Publications by authors named "Liam Lawlor"
Article Synopsis
- The study investigated the effect of a selective HDAC2&3 inhibitor, MI192, on the epigenetic reprogramming of human adipose-derived stem cells (hADSCs) to enhance their potential for bone tissue engineering.
- Results showed that MI192 treatment improved osteogenic differentiation of hADSCs when used at an optimal concentration of 30 μM and a pre-treatment of 2 days, while reducing cell viability in a dose-dependent manner.
- The findings indicated that MI192 enhances the expression of osteogenic markers and allows for reversible cell cycle arrest, suggesting its potential use in promoting bone tissue regeneration.
The use of human dental pulp stromal cells (hDPSCs) has gained increasing attention as an alternative stem cell source for bone tissue engineering. The modification of the cells' epigenetics has been found to play an important role in regulating differentiation, with the inhibition of histone deacetylases 3 (HDAC3) being linked to increased osteogenic differentiation. This study aimed to induce epigenetic reprogramming using the HDAC2 and 3 selective inhibitor, MI192 to promote hDPSCs osteogenic capacity for bone regeneration.
View Article and Find Full Text PDFThere are large knowledge gaps regarding how to control stem cells growth and differentiation. The limitations of currently available technologies, such as growth factors and/or gene therapies has led to the search of alternatives. We explore here how a cell's epigenome influences determination of cell type, and potential applications in tissue engineering.
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