important non-drug-related method to prevent and treat cardiovascular diseases, but how exercise duration affects the cardiovascular metabolic risk factors in adults remains uncertain. This review systematically examines the time-dependent effects of physical activity on cardiovascular risk factors in adults and aims to further the understanding of the temporal therapeutics of exercise.

Methods: Following the PRISMA guidelines, the PubMed, Web of Science, EMBASE, and CNKI databases were systematically searched for relevant scientific studies from January 2000 to June 2022.

A Study on the Relationship Between Adolescent Health Behavior, BMI, and Blood Physical and Chemical Properties.

In this study, the blood test index, demographic data, and health promotion behavior of adolescents were analyzed to provide a reference for early prevention and treatment of physical decline and abnormal biochemical indexes of adolescents. Using a cross-sectional study design, 1,436 valid samples were obtained by stratified random sampling, and the data were processed by SPSS21.0 statistical analysis software.

The Survey on Adolescents' Cognition, Attitude, and Behavior of Using Analgesics: Take Sichuan and Chongqing as an Example.

Objectives: To explore the current situation of knowledge, attitude, and behavior about the correct use of analgesics among adolescents in Western Sichuan and Chongqing and its related factors and to provide a reference for health promotion schools to promote correct medication education and relevant policy-making.

Methods: A questionnaire survey was conducted among senior high school students in Sichuan and Chongqing by stratified random sampling. A total of 48 classes were surveyed and 2,280 valid questionnaires were obtained.

Serum Pharmacochemistry Combining Network Pharmacology to Discover the Active Constituents and Effect of Xijiao Dihuang Tang Prescription for Treatment of Blood-Heat and Blood-Stasis Syndrome-Related Disease.

Xijiao Dihuang Tang (XDT), a classic TCM prescription, has been used to clinically treat blood-heat and blood-stasis syndrome- (BHSS-) related diseases, including hemorrhagic stroke and sepsis. However, the active constituents and mechanism of XDT in the treatment of BHSS-related diseases have not been elucidated due to the lack of appropriate methodologies. In this study, serum pharmacochemistry and network pharmacology were used to explore the active constituents and the mechanism of XDT in the treatment of BHSS-related diseases.

The Influence of Family Sports Attitude on Children's Sports Participation, Screen Time, and Body Mass Index.

Children's physical health is an important resource for a country's future construction. However, researchers found that the physical fitness of young children around the world has declined during the two decades, from 1992 to 2012. The decline in the physique of young children has caused widespread concern around the world.

Flame-retardant activity of ternary integrated modified boron nitride nanosheets to epoxy resin.

In order to improve the fire safety of epoxy resin, ZIF-8 nanoparticle in-situ decorated boron nitride nanosheet (BN-OH/ZIF-8) is fabricated via self-assembly method and then ternary integrated BN-OH/ZIF-8/PA hybrids are prepared through the chemical etching effect of phytic acid. FTIR, XRD, XPS, TEM and TGA measurements are used to characterize the structure and morphology of the nanohybrids. The researches show that BN-OH/ZIF-8/PA not only uniformly distributed in EP matrix, but also improve the thermal stability of EP.

AgZDS, a gene encoding ζ-carotene desaturase, increases lutein and β-carotene contents in transgenic Arabidopsis and celery.

ζ-Carotene desaturase (ZDS) is one of the key enzymes regulating carotenoids biosynthesis and accumulation. Celery transgenic efficiency is low and it is difficult to obtain transgenic plants. The study on ZDS was limited in celery.

Comparison of Methods for the Estimation of the Maximum Oxygen Uptake of Men Drug Addicts.

Maximum oxygen uptake (VO) is an important respiratory physiological index of the aerobic endurance of the body, especially for special groups such as drug addicts, and it is an important indicator for assessing the cardiopulmonary function and formulating exercise prescriptions. Although the cardiopulmonary exercise test (CPX) is a classic method to directly measure VO, this method is limited by factors such as cumbersome operating procedures and expensive equipment, resulting in its relatively low applicability. Recently, many studies have begun to focus on the estimation of VO in different groups of people, but few studies have focused on drug addicts.

Modified Simiaowan prevents articular cartilage injury in experimental gouty arthritis by negative regulation of STAT3 pathway.

Ethnopharmacological Relevance: Modified Simiaowan (MSW) is a traditional Chinese medicine formula that is composed of six herbs. It has been widely used in the treatment of gouty arthritis.

Aim Of The Study: This study was designed to investigate the effect of MSW on gouty arthritis and explore the possible mechanisms.

The gene encoding lycopene epsilon cyclase of celery enhanced lutein and β-carotene contents and confers increased salt tolerance in Arabidopsis.

Celery (Apium graveolens L.) is a leafy vegetable of Apiaceae, which is greatly popular because of its rich nutrients. Lutein and β-carotene are two important carotenoids.

A celery transcriptional repressor AgERF8 negatively modulates abscisic acid and salt tolerance.

Ethylene response factors (ERFs) widely exist in plants and have been reported to be an important regulator of plant abiotic stress. Celery, a common economic vegetable of Apiaceae, contains lots of ERF transcription factors (TFs) with various functions. AP2/ERF TFs play positive or negative roles in plant growth and stress response.

Differential mRNA expression combined with network pharmacology reveals network effects of Liangxue Tongyu Prescription for acute intracerebral hemorrhagic rats.

Ethnopharmacological Relevance: Liangxue Tongyu Prescription (LTP) is a traditional Chinese medicine formula composed of 8 crude drugs that is widely used to treat acute intracerebral hemorrhage (AICH).

Aim Of The Study: To verify the efficacy of LTP on the survival time in the treatment of acute intracerebral hemorrhagic rats (AICHs), and to elucidate its network pharmacodynamic mechanism of multi-component, multi-target, and multi-signaling pathways.

Materials And Methods: Survival analysis was used to evaluate the survival time of AICH rats induced by different doses of collagenase and the efficacy of three doses of LTP in the treatment of AICH rats.

Study on the icosahedral fullerene structure with ultra-light and pressure resistance character.

An ultra-light icosahedral fullerene structure is described having 12 pentagonal faces at the vertices of the regular icosahedron and 20 triangular faces, which are expanded by hexagonal faces that consist of carbon atoms. When its size exceeds a critical value, the density of the icosahedron becomes lower than that of air. Since the hollow structure deforms under atmospheric pressure, we proposed the addition of helium atoms as a means to obtaining a floatable icosahedral fullerene with pressure-resistant character.

A novel phosphorus-containing MoS hybrid: Towards improving the fire safety of epoxy resin.

Layered molybdenum disulfide (MoS) has received significant attention due to various applications, such as catalysis, supercapacitors, batteries, and polymer nanocomposites. However, developing highly effective MoS-based polymer nanocomposites with superior dispersion resulting in improved thermal and flame retardant properties still remains a huge challenge. Herein, a kind of MoS hybrid was synthesized by the reaction of exfoliated MoS nanosheets with (4-carboxybutyl) triphenylphosphoniumbromide (TPP) via a cost-effective method, where TPP serves as a synergistic agent to further improve the dispersion and flame retardant efficiency of MoS.

Differential effects of genistein and 8-prenylgenistein on reproductive tissues in immature female mice.

Context: We identified an active prenylated derivative of genistein, 8-prenylgenistein (8PG) from Erythrina variegata L. (Leguminosae) and found that 8PG increased osteoprotective effects of genistein in oestrogen-deficient mice.

Objective: This study investigated and compared the oestrogenic effects of genistein and 8PG on uterus and vagina of immature mice.

Protective Effects of Ligustroflavone, an Active Compound from Ligustrum lucidum, on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist.

Ligustroflavone is one major compound contained in active fraction from Fructus Ligustri Lucidi (the fruit of Ligustrum lucidum), which could regulate parathyroid hormone (PTH) levels and improve calcium balance by acting on calcium-sensing receptors (CaSR). This study aimed to explore the potency of ligustroflavone as a CaSR antagonist and its protective effects against diabetic osteoporosis in mice. LF interacted well with the allosteric site of CaSR shown by molecular docking analysis, increased PTH release of primary parathyroid gland cells and suppressed extracellular calcium influx in HEK-293 cells.

Assessing the Pharmacological and Therapeutic Efficacy of Traditional Chinese Medicine Liangxue Tongyu Prescription for Intracerebral Hemorrhagic Stroke in Neurological Disease Models.

Intracerebral hemorrhage is a fatal subtype of stroke, with crucial impact on public health. Surgical removal of the hematoma as an early-stage treatment for ICH can't improve long-term prognosis remarkably. Liangxue tongyu prescription (LP), a Traditional Chinese Medicine (TCM) formula, includes eight ingredients and has been used to treat ICH in the clinical.

Therapeutic Effects of Kuan and Its Active Fraction on Acute Blood Stasis Rat Model and Identification Constituents by HPLC-QTOF/MS/MS.

Background: Kuan is widely used in the clinics for the treatment of blood stasis in China.

Objective: To evaluate the improving blood rheology and anti-inflammatory properties of Kuan extract (CO) and its active fraction (ACO) on acute blood stasis model Wistar rats and characterize the correlative constituents.

Materials And Methods: CO at 0.

Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.

MaiMenDong Decoction and WeiJing Decoction (Jin formula) is a traditional Chinese medication that consists of 8 medicinal plants, which recorded in the classical TCM literature and has been utilized in the treatment of lung diseases for hundreds of years in China. The present study aimed to determine the anti-tumor activity and the underlying mechanisms of Jin formula combined with cisplatin in the treatment of non-small cell lung cancer (NSCLC). Xenograft model of NCI-A549 was established in Balb/c nude mice.

Traditional Chinese Medicine Formula "Xiaofeng granules" suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate.

Ethnopharmacological Relevance: Xiaofeng Granules (XF) is a kind of granules prepared by the famous traditional Chinese medicine formula for its efficiency in treating gouty diseases.

Aim Of The Study: We investigated the relevance between XF that made from Modified simiaowan (MSW) as the anti-gouty arthritis drugs and protective mechanisms for cartilage matrix in order to provide the evidence for new drug application.

Materials And Methods: In the present study, we evaluated the anti-gouty arthritis activity of XF in rats and rabbits models induced by MSU together with chondrocytes focusing on the link to proteoglycan degradation in vitro studies.