Engineering vascularised organoid-on-a-chip: strategies, advances and future perspectives.

In recent years, advances in microfabrication technology and tissue engineering have propelled the development of a novel drug screening and disease modelling platform known as organoid-on-a-chip. This platform integrates organoids and organ-on-a-chip technologies, emerging as a promising approach for in vitro modelling of human organ physiology. Organoid-on-a-chip devices leverage microfluidic systems to simulate the physiological microenvironment of specific organs, offering a more dynamic and flexible setting that can mimic a more comprehensive human biological context.

Multifunctional cardiac microphysiological system based on transparent ITO electrodes for simultaneous optical measurement and electrical signal monitoring.

Drug-induced cardiotoxicity is a significant contributor to drug recalls, primarily attributed to limitations in existing drug screening platforms. Traditional heart-on-a-chip platforms often employ metallic electrodes to record cardiomyocyte electrical signals. However, this approach hinders direct cardiomyocyte morphology observation and typically yields limited functionality.

Multi-level magnetic microrobot delivery strategy within a hierarchical vascularized organ-on-a-chip.

Targeted microrobotic delivery within the circulatory system holds significant potential for medical theranostic applications. Existing delivery strategies of microrobots encounter challenges such as slow speed, limited navigation control, and dispersal under dynamic flow conditions. Furthermore, within the realm of microrobots, testing platforms often lack essential biological microenvironments, while studies conducted on animal models are constrained by limited detection resolution.

Organoid-on-a-chip: Current challenges, trends, and future scope toward medicine.

organoid models, typically defined as 3D multicellular aggregates, have been extensively used as a promising tool in drug screening, disease progression research, and precision medicine. Combined with advanced microfluidics technique, organoid-on-a-chip can flexibly replicate organs within the biomimetic physiological microenvironment by accurately regulating different parameters, such as fluid conditions and concentration gradients of biochemical factors. Since engineered organ reconstruction has opened a new paradigm in biomedicine, innovative approaches are increasingly required in micro-nano fabrication, tissue construction, and development of pharmaceutical products.

Time restricted feeding is associated with poor performance in specific cognitive domains of Suburb-Dwelling older Chinese.

The purpose of this study was to investigate the association between time restricted feeding (TRF) and different areas of cognitive function in the elderly in Chinese communities. This study consisted of 1353 community-dwelling Chinese older adults aged 60 years and older in Chongming area, Shanghai (563 males; the mean age, 73.38 ± 6.

Gender-specific prevalence and risk factors of mild cognitive impairment among older adults in Chongming, Shanghai, China.

Objective: This study explores the gender differences in the prevalence of mild cognitive impairment (MCI) and the correlation between multiple influencing factors.

Materials And Methods: The sample was comprised of 1325 relatively healthy participants aged ≥ 60 years in a Shanghai community-dwelling (557 males and 768 females). Cognitive function was assessed by Mini-Mental State Examination (MMSE).

Correction: Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip.

Correction for 'Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip' by Qinyu Li , , 2022, https://doi.org/10.1039/d1lc00767j.

Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip.

Reconstruction of 3D vascularized microtissues within microfabricated devices has rapidly developed in biomedical engineering, which can better mimic the tissue microphysiological function and accurately model human diseases . However, the traditional PDMS-based microfluidic devices suffer from the microfabrication with complex processes and usage limitations of either material properties or microstructure design, which drive the demand for easy processing and more accessible devices with a user-friendly interface. Here, we present an open microfluidic device through a rapid prototyping method by laser cutting in a cost-effective manner with high flexibility and compatibility.

[A practical system for B-mode ultrasound image acquisition and patient's medical history management].

A practical system of B-ultrasonic is here introduced. By a special medical video card, the video image is digitized and captured dynamically or statically into computer. This system realizes a variety of functions such as the B-ultrasonic video image's acquisition and display, as well as the editing, processing, managing, storage, printing, It can build the database of patient's case history automatically.