Publications by authors named "Liam Wetzel"
Article Synopsis
- CHCHD10 is a mitochondrial protein linked to familial and sporadic ALS-FTD, with mutations leading to decreased levels of the protein in affected brains.
- Mutations such as R15L and S59L disrupt mitophagy flux and inhibit the recruitment of Parkin, while the wild-type version of CHCHD10 enhances these processes.
- The study reveals that CHCHD10 regulates PINK1 levels by affecting PARL activity, linking impaired mitophagy to TDP-43 aggregation, a hallmark of FTD pathology.
