Publications by authors named "Liam Powles"
Article Synopsis
- Vaccines for blood-stage malaria focus on creating antibodies and T cell responses to prevent parasites from entering red blood cells, utilizing either Th1 or Th2 immune pathways.
- Recent research indicates that biodegradable pullulan-coated iron oxide nanoparticles (pIONPs) can be effectively used as carriers for malaria antigens, being non-toxic and without pro-inflammatory effects.
- The study demonstrated that when the blood-stage antigen MSP4/5 is attached to pIONPs, it successfully triggers both antibody production and T cell responses in mice, indicating pIONPs could be promising for future malaria vaccine developments.
Malaria vaccine research has been ongoing since the 1980s with limited success. However, recent improvements in our understanding of the immune responses required to combat each stage of infection will allow for intelligent design of both antigens and their associated delivery vaccine vehicles/vectors. Synthetic carriers (also known as vectors) are usually particulate and have multiple properties, which can be varied to control how an associated vaccine interacts with the host, and consequently how the immune response develops.
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