Publications by authors named "Liam John Drew"
Nat Neurosci
November 2015
Article Synopsis
- - SSRIs, like fluoxetine, help treat depression, but how they work in the brain isn't fully understood; adult hippocampal neurogenesis plays a role in their effects.
- - Researchers found that deleting the serotonin 1A receptor (5HT1AR) from mature dentate gyrus granule cells (DG GCs) block the behavioral and hormonal effects of fluoxetine, while young adult-born granule cells (abGCs) are not affected.
- - The study indicates that for an antidepressant response to occur, both mature DG GCs and young abGCs need to be active and engaged with 5HT1AR.
