Publications by authors named "Liam Magee"
IL10 trains macrophage profibrotic function after lung injury.
Am J Physiol Lung Cell Mol Physiol
March 2022
Cx3cr1+ monocyte-derived macrophages (moMacs) are recruited to tissues after injury and are known to have profibrotic effects, but the cell-cell interactions and specific pathways that regulate this polarization and function are incompletely understood. Here we investigate the role of moMac-derived in bleomycin-induced lung fibrosis in mice. Deletion of with decreased bleomycin-induced lung fibrosis.
View Article and Find Full Text PDFArticle Synopsis
- Lung fibrosis, which worsens with age, is linked to negative outcomes in lung injuries and infections, but its underlying causes are not fully understood.* -
- Analysis of lung samples from healthy donors using RNA sequencing shows that as people age, there is an increase in cellular aging and activation of pathways that promote fibrosis, along with a loss of lung epithelial cells.* -
- Structural imaging of older lungs indicates a rise in collagen density and a reduction in lung function, contributing to fibrosis and related issues in respiratory health as people get older.*