Publications by authors named "Lia Ribustello"
Research Question: What are the incidence and patterns of meiotic trisomies and recombination separately and in relation to each other at the blastocyst stage via single nucleotide polymorphism genotyping combined with array comparative genomic hybridization.
Design: Single nucleotide polymorphism microarrays were carried out on a total of 1442 blastocyst stage embryos derived from 268 fertile couples undergoing preimplantation genetic diagnosis for the purposes of avoiding transmittance of known single gene disorders to their offspring; 24-chromosome aneuploidy screening via array comparative genomic hybridization was carried out in parallel.
Results: One hundred per cent of meiotic trisomies identified in these embryos were of maternal origin and their incidence increased significantly with advancing maternal age (P < 0.
Article Synopsis
- The study aims to estimate the out-of-pocket costs for couples undergoing IVF with preimplantation genetic testing for aneuploidy (PGT-A) in order to achieve varying likelihoods of obtaining a euploid blastocyst, depending on the patient's age and AMH levels.
- A cost analysis was conducted using historical IVF data, employing statistical methods to simulate costs and likelihoods, and the findings show significant variations in costs based on age and AMH levels, ranging from approximately $15,000 to over $450,000.
- The developed counseling tool offers personalized financial insights for patients, assisting them in understanding the potential costs associated with achieving different success rates in obtaining healthy embryos.