Publications by authors named "Liam Guiney"
Background: Socioeconomic status (SES) is an important determinant of healthcare outcomes in many settings, but few studies have evaluated the impact of SES among patients with aortic stenosis (AS). We sought to explore the association between SES and clinical characteristics, care quality and outcomes among patients undergoing transcatheter aortic valve implantation (TAVI) for severe AS.
Methods: Consecutive patients undergoing TAVI for severe AS at three hospitals between August 2008 and February 2023 were prospectively enrolled in a multicentre registry.
Symptoms of anxiety and/or depression (SAD) commonly co-exist in severe aortic stenosis. In patients who underwent transcatheter aortic valve implantation (TAVI), these symptoms are associated with increased morbidity and mortality. Despite this, mental health remains under-researched in the TAVI literature.
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- The majority of cholesterol in the bloodstream is in an esterified form, primarily produced by cardioprotective high-density lipoproteins (HDLs).
- Cholesteryl ester transfer protein (CETP) plays a key role in transferring cholesteryl esters and triglycerides between different lipoproteins, leading to a net movement of cholesterol out of HDLs, which could affect cardiovascular risk.
- Efforts to inhibit CETP activity have led to the creation of various treatments like monoclonal antibodies and small molecule inhibitors, with ongoing research into their effectiveness in reducing cardiovascular disease through large-scale clinical trials.